Results 181 to 190 of about 73,607 (303)

Tumors with amplifications of JAK2 at the 9p24 loci in TNBC demonstrate JAK2-specific dependency

, 2016
Amplifications at 9p24 have been identified in breast cancer and other malignancies, but the culprit genes that apply oncogenic functionality within this locus remain unclear.
Arteaga, Carlos L, Balko, Justin M
core  

Hematopoietic JAK2V617F mutation-induced reprogramming of blood and bone marrow megakaryocytes. [PDF]

Blood Adv
Lu S, Karkempetzaki AI, Huang N, Zhang C, Murphy GJ, Ravid K.   +5 more
europepmc   +1 more source

A novel JAK1 variant in chronic eosinophilic leukaemia with response to benralizumab

British Journal of Haematology, EarlyView.
Isabel C. Vallecillo‐Viejo, Michael D. Claiborne, Charles F. Anderson, Samantha Shafer, Alan Saven, Bryce A. Seifert, Morgan Similuk, Magdalena Walkiewicz, Irina Maric, Pia R. Crespo, Lori Broderick, Andrew A. White, Amy D. Klion   +12 more
wiley   +1 more source

<i>Toxoplasma gondii</i> KCR is a Noncanonical Modulator of CSF2 Signaling that Targets the CSF2Rα-JAK2/STAT5 Axis. [PDF]

Transbound Emerg Dis
Mei J, Pu X, Zhang M, Liu Y, Meng C, Xu L, Song X, Yan R, Li X, Lu M.   +9 more
europepmc   +1 more source

The JAK2 V617F mutation and thrombocytopenia

Hematology/Oncology and Stem Cell Therapy, 2017
Langabeer, Stephen E., Haslam, Karl
openaire   +2 more sources

Irradiated Liver Cancer Cell Vaccine Transfected With GM‐CSF Induces Specific and Long‐Lasting Anti‐tumour Immunity Through the Synergistic Effect of Oxidised mtDNA and GM‐CSF

Cell Proliferation, EarlyView.
Song et al. developed an mGM‐CSF‐loaded, liver cancer cell‐based vaccine that potently activated dendritic cells and elicited tumour‐specific T cell responses. Mechanistically, radiation‐induced oxidative damage to mitochondrial DNA in cancer cells triggers the cGAS‐STING pathway in DCs, which synergizes with mGM‐CSF‐driven JAK2‐STAT3 signalling to ...
Zhiruo Song, Yujie Jiang, Yu Zhang, Danyi Ao, Chunjun Ye, Xiya Huang, Yingqiong Zhou, Hanle Yang, Ruolan Xia, Jiayuan Ai, Dandan Wan, Aiping Tong, Yuquan Wei, Xuemei He, Aqu Alu, Xiawei Wei   +15 more
wiley   +1 more source

A single <i>JAK2</i>-V617F hematopoietic stem cell can initiate myeloproliferative neoplasm when transplanted into non-conditioned recipient mice. [PDF]

Hemasphere
Kimmerlin Q, Hilpert M, Hansen N, Guy A, Usart M, Stetka J, Sobieralski P, Almeida Fonseca T, Hao-Shen H, Skoda RC.   +9 more
europepmc   +1 more source

Single‐Cell Virtual Perturbation Screening Identifies STAT3 as a Key Regulator of Dentinogenesis

Cell Proliferation, EarlyView.
STAT3 promotes odontoblast differentiation in dental mesenchymal cells by transcriptionally regulating WNT2B via the canonical Wnt/β‐catenin signalling pathway. These findings elucidate a mechanism underlying dentine development. ABSTRACT Dentine formation constitutes a physiological process precisely regulated by signal transduction modules governing ...
Yanfei Zhu, Hongyuan Xu, Zijian Zhang, Siyuan Sun, Zihan Huang, Xin Gao, Houwen Pan, Xiangru Huang, Yuanqi Liu, Xinyu Wang, Hanbin Jia, Qinggang Dai, Lingyong Jiang   +12 more
wiley   +1 more source

Structure-Based Identification of JAK1-Selective Candidates Using Ensemble Docking and Interaction Analysis. [PDF]

Pharmaceuticals (Basel)
Stoian N, Avram S, Halip L.
europepmc   +1 more source

A Specific tRNA Half, 3'tiRNA‐GlyGCC, Regulates Hypoxic Pulmonary Artery Smooth Muscle Cell Proliferation via Myrf‐Mediated Endoplasmic Reticulum Stress

Cell Proliferation, EarlyView.
A schematic diagram illustrating how 3′tiRNA‐GlyGCC promotes the endoplasmic reticulum stress (ERS) and proliferation in hypoxic pulmonary artery smooth muscle cells (PASMCs) by inhibiting the expression of myelin regulatory factor (Myrf), ultimately leading to pulmonary hypertension (PH).
Lixin Zhang, Xiaoyu Guan, Xiangrui Zhu, Yingying Hao, Ya Xu, Hao Yuan, Danni Gao, Hongxia Du, Jiayu Li, Weiwei Cao, Cui Ma, Xiaoying Wang   +11 more
wiley   +1 more source