Results 61 to 70 of about 509,621 (191)
The JAK-STAT pathway promotes persistent viral infection by activating apoptosis in insect vectors.
PLoS Pathogens, 2023 The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway is an evolutionarily conserved signaling pathway that can regulate various biological processes.
Yan Zhang +9 more
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Cytokines and JAK–STAT Signaling
Experimental Cell Research, 1999 Characterization of the ability of IFNs to induce immediate early genes led to the identification of the STAT (signal transducers and activators of transcription) signaling paradigm. STATs are activated at the receptor and then directly transduce signals to the nucleus.
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PLoS ONE, 2014 Identifying agents that inhibit STAT-3, a cytosolic transcription factor involved in the activation of various genes implicated in tumour progression is a promising strategy for cancer chemoprevention.
J Kowshik +5 more
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The JAK/STAT Pathway in Skeletal Muscle Pathophysiology
Frontiers in Physiology, 2019 The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is a key intracellular mediator of a variety of metabolically relevant hormones and cytokines, including the interleukin-6 (IL-6) family of cytokines.
Viviana Moresi +5 more
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Signal transducer and activator of transcription-1 localizes to the mitochondria and modulates mitophagy [PDF]
, 2013 The signal transducer and activator of transcription (STAT) proteins are latent transcription factors that have been shown to be involved in cell proliferation, development, apoptosis, and autophagy. STAT proteins undergo activation by phosphorylation at
Stephanou, A. +4 more
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Cytokine & Growth Factor Reviews, 1997 An international workshop on "Cytokines, Signaling and the Jak/Stat Pathway' organized by Peter C. Heinrich of the Klinikum der RWTH Aachen under the auspices of DFG-Forschergruppe was held in Aachen, Germany, on 4-5 October 1996. In this review David Levy notes that even though some diagrams shown at the meeting displayed more arrows than there were ...
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Glycoprotein 130 Cytokine Signal as a Therapeutic Target Against Cardiovascular Diseases
Journal of Pharmacological Sciences, 2011 .: Postnatal cardiomyocytes have only limited capacity of proliferation. Therefore, the myocardium is intrinsically equipped with cardioprotective machineries and protects itself from pathological stresses.
Yasushi Fujio +8 more
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JAK-STAT pathway-associated transcripts differentially expressed in Cstb-/- microglia.
, 2016 JAK-STAT pathway-associated transcripts differentially expressed in Cstb-/- microglia.
Kaarel Krjutškov (3161472) +7 more
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JAK/STAT signaling in hematological malignancies [PDF]
Oncogene, 2012 The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is central to signaling by cytokine receptors, a superfamily of more than 30 transmembrane proteins that recognize specific cytokines, and is critical in blood formation and immune response.
W, Vainchenker, S N, Constantinescu
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1H NMR Study on Serum Metabonomic Alterations Induced by JAK/STAT Pathway Inhibitor in C57BL/6 Mice
Chinese Journal of Magnetic Resonance, 2018 JAK/STAT pathway inhibitor has been used in clinic trial for several diseases. However, the adverse effect of systematic administration of JAK/STAT pathway inhibitors on cellular function is largely unknown.
ZHAO Xin +3 more
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