Results 191 to 200 of about 94,897 (251)

Lost and found in translation: the value of the human imiquimod model

British Journal of Clinical Pharmacology, EarlyView.
Topical imiquimod (IMQ), a Toll‐like receptor (TLR) 7 agonist, induces transient cutaneous inflammation and is widely used in preclinical research as a ‘psoriasis‐like’ mouse model. However, accumulating evidence indicates substantial divergence between IMQ‐driven biology and human plaque psoriasis pathogenesis.
Anouk C. Meijs, Juliette A. van den Noort, Salma Assil, Naomi B. Klarenbeek, Matthijs Moerland, Tessa Niemeyer‐van der Kolk, Robert Rissmann   +6 more
wiley   +1 more source

Correction: Billah et al. Remote Ischemic Preconditioning Induces Cardioprotective Autophagy and Signals Through the IL-6-Dependent JAK-STAT Pathway. <i>Int. J. Mol. Sci.</i> 2020, <i>21</i>, 1692. [PDF]

Int J Mol Sci
Billah M, Ridiandries A, Allahwala UK, Mudaliar H, Dona A, Hunyor S, Khachigian LM, Bhindi R.   +7 more
europepmc   +1 more source

Relationships among nitrous oxide exposure, neurological injury and biomarkers

British Journal of Clinical Pharmacology, EarlyView.
Aims Recreational nitrous oxide (N2O) misuse is an increasing public health problem associated with functional cobalamin (B12) deficiency and severe neurological complications. Despite growing recognition of its harms, the dose–response relationship and clinical value of biomarkers remain unclear.
Laxna Bhujel, Angela L. Chiew, Bhashita Jagarlamudi, Pramod Chandru, Naren Gunja, Nancy Briggs, Betty S. Chan   +6 more
wiley   +1 more source

JAK-STAT pathway inhibition modulates centrally sensitised default mode network hubs in rheumatoid arthritis pain

Stefanov K, Parkinson JT, Sunzini F, Al-Wasity S, Kaplan CM, Schrepf A, Ichesco E, Porter DA, Keith GA, McGucken A, Brock J, Aldehmi N, Paramo-Fiscal L, Tulunay-Virlan A, Arnott M, Lau T, Goodyear C, Thut G, Shenker N, McInnes IB, Clauw DJ, Cavangh J, Basu N.   +22 more
europepmc   +1 more source

MERS-CoV and SARS-CoV-1 proteins inhibit the IFN-α JAK/STAT pathway of epithelial cells, via IFN-λ-induced USP18. [PDF]

Front Immunol
Zhang Y, Stevenson NJ.
europepmc   +1 more source

Impact of Agitation Power Input on Aspergillus oryzae Metabolism: Application of Multi‐Omics on an Industrial Enzyme Fermentation

Biotechnology and Bioengineering, EarlyView.
ABSTRACT The agitation power input substantially impacts the oxygen transfer rate in aerobic fermentation processes. Furthermore, in a carbon‐limited process where the substrate feed rate is controlled by the concentration of dissolved oxygen, the power input will consequently govern the feed rate.
Mariana Albino, Jean‐Marie Mouillon, Gisela Nadal‐Rey, Carina L. Gargalo, Ulrich Krühne, Krist V. Gernaey, Mads O. Albæk   +6 more
wiley   +1 more source

Biomaterials for modulating cellular responses of endogenous tendon stem/progenitor cells: A promising avenue for tendon regeneration

BMEMat, EarlyView.
This review comprehensively summarizes emerging biomaterial‐based strategies and underlying mechanisms for modulating endogenous tendon stem/progenitor cells (TSPCs). It offers the most recent insights into TSPC physiology and potential applications of tissue engineering and regenerative medicine in tendons.
Zeyu Zhu, Renwang Sheng, Mumin Cao, Ludvig J. Backman, Yucheng Gao, Hao Wang, Cheng Zhang, Jialin Chen, Wei Zhang, Yunfeng Rui   +9 more
wiley   +1 more source

Pseudorabies Virus UL41 Hijacks IFN Response via JAK/STAT Pathway While Cellular TRIM21 Blocks it Through K48 Ubiquitination. [PDF]

Transbound Emerg Dis
Li X, Zheng J, Zhang G, Li P, Dong M, Liu Q, Ren L.   +6 more
europepmc   +1 more source

A biomechanical optimized Zr58Cu25Al14Nb3 bulk metallic glass dental implant improves peri‐implant stress distribution and bone quality under physiological loading

BMEMat, EarlyView.
This study reports a novel Zr58Cu25Al14Nb3 bulk metallic glass that possesses high mechanical strength and low elastic modulus, which further promotes efficient mechanotransduction and significantly improves peri‐implant bone quality upon cyclic occlusal loading.
Yunshu Wu, Feifei Wang, Yuan He, Yaopeng Zhang, Yuhao Zeng, Fu Zheng, Zhanqi Wei, Sukun Tian, Kinon Chen, Baoan Sun, Yuchun Sun   +10 more
wiley   +1 more source

IFN-γ increases δ-globin gene expression through activation of the JAK/STAT pathway in erythroid cells.

Blood
Zhu J, Chin K, Zou J, Aerbajinai W, Lin WC, Li H, Rodgers GP.   +6 more
europepmc   +1 more source