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JAK-STAT Signalling Pathway in Cancer [PDF]
Cancers, 2020 n ...
Andrew J. Brooks, Tracy Putoczki
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Regulation of JAK/STAT Signalling by Endocytosis [PDF]
, 2018 The JAK/STAT pathway is a highly evolutionarily conserved signal transduction pathway, whose activation can lead to a broad range of cellular outcomes. The pathway is used repeatedly during multiple developmental stages and in adult tissue, and therefore
Moore, Rachel
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Frontiers in Immunology, 2017 Interferons (IFNs), which were discovered a half century ago, are a group of secreted proteins that play key roles in innate immunity against viral infection.
Yuchen Nan +3 more
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JAK-STAT, 2012 In this issue of JAK-STAT, we introduce a series of reviews overlooking the ever-expanding field of myocardial JAK-STAT signaling. The history of cardiac JAK-STAT research begins in the mid-nineties, when various groups began to focus their attention on how myocardial physiology was specifically regulated through JAK-STAT signaling.
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TheDrosophilaJAK-STAT pathway [PDF]
JAK-STAT, 2013 The conservation of signaling cascades between humans and Drosophila, over more than 500 million years of evolutionary time, means that the genetic tractability of the fly can be used to its full advantage to understand the functional requirements for JAK-STAT pathway signaling across species.
Zeidler, Martin P, Bausek, Nina
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The Ups and Downs of STAT Inhibition in Acute Myeloid Leukemia
Biomedicines, 2021 Aberrant Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling is implicated in the pathogenesis of acute myeloid leukemia (AML), a highly heterogeneous hematopoietic malignancy.
Bernhard Moser +3 more
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Cytokines Activate JAK–STAT Signaling Pathway in MG-63 Cells on Titanium and Zirconia [PDF]
, 2022 Although titanium has been traditionally used as the gold standard for dental implants, recent years have seen the widespread application of zirconia implants given their superiority with regards to reduced bacterial adhesion, inflammation and cellular ...
Khaled Mukaddam +21 more
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Jak-STAT signaling in liver disease and repair : a way of living [PDF]
, 2005 Signaling through the Jak-STAT pathway is initiated when an extracellular signaling protein binds to its corresponding transmembrane receptor. This leads to activation of the Jaks.
Stutvoet, Simone Tjitske Dorothea
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Jaks, Stats and the Immune System
Immunobiology, 1997 Changes in gene expression are necessary for an adaptive response of cells to immunological stimuli and thus for their proper function in the context of the immune system. Regulatory inputs usually originate from cell surface receptors and in many cases affect the transcription rates of specific genes by modulating the activity of transcription factors.
T, Decker, A, Meinke
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Hipk is required for JAK/STAT activity during development and tumorigenesis.
PLoS ONE, 2019 Drosophila has been instrumental as a model system in studying signal transduction and revealing molecular functions in development and human diseases. A point mutation in the Drosophila Janus kinase JAK (called hop) causes constitutive activation of the
Gritta Tettweiler +3 more
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