Results 41 to 50 of about 2,163,748 (287)

An immunoevasive strategy through clinically-relevant pan-cancer genomic and transcriptomic alterations of JAK-STAT signaling components

Molecular Medicine, 2019
Background Since its discovery almost three decades ago, the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway has paved the road for understanding inflammatory and immunity processes related to a wide range of human ...
Wai Hoong Chang, Alvina G. Lai
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Impaired JAK-STAT pathway signaling in leukocytes of the frail elderly [PDF]

Immunity & Ageing, 2022
Abstract Background Elderly often show reduced immune functioning and can develop chronic low-grade inflammation. Why some elderly are more prone to become frail is unknown. We investigated whether frailty is associated with altered cytokine signaling through the JAK-STAT
Leonard Daniël Samson, Peter Engelfriet, W. M. Monique Verschuren, H. Susan J. Picavet, José A. Ferreira, Mary-lène de Zeeuw-Brouwer, Anne-Marie Buisman, A. Mieke H. Boots   +7 more
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Targeting the immune microenvironment during immunotherapy for solid tumors

Molecular & Cellular Oncology, 2021
JAK/STAT signaling is a central hub in cancer development, progression, immunosurveillance and response to immunotherapy. We discuss recent advances in the role of the JAK/STAT pathway in immunotherapies.
Aiman Sabaawy, Saman Zeeshan
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Increased STAT1 signaling in endocrine-resistant breast cancer [PDF]

, 2014
Funding: China Scholarship Council, University of Edinburgh, Scottish Funding Council and Breakthrough Breast Cancer.Proteomic profiling of the estrogen/tamoxifen-sensitive MCF-7 cell line and its partially sensitive (MCF-7/LCC1) and fully resistant (MCF-
Thomas Jeremy S., Faratian Dana, Huang Rui, Sims Andrew H., Dana Faratian (171110), Simon P. Langdon, Danielle Wilson (550968), David J. Harrison (171106), Jeremy S. Thomas, Dana Faratian, Rui Huang, Wilson Danielle, Harrison David J., David J. Harrison, Danielle Wilson, Simon P Langdon, Thomas, Jeremy S, Sims, Andrew H, Andrew H. Sims (108040), Harrison, David J, Rui Huang (141490), Huang, Rui, Simon P. Langdon (207293), Wilson, Danielle, David J Harrison, Thomas, Jeremy, Langdon Simon P., Faratian, Dana, Andrew H. Sims, Andrew H Sims, Jeremy S Thomas, Jeremy S. Thomas (550969), Langdon, Simon P   +32 more
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JAK-STAT Signaling in Autoimmunity and Cancer [PDF]

Sana Parveen,1,2 Mariyam Fatma,1,2 Snober Shabnam Mir,1,2 Said Dermime,3,4 Shahab Uddin1,5,6 1Department of Biosciences, Faculty of Science, Integral University, Lucknow, India; 2Molecular Cell Biology Laboratory, Integral Centre of Excellence for ...
Fatma M, Uddin S, Parveen S, Mir SS, Dermime S   +4 more
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Systematic Review: JAK-STAT Regulation and Its Impact on Inflammation Response in ARDS from COVID-19

Immuno
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has had a global impact and resulted in millions of deaths worldwide. The course of the Janus kinase signaling transducers and activators (JAK-STAT) pathway is an important molecular ...
Irasema Rodriguez, Kate J. F. Carnevale
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JAK-STAT and bone metabolism

, 2013
Emerging evidences suggest Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling pathway plays an important role in bone development and metabolism.
Li, Jiliang
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Cytokine-induced Src homology 2 protein (CIS) promotes T cell receptor-mediated proliferation and prolongs survival of activated T cells [PDF]

, 2000
Copyright @ 2000 The Rockefeller University Press. This article is shared under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/ and http://creativecommons ...
Sjögren, HO, Paulsson, KM, Anette Sundstedt, Xu, X., Chen, S, Xiufeng Xu, Chen, Shangwu, Sundstedt, Anette, Karlsson, Stefan, Hans-Olov Sjögren, Karlsson, S, Li, Suling, Paulsson, Kajsa, Wang, P, Kajsa M. Paulsson, Sjögren, Hans Olov, Suling Li, Sundstedt, A, Stefan Karlsson, Xu, X, Anderson, P, Ping Wang, Wang, Ping, Shangwu Chen, Per Anderson, andersson, Per, andersson, Per,, Karlsson, Stefan,, Chen, Shangwu,, Li, Suling,, Paulsson, Kajsa,, Xu, X.,, Sjögren, Hans Olov,, Wang, Ping,, Sundstedt, Anette,, Lund University.   +35 more
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JAK/STAT signaling in diabetic kidney disease

Frontiers in Cell and Developmental Biology, 2023
Diabetic kidney disease (DKD) is the most important microvascular complication of diabetes and the leading cause of end-stage renal disease (ESRD) worldwide.
Yingjun Liu, Wenkuan Wang, Jintao Zhang, Shuo Gao, Tingting Xu, Yonghui Yin   +5 more
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The JAK-STAT Signaling Pathway: Input and Output Integration [PDF]

The Journal of Immunology, 2007
Abstract Universal and essential to cytokine receptor signaling, the JAK-STAT pathway is one of the best understood signal transduction cascades. Almost 40 cytokine receptors signal through combinations of four JAK and seven STAT family members, suggesting commonality across the JAK-STAT signaling system.
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