Results 21 to 30 of about 509,621 (191)

Interferon functional analog activates antiviral Jak/Stat signaling through integrin in an arthropod

Cell Reports, 2021
Summary: Drosophila Vago is a small antiviral peptide. Its ortholog in Culex mosquito was found to be an interferon-like cytokine that limits virus replication through activating Jak/Stat signaling.
Jie Gao, Bao-Rui Zhao, Hui Zhang, Yan-Lin You, Fang Li, Xian-Wei Wang   +5 more
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Windpipe controls Drosophila intestinal homeostasis by regulating JAK/STAT pathway via promoting receptor endocytosis and lysosomal degradation. [PDF]

PLoS Genetics, 2015
The adult intestinal homeostasis is tightly controlled by proper proliferation and differentiation of intestinal stem cells. The JAK/STAT (Janus Kinase/Signal Transducer and Activator of Transcription) signaling pathway is essential for the regulation of
Wenyan Ren, Yan Zhang, Min Li, Longfei Wu, Guolun Wang, Gyeong-Hun Baeg, Jia You, Zhouhua Li, Xinhua Lin   +8 more
doaj   +1 more source

The JAK/STAT Pathway [PDF]

Cold Spring Harbor Perspectives in Biology, 2012
The Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling pathway mediates cellular responses to cytokines (e.g., IL-6) and growth factors (e.g., EGF).
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An immunoevasive strategy through clinically-relevant pan-cancer genomic and transcriptomic alterations of JAK-STAT signaling components

Molecular Medicine, 2019
Background Since its discovery almost three decades ago, the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway has paved the road for understanding inflammatory and immunity processes related to a wide range of human ...
Wai Hoong Chang, Alvina G. Lai
doaj   +1 more source

The JAK/STAT signaling pathway [PDF]

Journal of Cell Science, 2004
The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies.
Jason S, Rawlings, Kristin M, Rosler, Douglas A, Harrison   +2 more
openaire   +2 more sources

Modulation of human JAK-STAT pathway signaling by functionally conserved regulators [PDF]

, 2014
Both the core JAK-STAT pathway components and their in vivo roles have been widely conserved between vertebrates and invertebrate models such as Drosophila melanogaster.
Müller, Patrick, Zeidler, Martin P., Pugazhendhi, Dhamayanthi   +2 more
core   +1 more source

JAK and STAT gene mutations and JAK-STAT pathway activation in lympho- and myeloproliferative neoplasms [PDF]

, 2022
Lympho- and myeloproliferative neoplasms are a very heterogeneous group of haematological malignancies originating from a haematopoietic stem cell (HSC).
Andrzejewska, Dominika; Department of Hematology and Bone Mar row Transplantation, Medical Faculty, Poznan University of Medical Sciences, Poznan, Poland, Gulaczyk, Hanna; Department of Hematology and Bone Mar row Transplantation, Medical Faculty, Poznan University of Medical Sciences, Poznan, Poland, Kuczyńska, Martyna; Department of Hematology and Bone Mar row Transplantation, Medical Faculty, Poznan University of Medical Sciences, Poznan, Poland, Łączak, Michał; Department of Hematology and Bone Mar row Transplantation, Medical Faculty, Poznan University of Medical Sciences, Poznan, Poland, Grochowska, Wiktoria; Department of Hematology and Bone Mar row Transplantation, Medical Faculty, Poznan University of Medical Sciences, Poznan, Poland, Grygier, Joanna; Department of Hematology and Bone Mar row Transplantation, Medical Faculty, Poznan University of Medical Sciences, Poznan, Poland, Lewandowski, Krzysztof; Department of Hematology and Bone Mar row Transplantation, Medical Faculty, Poznan University of Medical Sciences, Poznan, Poland   +6 more
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Peroxiredoxin 4 Interacts With Domeless and Participates in Antibacterial Immune Response Through the JAK/STAT Pathway

Frontiers in Immunology, 2022
The JAK/STAT pathway plays an important role in the development and immune responses of animals. In vertebrates, families of cytokines or growth factors act as activators of the JAK/STAT pathway; however, the activators for the JAK/STAT signaling pathway
Xiao-qin Ran, Lin Gao, Meng Yan, Cui-jie Kang   +3 more
doaj   +1 more source

Chikungunya virus nonstructural protein 2 inhibits type I/II interferon-stimulated JAK-STAT signaling [PDF]

, 2010
Chikungunya virus (CHIKV) is an emerging human pathogen transmitted by mosquitoes. Like that of other alphaviruses, CHIKV replication causes general host shutoff, leading to severe cytopathicity in mammalian cells, and inhibits the ability of infected ...
Ligtenberg, M., Suhrbier, A., Corinne Geertsema, Esther Schnettler, Fros, J., Just M. Vlak, Maarten Ligtenberg, Geertsema, C., Suhrbier, Andreas, Wen Jun Liu, Natalie A. Prow, Vlak, J.M., Dana L. Vanlandingham, Ligtenberg, Maarten, Khromykh, Alexander A., Jelke J. Fros, Vanlandingham, D.L., Vlak, Just M., Schnettler, E., Fros, J.J., Gorben P. Pijlman, Pijlman, G.P., Liu, W.J., Khromykh, A.A., Prow, A., Fros, Jelke J., Vanlandingham, Dana L., Liu, Wen Jun, Geertsema, Corinne, Prow, Natalie A., Alexander A. Khromykh, Schnettler, Esther, Pijlman, Gorben P., Andreas Suhrbier, Prow, N.A.   +34 more
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The JAK-STAT Pathway at Twenty [PDF]

Immunity, 2012
We look back on the discoveries that the tyrosine kinases TYK2 and JAK1 and the transcription factors STAT1, STAT2, and IRF9 are required for the cellular response to type I interferons. This initial description of the JAK-STAT pathway led quickly to additional discoveries that type II interferons and many other cytokines signal through similar ...
Stark, George R., Darnell, James E.
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