Results 191 to 200 of about 79,208 (292)

Myelodysplasia‐Related Gene Mutation Burden Is Associated With Complete Remission After Induction Therapy in Acute Myeloid Leukemia, Not Otherwise Specified: Reclassification According to the Updated Classifications

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction Updated classifications incorporating myelodysplasia‐related (MR) gene mutations reclassify many cases previously diagnosed as acute myeloid leukemia, not otherwise specified (AML, NOS). We evaluated the clinical significance of MR gene mutation burden, defined by mutation number and variant allele frequency (VAF), in AML, NOS ...
Taegeun Lee, Daehyun Chu, Miyoung Kim, Young‐Uk Cho, Sang‐Hyun Hwang, Je‐Hwan Lee, Yunsuk Choi, Eun‐Ji Choi, Ho Joon Im, Hyery Kim, Seongsoo Jang   +10 more
wiley   +1 more source

Deep learning differentiates myeloproliferative neoplasms and predicts JAK2 and CALR mutations from bone marrow smears. [PDF]

Ann Hematol
Eckardt JN, Reddy CBV, Hauspurg H, Riechert S, Schmittmann T, Srivastava I, Winter S, Sockel K, Badstübner M, Bornhäuser M, Tiemann M, Middeke JM.   +11 more
europepmc   +1 more source

Interleukin‐12: Central Roles in Immune Regulation and Disease Therapy

Immunology &Cell Biology, EarlyView.
IL‐12 levels are tightly regulated to balance effective protective immunity against infections and cancer with the risk of excessive inflammation and autoimmune disease. Both insufficient and excessive IL‐12 activity can therefore be detrimental, highlighting the importance of precisely controlling its production and signaling. ABSTRACT Interleukin‐12 (
Anthi Psoma, Geert van den Bogaart
wiley   +1 more source

Comprehensive High-Sensitivity Mutation Profiling in MPNs: Diagnostic and Prognostic Implications. [PDF]

Cancers (Basel)
Kim N, Kang Y, Kook HW, Chung H, Jang JE, Lee ST, Song J, Kim JS, Choi JR, Cheong JW, Shin S.   +10 more
europepmc   +1 more source

Tissue Resident Memory Cells: Friend or Foe?

Immunology, EarlyView.
Tissue‐resident memory T cells (TRM cells) are specialised immune cells in barrier tissues like the lungs, skin and gut, providing rapid host defence and tumour surveillance. Their retention and differentiation are regulated by molecules such as CD69, CD103 and TGF‐β. Dysregulation of TRM cells can lead to chronic activation, driving conditions such as
Chidimma F. Chude, Jude E. Uzonna, Janilyn Arsenio   +2 more
wiley   +1 more source

Molecular Mechanisms and Therapeutic Targeting of the STAT3 Signaling Axis in Vascular Smooth Muscle Cell Phenotypic Switching and Vascular Remodeling. [PDF]

Cells
Zheng T, Li H, Yao L, Zhang Y, Feng L, Yang D.   +5 more
europepmc   +1 more source

Neutrophilia and the JAK2 V617F Mutation

Pathology & Oncology Research, 2017
Stephen E, Langabeer, Karl, Haslam
openaire   +2 more sources

Olutasidenib Alone or in Combination With Azacitidine as a Bridge to Transplant in Relapsed/Refractory mIDH1 AML

European Journal of Haematology, EarlyView.
Shira N. Dinner, Justin M. Watts, Jorge E. Cortes, Jay Yang, Maria R. Baer, Gail J. Roboz, Karen W. L. Yee, Antonio Curti, David C. Taussig, Jürgen Krauter, Thomas Prebet, Hua Tian, Aaron D. Sheppard, Pierre Peterlin, Carolyn Grove, Christian Récher, Stéphane de Botton   +16 more
wiley   +1 more source

Ruxolitinib cream in adults with moderate atopic dermatitis after failure of other topicals: A randomized trial

Journal of the European Academy of Dermatology and Venereology, EarlyView.
In adults with moderate AD post‐TCS and ‐TCI, who may otherwise be eligible for systemic therapy, 1.5% ruxolitinib cream improved clinical signs and symptoms in the TRuE‐AD4 study. Abstract Background In patients with moderate atopic dermatitis (AD), topical corticosteroids (TCS) and topical calcineurin inhibitors (TCI) often do not sufficiently ...
José Manuel Carrascosa, Vimal H. Prajapati, H. Chih‐ho Hong, Viktoria Eleftheriadou, Athanasios Tsianakas, Alexander A. Navarini, Ketty Peris, Eingun James Song, Raj Chovatiya, Sébastien Barbarot, Konstantin Popovic, Haq Nawaz, Qian Li, Vivek Purohit, Andreas Wollenberg   +14 more
wiley   +1 more source

Exploring the mechanism of action of tripterygium glycosides tablets in the treatment of rheumatoid arthritis based on the Lnc-ENST00000602558/IGF1 signaling pathway. [PDF]

Front Pharmacol
Fang JY, Liu MX, Yang YN, Xie CX, Liu CP, Zhu CH, Hu J, Li W, Lv L, Wang YH, Zhu ZH, Wang HL.   +11 more
europepmc   +1 more source