Results 1 to 10 of about 60,858 (147)
Maladaptive somatic gene rescue as predisposition to JAK2 molecular abnormalities? Insights from an Israeli family [PDF]
Annals of HematologyEosinophilia associated with PCM1::JAK2 fusion and classic Philadelphia (Ph)-negative myeloproliferative neoplasms (MPN) are both clonal disorders caused by a dysregulation of the JAK2 signaling pathway.
Oscar Borsani +3 more
doaj +2 more sources
An in vitro investigation of the apoptosis-inducing activity of corosolic acid in breast cancer cells [PDF]
Iranian Journal of Basic Medical Sciences, 2023 Objective(s): Breast cancer is the most prevalent cancer among females with different molecular subtypes. Corosolic acid is a pentacyclic triterpenoid with anti-cancer properties.
Saade Abdalkareem Jasim +11 more
doaj +1 more source
Journal of Applied Hematology, 2023 INTRODUCTION: Serum erythropoietin (S. EPO) continues to be a minor diagnostic criterion for discriminating polycythemia vera (PV) from other causes of erythrocytosis.
Ruchi Gupta +7 more
doaj +1 more source
Türk Patoloji Dergisi, 2021 Inflammatory pseudotumor-like follicular/fibroblastic dendritic cell (FDC/FRC) sarcoma is an extremely rare neoplasm of the spleen associated with EBV and characterized by spindle cell morphology, dense mixed chronic inflammatory background, and a broad ...
Bryan MORALES-VARGAS +2 more
doaj +1 more source
Hematology/Oncology and Stem Cell Therapy, 2022 Objective/Background: Recurrent somatic mutations in the JAK2, calreticulin (CALR), and the MPL genes are described as drivers of BCR-ABL1-negative myeloproliferative neoplasms (MPN) that includes polycythemia vera (PV), essential thrombocytosis (ET ...
Madhavi Maddali +14 more
doaj +1 more source
Effect of leptin on the growth and expression of STAT3 in yak mammary epithelial cells [PDF]
Veterinary World, 2022 Background and Aim: Leptin (LEP) is an autocrine and paracrine factor produced by the fat pad and acinar epithelial cells of the breast. This study aimed to investigate the effects of LEP on yak mammary epithelial cells (YMECs) and the expression of ...
Baoxia Dong +6 more
doaj +1 more source
Overt-stage primary myelofibrosis after COVID-19 infection: a case report [PDF]
World Cancer Research Journal, 2022 OBJECTIVE: Primary Myelofibrosis (PMF) is an uncommon hematological condition where the bone marrow becomes progressively fibrotic, resulting in anemia, extramedullary hematopoiesis, and splenomegaly.
P. Darmada +3 more
doaj +1 more source
Medicina Clínica (English Edition), 2016 Pharmacological inhibition of the kinase activity of JAK proteins can interfere with the signaling of immunomodulatory cytokines and block the constitutive activation of the JAK-STAT pathway that characterizes certain malignancies, including chronic myeloproliferative neoplasms.
Juan Carlos, Hernández Boluda +2 more
openaire +5 more sources
Case Reports in Oncology, 2019 Myelofibrosis (MF) can occur due to a wide variety of causes including malignant lymphoma. We report a case of splenic marginal zone lymphoma complicated by MF mimicking primary myelofibrosis (PMF).
Miyuki Tsutsui +3 more
doaj +1 more source
Drugs in Context, 2020 The Janus kinases (JAK) are a group of molecules, composed of JAK1, JAK2, JAK3, and tyrosine kinase 2 (TYK2), which are key components within the JAK–signal transducers and activators of transcription pathway, where cytokine receptor signaling takes ...
Novin Nezamololama +3 more
doaj +1 more source