Results 1 to 10 of about 509,621 (191)
The Role of JAK/STAT Pathway in Fibrotic Diseases: Molecular and Cellular Mechanisms
Biomolecules, 2023 There are four members of the JAK family and seven of the STAT family in mammals. The JAK/STAT molecular pathway could be activated by broad hormones, cytokines, growth factors, and more.
Fengming Luo, Jia Liu, Faping Wang
exaly +3 more sources
JAK/STAT pathway: Extracellular signals, diseases, immunity, and therapeutic regimens
Frontiers in Bioengineering and Biotechnology, 2023 Janus kinase/signal transduction and transcription activation (JAK/STAT) pathways were originally thought to be intracellular signaling pathways that mediate cytokine signals in mammals.
Leiyun Wang
exaly +3 more sources
The JAK/STAT signaling pathway: from bench to clinic
Signal Transduction and Targeted Therapy, 2021 The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular processes, the JAK/STAT pathway constitutes a rapid membrane-to-nucleus ...
Xia Zhao, Xiaoyi Hu
exaly +2 more sources
JAK-STAT signaling pathway in cancer: from molecular mechanisms to clinical intervention. [PDF]
Mol CancerThe Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway is a conserved signaling network that mediates communication between extracellular cytokine stimulation and nuclear transcriptional responses.
Zhang X +8 more
europepmc +2 more sources
The Evolution of IL6-IL6R-JAK-STAT Signaling Pathway in Metazoan. [PDF]
Biology (Basel)Background: The Interleukin-6 (IL6)–Interleukin-6 receptor (IL6R)–Janus kinase (JAK)–signal transducer and activator of transcription (STAT) signaling pathway plays a crucial role in innate immunity by inducing the production of various immune effectors.
Yu H +5 more
europepmc +2 more sources
Disease Models & Mechanisms, 2022 Development involves tightly paced, reproducible sequences of events, yet it must adjust to conditions external to it, such as resource availability and organismal damage.
Xueya Cao +2 more
doaj +1 more source
Frontiers in Immunology, 2021 JAK/STAT signaling regulates central biological functions such as development, cell differentiation and immune responses. In Drosophila, misregulated JAK/STAT signaling in blood cells (hemocytes) induces their aberrant activation. Using mass spectrometry
Mirva Järvelä-Stölting +8 more
doaj +1 more source
Evolving cognition of the JAK-STAT signaling pathway: autoimmune disorders and cancer
Signal Transduction and Targeted Therapy, 2023 The Janus kinase (JAK) signal transducer and activator of transcription (JAK-STAT) pathway is an evolutionarily conserved mechanism of transmembrane signal transduction that enables cells to communicate with the exterior environment.
Chen Xue +8 more
doaj +1 more source
Targeting the immune microenvironment during immunotherapy for solid tumors
Molecular & Cellular Oncology, 2021 JAK/STAT signaling is a central hub in cancer development, progression, immunosurveillance and response to immunotherapy. We discuss recent advances in the role of the JAK/STAT pathway in immunotherapies.
Aiman Sabaawy, Saman Zeeshan
doaj +1 more source
Molecular dissection of Janus kinases as drug targets for inflammatory diseases
Frontiers in Immunology, 2022 The Janus kinase (JAK) family enzymes are non-receptor tyrosine kinases that phosphorylate cytokine receptors and signal transducer and activator of transcription (STAT) proteins in the JAK-STAT signaling pathway.
Sunghark Kwon
doaj +1 more source