Results 21 to 30 of about 958,890 (240)

Pharmacologic screen identifies active combinations with BET inhibitors and LRRK2 as a novel putative target in lymphoma

eJHaem, Volume 3, Issue 3, Page 764-774, August 2022., 2022
Abstract Inhibitors of the Bromo‐ and Extra‐Terminal domain (BET) family proteins have strong preclinical antitumor activity in multiple tumor models, including lymphomas. Limited single‐agent activity has been reported in the clinical setting. Here, we have performed a pharmacological screening to identify compounds that can increase the antitumor ...
Filippo Spriano, Giulio Sartori, Chiara Tarantelli, Marilia Barreca, Gaetanina Golino, Andrea Rinaldi, Sara Napoli, Michele Mascia, Lorenzo Scalise, Alberto J. Arribas, Luciano Cascione, Emanuele Zucca, Anastasios Stathis, Eugenio Gaudio, Francesco Bertoni   +14 more
wiley   +1 more source

JAK inhibitor: Introduction

Indian Journal of Dermatology, Venereology and Leprology, 2023
The Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway is a key regulatory signaling system for cellular proliferation, differentiation, and apoptosis. In addition, JAK signaling pathway plays critical roles in orchestrating immune response through its interactions with the cytokine receptors and the transcriptions ...
Siba P, Raychaudhuri, Smriti K, Raychaudhuri   +1 more
openaire   +2 more sources

The Role of JAK/STAT Pathway in Fibrotic Diseases: Molecular and Cellular Mechanisms

Biomolecules, 2023
There are four members of the JAK family and seven of the STAT family in mammals. The JAK/STAT molecular pathway could be activated by broad hormones, cytokines, growth factors, and more.
Jia Liu, Faping Wang, F. Luo
semanticscholar   +1 more source

IFN‐α/β‐mediated NK2R expression is related to the malignancy of colon cancer cells

Cancer Science, Volume 113, Issue 8, Page 2513-2525, August 2022., 2022
IFN‐α/β induced neurokinin 2 receptor (NK2R), a G protein‐coupled receptor for neurokinin A in a JAK1/2‐dependent manner. NK2R expression was related to the tumorigeneis and mietastatic colonization of colon cancer cells. Therefore, NK2R blockade will be a promising strategy for colon cancers.
Huihui Xiang, Yujiro Toyoshima, Weidong Shen, Xiangdong Wang, Naoki Okada, Shuhei Kii, Ko Sugiyama, Toshihiro Nagato, Hiroya Kobayashi, Kazuho Ikeo, Shinichi Hashimoto, Mishie Tanino, Akinobu Taketomi, Hidemitsu Kitamura   +13 more
wiley   +1 more source

Safety and efficacy of fedratinib, a selective oral inhibitor of Janus kinase‐2 (JAK2), in patients with myelofibrosis and low pretreatment platelet counts

British Journal of Haematology, Volume 198, Issue 2, Page 317-327, July 2022., 2022
Summary Fedratinib, an oral Janus kinase‐2 (JAK2) inhibitor, is approved for patients with myelofibrosis (MF) and platelet counts ≥50 × 109/l, based on outcomes from the phase 3, placebo‐controlled JAKARTA trial in JAK‐inhibitor‐naïve MF, and the phase 2, single‐arm JAKARTA2 trial in patients previously treated with ruxolitinib.
Claire N. Harrison, Nicolaas Schaap, Alessandro M. Vannucchi, Jean‐Jacques Kiladjian, Francesco Passamonti, Sonja Zweegman, Moshe Talpaz, Srdan Verstovsek, Shelonitda Rose, Jun Zhang, Oumar Sy, Ruben A. Mesa   +11 more
wiley   +1 more source

C/EBPβ regulates the JAK/STAT signaling pathway in triple‐negative breast cancer

FEBS Open Bio, Volume 11, Issue 4, Page 1250-1258, April 2021., 2021
C/EBPβ is a b‐ZIP transcription factor. Here, we present evidence that C/EBPβ is specifically overexpressed in human TNBC samples, but not in non‐TNBC samples. C/EBPβ depletion dramatically suppresses TNBC cell growth, migration, invasion, and colony formation ability.
Shu Wang, Dian Xia, Xianzhi Wang, Haowei Cao, Chaoshen Wu, Zhaoran Sun, Daoyong Zhang, Hao Liu   +7 more
wiley   +1 more source

The Role of the JAK/STAT Signaling Pathway in the Pathogenesis of Alzheimer’s Disease: New Potential Treatment Target

International Journal of Molecular Sciences, 2023
Alzheimer’s disease is characterized by the accumulation of amyloid plaques and neurofibrillary tangles in the brain. However, emerging evidence suggests that neuroinflammation, mediated notably by activated neuroglial cells, neutrophils, and macrophages,
M. Rusek, Joanna Smith, K. El-Khatib, Kennedy Aikins, S. Czuczwar, R. Pluta   +5 more
semanticscholar   +1 more source

JAK inhibitors: A new dawn for oral therapies in inflammatory bowel diseases

Frontiers in Medicine, 2023
Inflammatory bowel disease (IBD) is a chronic immune-mediated condition of the gastrointestinal tract that requires chronic treatment and strict surveillance.
C. Herrera-deGuise, X. Serra-Ruiz, E. Lastiri, N. Borruel   +3 more
semanticscholar   +1 more source

IL-6/JAK/STAT3 Signaling in Breast Cancer Metastasis: Biology and Treatment

Frontiers in Oncology, 2022
Breast cancer is the most commonly diagnosed cancer in women. Metastasis is the primary cause of mortality for breast cancer patients. Multiple mechanisms underlie breast cancer metastatic dissemination, including the interleukin-6 (IL-6)-mediated ...
Sara G Manore, Daniel L Doheny, Grace L Wong, H. Lo   +3 more
semanticscholar   +1 more source

JAK3 as an emerging target for topical treatment of inflammatory skin diseases [PDF]

, 2016
The recent interest and elucidation of the JAK/STAT signaling pathway created new targets for the treatment of inflammatory skin diseases (ISDs). JAK inhibitors in oral and topical formulations have shown beneficial results in psoriasis and alopecia ...
Alves de Medeiros, Ana, De Schepper, Sofie, Desmet, Eline, Lambert, Jo, Speeckaert, Reinhart, Van Gele, Mireille   +5 more
core   +2 more sources