Results 31 to 40 of about 2,163,748 (287)

Modulation of human JAK-STAT pathway signaling by functionally conserved regulators [PDF]

, 2014
Both the core JAK-STAT pathway components and their in vivo roles have been widely conserved between vertebrates and invertebrate models such as Drosophila melanogaster.
Müller, Patrick, Zeidler, Martin P., Pugazhendhi, Dhamayanthi   +2 more
core   +1 more source

Interferon signaling in chronic hepatitis C : mechanisms and implications for therapy [PDF]

, 2008
Hepatitis C virus (HCV) infection is a major cause of chronic liver disease worldwide and can lead to liver cirrhosis and hepatocellular carcinoma.
Sarasin-Filipowicz, Magdalena
core   +1 more source

Interferon functional analog activates antiviral Jak/Stat signaling through integrin in an arthropod

Cell Reports, 2021
Summary: Drosophila Vago is a small antiviral peptide. Its ortholog in Culex mosquito was found to be an interferon-like cytokine that limits virus replication through activating Jak/Stat signaling.
Jie Gao, Bao-Rui Zhao, Hui Zhang, Yan-Lin You, Fang Li, Xian-Wei Wang   +5 more
doaj   +1 more source

Chikungunya virus nonstructural protein 2 inhibits type I/II interferon-stimulated JAK-STAT signaling [PDF]

, 2010
Chikungunya virus (CHIKV) is an emerging human pathogen transmitted by mosquitoes. Like that of other alphaviruses, CHIKV replication causes general host shutoff, leading to severe cytopathicity in mammalian cells, and inhibits the ability of infected ...
Ligtenberg, M., Suhrbier, A., Corinne Geertsema, Esther Schnettler, Fros, J., Just M. Vlak, Maarten Ligtenberg, Geertsema, C., Suhrbier, Andreas, Wen Jun Liu, Natalie A. Prow, Vlak, J.M., Dana L. Vanlandingham, Ligtenberg, Maarten, Khromykh, Alexander A., Jelke J. Fros, Vanlandingham, D.L., Vlak, Just M., Schnettler, E., Fros, J.J., Gorben P. Pijlman, Pijlman, G.P., Liu, W.J., Khromykh, A.A., Prow, A., Fros, Jelke J., Vanlandingham, Dana L., Liu, Wen Jun, Geertsema, Corinne, Prow, Natalie A., Alexander A. Khromykh, Schnettler, Esther, Pijlman, Gorben P., Andreas Suhrbier, Prow, N.A.   +34 more
core   +1 more source

Jak-STAT signaling in liver disease and repair : a way of living [PDF]

, 2005
Signaling through the Jak-STAT pathway is initiated when an extracellular signaling protein binds to its corresponding transmembrane receptor. This leads to activation of the Jaks.
Stutvoet, Simone Tjitske Dorothea
core   +1 more source

The JAK-STAT pathway promotes persistent viral infection by activating apoptosis in insect vectors.

PLoS Pathogens, 2023
The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway is an evolutionarily conserved signaling pathway that can regulate various biological processes.
Yan Zhang, Bo-Xue Li, Qian-Zhuo Mao, Ji-Chong Zhuo, Hai-Jian Huang, Jia-Bao Lu, Chuan-Xi Zhang, Jun-Min Li, Jian-Ping Chen, Gang Lu   +9 more
doaj   +1 more source

Control mechanism of JAK/STAT signal transduction pathway [PDF]

FEBS Letters, 2002
Suppressor of cytokine signaling‐1 (SOCS1) was identified as the negative regulator of Janus kinase (JAK) and signal transducer and activator of transcription (STAT) signal transduction pathway. However, the kinetics and control mechanism of the pathway have not yet been fully understood.
Yamada, Satoshi, Shiono, Satoru, Joo, Akiko, Yoshimura, Akihiko   +3 more
openaire   +2 more sources

Interplay between Janus Kinase/Signal Transducer and Activator of Transcription Signaling Activated by Type I Interferons and Viral Antagonism

Frontiers in Immunology, 2017
Interferons (IFNs), which were discovered a half century ago, are a group of secreted proteins that play key roles in innate immunity against viral infection.
Yuchen Nan, Yuchen Nan, Chunyan Wu, Yan-Jin Zhang   +3 more
doaj   +1 more source

JAK/STAT Signaling: Molecular Targets, Therapeutic Opportunities, and Limitations of Targeted Inhibitions in Solid Malignancies

Frontiers in Pharmacology, 2022
JAK/STAT signaling pathway is one of the important regulatory signaling cascades for the myriad of cellular processes initiated by various types of ligands such as growth factors, hormones, and cytokines. The physiological processes regulated by JAK/STAT
Bilal Rah, Rafiq A Rather, Gh Rasool Bhat, Abdul Basit Baba, Ifra Mushtaq, Muzamil Farooq, Tahira Yousuf, Sadaf B Dar, Sabra Parveen, Rukhsana Hassan, Fozia Mohammad, Iqbal Qassim, Abida Bhat, Shazia Ali, Mahrukh Hamid Zargar, Dil Afroze   +15 more
doaj   +1 more source

Protein phosphatase 2A inhibits interferon signaling through the Jak STAT pathway and promotes hepatitis C viral replication [PDF]

, 2014
The first part of the work demonstrate the role of PP2A in IFN-α induced Jak-STAT1 signaling and HCV replication. We show here that PP2Ac activity is not required for IFN-α induced tyrosine phosphorylation of Jak1/Tyk2 and STAT1.
Shanker, Vijay
core   +1 more source