Results 11 to 20 of about 958,890 (240)

A Review on the Safety of Using JAK Inhibitors in Dermatology: Clinical and Laboratory Monitoring

Dermatologic Therapy, 2023
Janus kinase (JAK) inhibitors are disease-modifying agents with efficacy in treating a spectrum of burdensome dermatologic conditions. The US Food and Drug Administration (FDA) recently placed a black box warning on this class of medications due to ...
Christeen Samuel, Hannah L Cornman, Anusha Kambala, S. Kwatra   +3 more
semanticscholar   +1 more source

The JAK–STAT pathway in keloid pathogenesis: a systematic review with qualitative synthesis

Experimental Dermatology, Volume 32, Issue 5, Page 588-598, May 2023., 2023
Abstract Keloid tissues contain inflammatory cells and upregulated pro‐inflammatory cytokines. The Janus kinase (JAK)‐signal transducer and activator of transcription (STAT) pathway mediate cellular responses to these cytokines. We performed a systematic review on the role of the JAK–STAT pathway in keloid pathogenesis and the evidence for JAK–STAT ...
Qi Yin, Albert Wolkerstorfer, Oren Lapid, Frank B. Niessen, Paul P. M. Van Zuijlen, Susan Gibbs   +5 more
wiley   +1 more source

Estradiol inhibits phosphorylation of JAK/STAT, PI3K/AKT and expression of IL-17A in mouse mononuclear cells treated with IL-36β

Pifu-xingbing zhenliaoxue zazhi, 2023
Objective To investigate the effects of β-estradiol (E2) on the phosphorylation of JAK/STAT, PI3K/AKT signaling pathways and the expression of IL-17A in mouse spleen mononuclear cells treated with IL-36β. Methods The spleens were isolated from female SPF
Shuang LIU, Shanshan YANG, Chunchan ZHENG, Sujun LUO, Na WEI, Sirui LI, Jianqiang SHI, Rongyi CHEN   +7 more
doaj   +1 more source

JAK-STAT signaling in inflammation and stress-related diseases: implications for therapeutic interventions

Molecular Biomedicine, 2023
The Janus kinase-signal transducer and transcription activator pathway (JAK-STAT) serves as a cornerstone in cellular signaling, regulating physiological and pathological processes such as inflammation and stress.
Alexey Sarapultsev, Evgenii Gusev, M. Komelkova, I. Utepova, Shanshan Luo, Desheng Hu   +5 more
semanticscholar   +1 more source

STAT3 and REDD1: an unconventional story of gene repression

The FEBS Journal, Volume 290, Issue 7, Page 1735-1739, April 2023., 2023
Compared with the canonical mechanisms of activating gene expression, the non‐canonical actions of the transcription factor STAT3 have not received much attention. Köhler et al. highlight a novel mechanism of STAT3 repression over the REDD1 gene. These results are essential for understanding the role of the REDD1 protein and the effects of this precise
Pol Garcia‐Segura, Cristina Malagelada
wiley   +1 more source

Design for Dynamic Challenges: Key Attributes of Designers for Leading Interdisciplinary Research and Projects

Diseña, 2018
The world seems more burdened with large-scale global problems than ever before. One such challenge is to reverse the growing incidence of mental health issues, particularly in our cities.
Jak Spencer
doaj   +9 more sources

Inhibition of the JAK2/STAT3 Pathway Attenuates D-Galactose-Induced Nucleus Pulposus Cell Senescence and Intervertebral Disc Degeneration. [PDF]

Stem Cells Int
Objective This study aimed to investigate the effect of Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) pathway inhibition on D‐galactose (D‐gal)‐induced senescence in nucleus pulposus cells (NPCs) and its potential to delay intervertebral disc degeneration (IVDD), as well as to investigate the underlying mechanisms ...
Liang W, Zhang S, Cai X, Wang Y, Hao H, Ya K, Sheng J, Sheng W.   +7 more
europepmc   +2 more sources

Lineage plasticity in prostate cancer depends on JAK/STAT inflammatory signaling

Science, 2022
Drug resistance in cancer is often linked to changes in tumor cell state or lineage, but the molecular mechanisms driving this plasticity remain unclear. Using murine organoid and genetically engineered mouse models, we investigated the causes of lineage
J. Chan, S. Zaidi, J. Love, Jimmy L. Zhao, M. Setty, K. Wadosky, A. Gopalan, Z. Choo, S. Persad, Jungmin Choi, Justin Laclair, K. Lawrence, O. Chaudhary, Tianhao Xu, I. Masilionis, I. Linkov, Shangqian Wang, Cindy J Lee, A. Barlas, M. Morris, L. Mazutis, R. Chaligné, Yu Chen, D. Goodrich, W. Karthaus, D. Pe’er, C. Sawyers   +26 more
semanticscholar   +1 more source

The driver role of JAK‐STAT signalling in cancer stemness capabilities leading to new therapeutic strategies for therapy‐ and castration‐resistant prostate cancer

Clinical and Translational Medicine, Volume 12, Issue 8, August 2022., 2022
Activated JAK‐STAT signalling cascade plays a critical role in the onset of therapy‐ and castration‐resistant disease that is associated with stem cell plasticity. IFIT5, a downstream effector of JAK‐STAT signalling pathway, exhibits a new functional role in modulating stemness transcriptional factors (such as BMI1, NANOG and SOX2) by promoting ...
U‐Ging Lo, Yu‐An Chen, Junjie Cen, Su Deng, Junghang Luo, Haiyen Zhau, Lin Ho, Chih‐Ho Lai, Ping Mu, Leland W.K. Chung, Jer‐Tsong Hsieh   +10 more
wiley   +1 more source

A Comprehensive Overview of Globally Approved JAK Inhibitors

Pharmaceutics, 2022
Janus kinase (JAK) is a family of cytoplasmic non-receptor tyrosine kinases that includes four members, namely JAK1, JAK2, JAK3, and TYK2. The JAKs transduce cytokine signaling through the JAK-STAT pathway, which regulates the transcription of several ...
Ahmed M. Shawky, F. Almalki, Ashraf N. Abdalla, A. Abdelazeem, A. Gouda   +4 more
semanticscholar   +1 more source