Results 61 to 70 of about 2,163,748 (287)
The role of JAK/STAT signaling pathway in Systemic Sclerosis
, 2022 This is an Academia Letters (commentary) article in which the role of JAK/STAT signaling pathway in systemic sclerosis is discussed (structured abstract is not applicable)
Domina Petric
core +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Myeloproliferative neoplasms and the JAK/STAT signaling pathway: an overview
Revista Brasileira de Hematologia e Hemoterapia, 2015 Myeloproliferative neoplasms are caused by a clonal proliferation of a hematopoietic progenitor. First described in 1951 as 'Myeloproliferative Diseases' and reevaluated by the World Health Organization classification system in 2011, myeloproliferative neoplasms include polycythemia vera, essential thrombocythemia and primary myelofibrosis in a ...
Freitas, Renata Mendes de +1 more
openaire +5 more sources
Journal of Orthopaedic Translation, 2022 Background: It is well known that appropriate mechanical stimulation benefits tendon-bone (T-B) healing, however, the mechanisms behind this are still uncovered completely.
Yuqian Liu +7 more
doaj +1 more source
Characterization of a gp130 Signaling Receptor Polymorphism [PDF]
, 2013 We previously reported an association between human herpesvirus 8 (HHV-8) seroprevalence and increased prostate cancer risk among men on the Caribbean island of Tobago.
Kercher, Katherine
core
Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk
Molecular Oncology, EarlyView.Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley +1 more source
JAK-STAT in Early Hematopoiesis and Leukemia
Frontiers in Cell and Developmental Biology, 2021 Hematopoietic stem cells (HSCs) produce all the terminally differentiated blood cells and are controlled by extracellular signals from the microenvironment, the bone marrow (BM) niche, as well as intrinsic cell signals.
Eirini Sofia Fasouli, Eleni Katsantoni
doaj +1 more source
Molecular Oncology, EarlyView.Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler +3 more
wiley +1 more source
The role of the JAK/STAT signal pathway in rheumatoid arthritis [PDF]
Therapeutic Advances in Musculoskeletal Disease, 2018 Proinflammatory cytokine activation of the Janus kinase/signal transducers and activators of transcription (JAK/STAT) signal transduction pathway is a critical event in the pathogenesis and progression of rheumatoid arthritis. Under normal conditions, JAK/STAT signaling reflects the influence of negative regulators of JAK/STAT, exemplified by the ...
openaire +2 more sources
Cell Communication and SignalingThe JAK-STAT pathway is an essential signaling mechanism that initiates immune responses against pathogen infections. The intrinsic homeostatic regulation of JAK-STAT signaling is critical for maintaining immune homeostasis.
Hongliang Zuo +7 more
doaj +1 more source