Results 21 to 30 of about 2,163,748 (287)
Cytokines Activate JAK–STAT Signaling Pathway in MG-63 Cells on Titanium and Zirconia [PDF]
, 2022 Although titanium has been traditionally used as the gold standard for dental implants, recent years have seen the widespread application of zirconia implants given their superiority with regards to reduced bacterial adhesion, inflammation and cellular ...
Khaled Mukaddam +21 more
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Windpipe controls Drosophila intestinal homeostasis by regulating JAK/STAT pathway via promoting receptor endocytosis and lysosomal degradation. [PDF]
PLoS Genetics, 2015 The adult intestinal homeostasis is tightly controlled by proper proliferation and differentiation of intestinal stem cells. The JAK/STAT (Janus Kinase/Signal Transducer and Activator of Transcription) signaling pathway is essential for the regulation of
Wenyan Ren +8 more
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Molecular dissection of Janus kinases as drug targets for inflammatory diseases
Frontiers in Immunology, 2022 The Janus kinase (JAK) family enzymes are non-receptor tyrosine kinases that phosphorylate cytokine receptors and signal transducer and activator of transcription (STAT) proteins in the JAK-STAT signaling pathway.
Sunghark Kwon
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Biology and significance of the JAK/STAT signalling pathways [PDF]
Growth Factors, 2012 Since its discovery two decades ago, the activation of the Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway by numerous cytokines and growth factors has resulted in it becoming one of the most well-studied intracellular signalling networks.
Hiu, Kiu, Sandra E, Nicholson
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Frontiers in Cell and Developmental Biology, 2022 The JAK-STAT pathway is evolutionary conserved. The simplicity of this signaling in Drosophila, due to the limited redundancy between pathway components, makes it an ideal model for investigation.
Charlotte Mallart +7 more
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Pharmaceutical intervention in the JAK/STAT signaling pathway [PDF]
Oncogene, 2000 Many cytokines exert their effect via the JAK/STAT signal transduction pathway. Due to the medical relevance of many of these cytokines, they are being exploited, either directly, or through antagonists, as therapeutics for a variety of serious diseases.
H M, Seidel, P, Lamb, J, Rosen
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SOCS regulation of the JAK/STAT signalling pathway [PDF]
Seminars in Cell & Developmental Biology, 2008 The suppressor of cytokine signalling (SOCS) proteins were, as their name suggests, first described as inhibitors of cytokine signalling. While their actions clearly now extend to other intracellular pathways, they remain key negative regulators of cytokine and growth factor signalling.
Ben A, Croker +2 more
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Frontiers in Cell and Developmental Biology, 2021 Diminished regeneration or healing capacity of tendon occurs during aging. It has been well demonstrated that tendon stem/progenitor cells (TSPCs) play a vital role in tendon maintenance and repair.
Minhao Chen +20 more
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miR-135a inhibits airway inflammatory response in asthmatic mice via regulating JAK/STAT signaling pathway [PDF]
Brazilian Journal of Medical and Biological Research, 2021 The objective of this study was to investigate the inhibitory effect of miR-135a in regulating JAK/STAT signaling pathway on airway inflammation in asthmatic mice. An asthma model was established by sensitization and stimulation with ovalbumin (OVA), and
Xue-peng Huang +2 more
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Protein ISGylation modulates the JAK-STAT signaling pathway [PDF]
Genes & Development, 2003 ISG15 is one of the most strongly induced genes upon viral infection, type I interferon (IFN) stimulation, and lipopolysaccharide (LPS) stimulation. Here we report that mice lacking UBP43, a protease that removes ISG15 from ISGylated proteins, are hypersensitive to type I IFN.
Oxana A, Malakhova +8 more
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