Results 201 to 210 of about 60,957 (246)

Natural triterpenoid Ardisiacrispin B attenuates colitis-associated cancer via JAK2/STAT3 pathway and gut microbiota modulation. [PDF]

Nat Prod Bioprospect
Ullah H, Cui H, Li Y, Ye B, Peng W, Ruan Y, Dai W, Ma C, Hu X.   +8 more
europepmc   +1 more source

Wnt Signaling Downregulation Mediates T Cell Apoptosis Following OKT3‐Induced T Cell Activation in Preclinical Models

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
In OKT3‐treated human PBMCs, Wnt signaling was downregulated, and co‐treatment with the Wnt activator CHIR99021 reduced T cell activation and apoptosis. In humanized mice, transcriptomic profiling revealed upregulation of genes associated with T cell activation, cytokine and ROS production, and apoptosis, with downregulation of canonical Wnt signaling.
Myeongjin Choi, Duhyeon Park, Da‐Hee Lee, Chang Hoon Choi, Minseong Jo, Seo Yule Jeong, Seung Yeon Lim, Daeui Park, Kyoung‐Sik Moon   +8 more
wiley   +1 more source

FCGBP Promotes Glioma Growth by Regulating JAK2/STAT3/c-Myc Pathway. [PDF]

Cancer Med
Zheng J, Rao YX, Zheng H, Shi LL.
europepmc   +1 more source

Regulation of pyruvate dehydrogenase complex: Dancing to different drums in cancer

International Journal of Cancer, Volume 158, Issue 6, Page 1464-1480, 15 March 2026.
Abstract Mechanisms governing the regulation of pyruvate dehydrogenase complex (PDC) are markedly modified in cancer cells compared to normal cells. PDC activity in normal cells is controlled by the reversible phosphorylation of three serine residues by dedicated kinases and phosphatases.
Mulchand S. Patel, Todd C. Rideout
wiley   +1 more source

A simple compound prioritization method for drug discovery considering multi-target binding.

Digit Discov
Kubincová A, Mobley DL.
europepmc   +1 more source

Mechanism by which Icariin suppresses pulmonary metastasis in triple-negative breast cancer through downregulation of the SPDL1/JAK2/STAT3 signaling pathway. [PDF]

Cancer Cell Int
Xiao Z, Yang Z, Li X, Chen X, Li J, He Y, Li W, Wang J.   +7 more
europepmc   +1 more source

Imperatorin Mitigates Rosacea‐Like Inflammation by Modulating the Crosstalk Between JNK1 and STAT1

The FASEB Journal, Volume 40, Issue 5, 15 March 2026.
IMP treatment disrupts the interaction between JNK1 and STAT1, thereby attenuating STAT1 activity. This interference subsequently diminishes the phosphorylation and nuclear translocation of STAT1, which ultimately results in a reduced production of inflammatory cytokines and chemokines.
Xiaoxue Wang, Zexin Zhu
wiley   +1 more source

Should <i>JAK2</i> V617F Mutation Testing be Inducted into Routine Thrombophilia Screening? [PDF]

Clin Appl Thromb Hemost
Langabeer SE.
europepmc   +1 more source

Frequent NPM1 mutation, monoblastic/monocytic origin and prognostic significance of organ and system involvement in myeloid sarcoma: a multicenter study

The Journal of Pathology: Clinical Research, Volume 12, Issue 2, March 2026.
Abstract Myeloid sarcoma (MS) is a tumorous extramedullary proliferation of blast or blast equivalent cells (e.g., promonocytes or promyelocytes). The most frequent cutaneous presentation is often referred to as leukemia cutis (LC). These lesions, especially without the clinical context of a known bone marrow disease, pose a differential diagnostic ...
Alex Jenei, Béla Kajtár, Tamás László, Hazem A Juratli, Livia Vida, Ágota Szepesi, Réka Mózes, Botond Timár, Jörg Halter, Stefan Dirnhofer, Alexandar Tzankov   +10 more
wiley   +1 more source