The JAK/STAT signaling pathway: from bench to clinic [PDF]
Signal Transduction and Targeted Therapy, 2021 The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular processes, the JAK/STAT pathway constitutes a rapid membrane-to-nucleus ...
Xiaoyi Hu +4 more
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Evolving cognition of the JAK-STAT signaling pathway: autoimmune disorders and cancer
Signal Transduction and Targeted Therapy, 2023 The Janus kinase (JAK) signal transducer and activator of transcription (JAK-STAT) pathway is an evolutionarily conserved mechanism of transmembrane signal transduction that enables cells to communicate with the exterior environment.
Chen Xue +8 more
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Pharmacological Effects of Polyphenol Phytochemicals on the JAK-STAT Signaling Pathway [PDF]
Frontiers in Pharmacology, 2021 The JAK-STAT signaling pathway is a common pathway of many cytokine signal transductions, closely related to cell proliferation, apoptosis, differentiation, and inflammatory response.
Qianqian Yin +6 more
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JAK-STAT signaling pathway in cancer: from molecular mechanisms to clinical intervention [PDF]
Molecular CancerThe Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway is a conserved signaling network that mediates communication between extracellular cytokine stimulation and nuclear transcriptional responses.
Xiaoqian Zhang +8 more
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SLC15A4 promotes oral cancer progression by regulating TLR9 and activating the JAK/STAT signaling pathway [PDF]
Head & Face MedicineBackground Oral cancer continues to pose a major health problem worldwide, characterized by few treatment options and an unfavorable prognosis. The solute carrier family 15 member 4 (SLC15A4) has been reported to be associated with immune responses ...
Meiling Feng +4 more
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Plant Extracts Downregulating the JAK/STAT Signaling Pathway as a Potential Tool for Psoriasis Management: A Review [PDF]
PharmaceuticalsBackground/Objectives: Among the Inflammatory Skin Diseases (ISDs), psoriasis represents a recalcitrant and disabling dermatological disorder associated with perpetuated inflammatory conditions.
Maria Rosaria Perri +6 more
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The Role of JAK/STAT Pathway in Fibrotic Diseases: Molecular and Cellular Mechanisms
Biomolecules, 2023 There are four members of the JAK family and seven of the STAT family in mammals. The JAK/STAT molecular pathway could be activated by broad hormones, cytokines, growth factors, and more.
Jia Liu, Faping Wang, Fengming Luo
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Frontiers in Immunology, 2021 JAK/STAT signaling regulates central biological functions such as development, cell differentiation and immune responses. In Drosophila, misregulated JAK/STAT signaling in blood cells (hemocytes) induces their aberrant activation. Using mass spectrometry
Mirva Järvelä-Stölting +8 more
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The role of janus kinases in the treatment of autoimmune skin diseases [PDF]
Farmacja Polska, 2021 The JAK / STAT signaling pathway is a pleiotropic signal transduction pathway for many biochemical substances that are ligands, for example cytokines, growth factor, leptin, erythropoietin or interferons.
Arnold Kukowka +3 more
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Latest Advances in the Role of JAK/STAT Signaling Pathway in Autoimmune Rheumatic Diseases [PDF]
Zhongguo quanke yixue, 2022 The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway is a ubiquitously expressed intracellular signal transduction pathway involved in cell proliferation, differentiation, apoptosis, immune regulation and other ...
Fanni XIAO, Yufeng QING, Quanbo ZHANG
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