Results 41 to 50 of about 509,621 (191)
L. longipalpis Jak-STAT-related multiple alignment and phylogenetic trees
, 2021 L. longipalpis Jak-STAT-related multiple alignment files generated in MUSCLE multiple sequence alignment built in Geneious 7.1.9 software (Biomatters, New Zealand). Phylogenetic trees were created using MEGA-X software, with the Maximum Likelihood method
Bruno Tinoco-Nunes (11633425) +6 more
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JAK-STAT in lymphoproliferative disorders
Oncoscience, 2015 In the early 1990's several groups were searching for the molecular basis of the signal transduction triggered by the engagement of plasma membrane receptors. The laboratories of Darnell, Kerr and Stark were first to identify proteins, which acted as intermediaries in interferon (IFN) signaling, known as the signal transducer and activator of ...
Raul, Rabadan, Giorgio, Inghirami
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Suppression of Autoimmune Arthritis by Small Molecule Inhibitors of the JAK/STAT Pathway
Pharmaceuticals, 2010 A skewed ratio of pro-inflammatory to anti-inflammatory cytokines, elevated growth factor synthesis and T- and B-lymphocyte activation are 3 hallmarks of rheumatoid arthritis (RA) pathology.
Charles J. Malemud
doaj +1 more source
Quercetin as a JAK–STAT inhibitor: a potential role in solid tumors and neurodegenerative diseases
Cellular & Molecular Biology Letters, 2022 The Janus kinase–signal transducer and activator of transcription (JAK–STAT) pathway is involved in many immunological processes, including cell growth, proliferation, differentiation, apoptosis, and inflammatory responses.
Hamidreza Zalpoor +7 more
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Infection-induced IL-10 and JAK-STAT: A review of the molecular circuitry controlling immune hyperactivity in response to pathogenic microbes [PDF]
, 2012 Generation of effective immune responses against pathogenic microbes depends on a fine balance between pro- and antiinflammatory responses. Interleukin-10 (IL-10) is essential in regulating this balance and has garnered renewed interest recently as a
Ulett, Glen +11 more
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Role of the JAK/STAT Pathway in Cervical Cancer: Its Relationship with HPV E6/E7 Oncoproteins
Cells, 2020 The janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway is associated with the regulation of essential cellular mechanisms, such as proliferation, invasion, survival, inflammation, and immunity.
Adriana Gutiérrez-Hoya +1 more
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Frontiers in Pharmacology, 2022 JAK/STAT signaling pathway is one of the important regulatory signaling cascades for the myriad of cellular processes initiated by various types of ligands such as growth factors, hormones, and cytokines. The physiological processes regulated by JAK/STAT
Bilal Rah +15 more
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The JAK-STAT pathway at 20 [PDF]
JAK-STAT, 2012 On September 22–24, 2011 a group of over 150 scientists convened at the National Institutes of Health in Bethesda, Maryland to celebrate the 20th anniversary of the definitive molecular studies that revealed the JAK-STAT pathway. Organized chiefly by John O’Shea with a big assist from Richard Jove and minor assists from David Levy, myself and others,
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JAK-STAT Signaling in Autoimmunity and Cancer [PDF]
Sana Parveen,1,2 Mariyam Fatma,1,2 Snober Shabnam Mir,1,2 Said Dermime,3,4 Shahab Uddin1,5,6 1Department of Biosciences, Faculty of Science, Integral University, Lucknow, India; 2Molecular Cell Biology Laboratory, Integral Centre of Excellence for ...
Fatma M +4 more
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Biomolecules, 2023 Vascular calcification (VC) is an age-related complication characterised by calcium-phosphate deposition in the arterial wall driven by the osteogenic transformation of vascular smooth muscle cells (VSMCs).
Federica Macrì +9 more
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