Research Advances of JAK/STAT Signaling Pathway in Lung Cancer
Chinese Journal of Lung Cancer, 2019 Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway is one of the downstream pathways of cytokine signaling transduction. It regulates cell development, differentiation, proliferation, apoptosis and so on.
Xin YANG, Zhe TANG, Peng ZHANG, Li ZHANG
doaj +4 more sources
Role of the JAK/STAT Pathway in Cervical Cancer: Its Relationship with HPV E6/E7 Oncoproteins
Cells, 2020 The janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway is associated with the regulation of essential cellular mechanisms, such as proliferation, invasion, survival, inflammation, and immunity.
Adriana Gutiérrez-Hoya +1 more
doaj +2 more sources
Targeting the JAK/STAT Signaling Pathway Using Phytocompounds for Cancer Prevention and Therapy
Cells, 2020 Cancer is a prevalent cause of mortality around the world. Aberrated activation of Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway promotes tumorigenesis.
Sankhadip Bose +6 more
doaj +2 more sources
Cytokine Signaling in 2002 New Surprises in the Jak/Stat Pathway [PDF]
Cell, 2002 The importance of Jak-Stat pathway signaling in regulating cytokine-dependent gene expression and cellular development/survival is well established. Nevertheless, advances continue to be made in defining Jak-Stat pathway effects on different cellular ...
Gadina, Massimo +2 more
core +3 more sources
RETRACTED: Cellular functions of spermatogonial stem cells in relation to JAK/STAT signaling pathway [PDF]
Frontiers in Cell and Developmental BiologyThis manuscript comprehensively reviews the interrelationship between spermatogonial stem cells (SSCs) and the JAK/STAT signaling pathway. Spermatogonial stem cells in the testes of male mammals, characterized by their self-renewal and pluripotential ...
Xinyu Guo, Liang Dong, Dingjun Hao
doaj +2 more sources
Parameter inference in mechanistic models of cellular regulation and signalling pathways using gradient matching [PDF]
, 2012 A challenging problem in systems biology is parameter inference in mechanistic models of signalling pathways. In the present article, we investigate an approach based on gradient matching and nonparametric Bayesian modelling with Gaussian processes.
Dondelinger, F. +7 more
core +9 more sources
JAK-STAT Signalling Pathway in Cancer [PDF]
Cancers, 2020 n ...
Andrew J. Brooks, Tracy Putoczki
openaire +5 more sources
The JAK/STAT signaling pathway [PDF]
Journal of Cell Science, 2004 The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies.
Jason S, Rawlings +2 more
openaire +2 more sources
JAK-STAT pathway inhibitors in dermatology [PDF]
Anais Brasileiros de Dermatologia, 2023 The JAK-STAT signaling pathway mediates important cellular processes such as immune response, carcinogenesis, cell differentiation, division and death. Therefore, drugs that interfere with different JAK-STAT signaling patterns have potential indications ...
Hélio Amante Miot +5 more
doaj +1 more source
JAK/STAT pathway: Extracellular signals, diseases, immunity, and therapeutic regimens
Frontiers in Bioengineering and Biotechnology, 2023 Janus kinase/signal transduction and transcription activation (JAK/STAT) pathways were originally thought to be intracellular signaling pathways that mediate cytokine signals in mammals.
Qian Hu +15 more
doaj +1 more source