Results 11 to 20 of about 509,621 (191)
JAK-STAT and bone metabolism [PDF]
JAK-STAT, 2013 Emerging evidences suggest Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling pathway plays an important role in bone development and metabolism.
Li, Jiliang
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JAK-STAT pathway inhibitors in dermatology [PDF]
Anais Brasileiros de Dermatologia, 2023 The JAK-STAT signaling pathway mediates important cellular processes such as immune response, carcinogenesis, cell differentiation, division and death. Therefore, drugs that interfere with different JAK-STAT signaling patterns have potential indications ...
Hélio Amante Miot +5 more
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Evolution of the JAK-STAT pathway [PDF]
JAK-STAT, 2013 The JAK-STAT pathway represents a finely tuned orchestra capable of rapidly facilitating an exquisite symphony of responses from a complex array of extracellular signals.
Clifford Liongue (13064595) +1 more
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Parameter inference in mechanistic models of cellular regulation and signalling pathways using gradient matching [PDF]
, 2012 A challenging problem in systems biology is parameter inference in mechanistic models of signalling pathways. In the present article, we investigate an approach based on gradient matching and nonparametric Bayesian modelling with Gaussian processes.
Dondelinger, F. +7 more
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JAK/STAT signaling in hepatocellular carcinoma
Hepatic Oncology, 2020 Liver cancer is the second most lethal cancer in the world with limited treatment options. Hepatocellular carcinoma (HCC), which accounts for more than 80% of all liver cancers, has had increasing global incidence over the past few years.
Justin Jit Hin Tang +3 more
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JAK-STAT, 2013 The regulation of energy balance requires a complex system to homeostatically maintain the adult body at a precise set point. The central nervous system, particularly the hypothalamus, plays a key role in integrating a variety of signals that can relay information about the body's energy stores.
Ladyman, Sharon R., Grattan, David R.
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Jaks, STATs, Cytokines, and Sepsis [PDF]
Clinical and Vaccine Immunology, 2002 Sepsis remains a significant cause of morbidity and mortality in the intensive care unit (68), affecting more than 500,000 patients per year in the United States (39). The incidence is increasing despite the major advances in the development of antimicrobial agents and other supportive treatments (56).
Melanie J, Scott +2 more
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The role of janus kinases in the treatment of autoimmune skin diseases [PDF]
Farmacja Polska, 2021 The JAK / STAT signaling pathway is a pleiotropic signal transduction pathway for many biochemical substances that are ligands, for example cytokines, growth factor, leptin, erythropoietin or interferons.
Arnold Kukowka +3 more
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Frontiers in Cell and Developmental Biology, 2022 The JAK-STAT pathway is evolutionary conserved. The simplicity of this signaling in Drosophila, due to the limited redundancy between pathway components, makes it an ideal model for investigation.
Charlotte Mallart +7 more
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JAK-STAT in Early Hematopoiesis and Leukemia
Frontiers in Cell and Developmental Biology, 2021 Hematopoietic stem cells (HSCs) produce all the terminally differentiated blood cells and are controlled by extracellular signals from the microenvironment, the bone marrow (BM) niche, as well as intrinsic cell signals.
Eirini Sofia Fasouli, Eleni Katsantoni
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