Results 81 to 90 of about 2,163,748 (287)

Basics of Janus kinases: a review

Journal of the Egyptian Women’s Dermatologic Society, 2020
Janus kinases (JAKs) are a group of nonreceptor intracellular tyrosine kinases that could modify cytokine-mediated signals through the JAK-signal transducer and activator of transcription (STAT) pathway. The intracellular signaling pathway JAK/STAT has a
Hanan R Nada, Maha F Elmasry, Dina A El Sharkawy, Sally Mamdouh   +3 more
doaj   +1 more source

Transient JAK/STAT pathway inhibition prevents natural occurring B-ALL development in genetically predisposed Pax5+/- mice

, 2022
Preventing development of childhood B-cell acute lymphoblastic leukemia (B-ALL), a disease with devastating effects, is a longstanding and unsolved challenge.
Isidro-Hernández, Marta, Alemán-Artega, Silvia, Mayado, Andrea, Prieto-Matos, Pablo, Criado, Francisco Javier García, Cobaleda, César, Orfao, Alberto, Yang, Jun J, Oak, Ninad, Riesco, Susana, Alonso-López, Diego, Weiss, Andreas, Nichols, Kim E, Sánchez-García, Isidro, Vicente-Dueñas, Carolina, Cenador, María Begoña García, Buhles, Alexandra, Mann-Ran, Christine, Radimerski, Thomas, De Las Rivas, Javier, Raboso-Gallego, Javier, Sterker, Dario, Casado-García, Ana, Blanco, Oscar, Ramírez-Orellana, Manuel   +24 more
core   +1 more source

Endothelial Cell Proteins as Biomarkers in Susac Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Susac syndrome (SS) is a rare CD8+ T cell–mediated microangiopathy affecting the brain, retina, and auditory labyrinth. Endothelial injury is thought to be a central mechanism; however, no circulating disease biomarkers are known. We performed targeted proteomic profiling to identify circulating endothelial‐associated proteins as ...
Rohit Benjamin, Yue Andy Qi, Ying Hao, Catherine DeMarino, Samuel Darko, Irene Cortese, Daniel S. Reich, María I. Gaitán, Steven Jacobson, Bridgett J. Billioux, Bryan Smith, Avindra Nath   +11 more
wiley   +1 more source

The role of JAK-STAT signaling pathway in early arthritis [PDF]

, 2023
Rheumatoid arthritis (RA) is a systemic, inflammatory, immune-mediated disorder, impacting approximately 1% of the world population. It is characterized by chronic joint inflammation due to accumulation of activated leukocytes in the synovial membrane,
Mariano, Ana Rita Faísca
core  

Image2_E-cadherin acts as a positive regulator of the JAK-STAT signaling pathway during Drosophila oogenesis.tiff

, 2022
The JAK-STAT pathway is evolutionary conserved. The simplicity of this signaling in Drosophila, due to the limited redundancy between pathway components, makes it an ideal model for investigation.
Charlotte Mallart (9606256), Fabienne Chalvet (118391), Mickael Poidevin (138545), Alba Yurani Torres (13286664), Sophie Netter (118395), Anne-Marie Pret (118412), Marianne Malartre (9606259), Jacques Montagne (138559)   +7 more
core   +1 more source

Real‐World Safety and Effectiveness of JAK Inhibitors in Systemic Sclerosis: A Propensity‐Matched Study From the EUSTAR Cohort

Arthritis Care &Research, EarlyView.
Objective JAK inhibitors (JAKi) have shown promising effects in early‐phase studies of systemic sclerosis (SSc). We aimed to assess the safety and explore the effectiveness of JAKi compared to conventional immunosuppressants in SSc. Methods A longitudinal retrospective study of the European Scleroderma Trials and Research Group (EUSTAR) cohort was ...
Stefano Di Donato, Marie‐Elise Truchetet, Marco Minerba, Oliver Distler, Juan José Alegre Sancho, Yolanda Braun‐Moscovici, Christina Bergmann, Petros Sfikakis, Jeska K. de Vries‐Bouwstra, Murray Baron, Silvia Bellando‐Randone, Lorenzo Dagna, Christopher P. Denton, Madelon C. Vonk, Vanessa Smith, Ivan Castellvi, Gabriela Riemekasten, Andra Balanescu, Masataka Kuwana, Maria De Santis, Kamal Solanki, Anastas Batalov, Vahan Mukuchyan, Marco Matucci‐Cerinic, Yannick Allanore, Francesco Del Galdo, Michael Hughes, EUSTAR Collaborators   +27 more
wiley   +1 more source

The role of JAK-STAT signaling pathway and its regulators in the fate of T helper cells

Cell Communication and Signaling, 2017
The Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway plays critical roles in orchestrating of immune system, especially cytokine receptors and they can modulate the polarization of T helper cells.
Farhad Seif, Majid Khoshmirsafa, Hossein Aazami, Monireh Mohsenzadegan, Gholamreza Sedighi, Mohammadali Bahar   +5 more
doaj   +1 more source

Quercetin as a JAK–STAT inhibitor: a potential role in solid tumors and neurodegenerative diseases

Cellular & Molecular Biology Letters, 2022
The Janus kinase–signal transducer and activator of transcription (JAK–STAT) pathway is involved in many immunological processes, including cell growth, proliferation, differentiation, apoptosis, and inflammatory responses.
Hamidreza Zalpoor, Mohsen Nabi-Afjadi, Razieh Forghaniesfidvajani, Chanour Tavakol, Faranak Farahighasreaboonasr, Farid Pakizeh, Vahid Ghobadi Dana, Farhad Seif   +7 more
doaj   +1 more source

Image3_E-cadherin acts as a positive regulator of the JAK-STAT signaling pathway during Drosophila oogenesis.tiff

, 2022
The JAK-STAT pathway is evolutionary conserved. The simplicity of this signaling in Drosophila, due to the limited redundancy between pathway components, makes it an ideal model for investigation.
Charlotte Mallart (9606256), Fabienne Chalvet (118391), Mickael Poidevin (138545), Alba Yurani Torres (13286664), Sophie Netter (118395), Anne-Marie Pret (118412), Marianne Malartre (9606259), Jacques Montagne (138559)   +7 more
core   +1 more source

Targeting CD300a Signaling With a Phosphatidylserine‐Presenting Hydrogel Rescues Macrophage Dysfunction and Accelerates Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the proposed mechanism: PEG/RGD‐PSLs mimic apoptotic cells to engage PS receptors (notably CD300a), transducing an inhibitory signal that suppresses the MyD88/NF‐κB pathway, leading to global anti‐inflammatory and pro‐reparative effects.
Lele Wu, Xuetong Hao, Yang Zou, Xinglin Chen, Junyan Kong, Chunning Gu, Wenjie Ma, Zhongjun Yang, Huifen Liu, Mengmeng Liu, Xin Tong   +10 more
wiley   +1 more source