Results 241 to 250 of about 73,607 (303)

Severe Toxicosis Secondary to Accidental Oclacitinib Ingestion in Three Cats

Journal of Veterinary Emergency and Critical Care, EarlyView.
ABSTRACT Objective To describe the clinical course, outcome, necropsy findings, possible mechanisms of toxicosis, and treatment implications for three cats with acute kidney injury and associated systemic signs secondary to accidental oclacitinib ingestion.
Jessica Kielb Basile, Sara C. Lister
wiley   +1 more source

TTPAL inhibits the progression of breast cancer and reprograms tumor-associated macrophages by inhibiting JAK2/STAT3 signaling pathway. [PDF]

Breast Cancer Res
Du L, Zhu L, Yang Y, Pan L, Lei T, Zhang J, Yao S, Luo G, Zhang X.   +8 more
europepmc   +1 more source

Muscle wasting in cancer cachexia: Mechanisms and the role of exercise

Experimental Physiology, EarlyView.
Abstract Cancer cachexia (CC) is a multifactorial disease marked by a severe and progressive loss of lean muscle mass and characterized further by inflammation and a negative energy/protein balance, ultimately leading to muscle atrophy and loss of muscle tissue.
Zoe P. Libramento, Louisa Tichy, Traci L. Parry   +2 more
wiley   +1 more source

Δ9 Tetrahydrocannabinol and cannabis extracts differentially improve adipoinsular dysfunction in diet‐induced obesity

The Journal of Physiology, EarlyView.
Abstract figure legend THC and extract administered to diet‐induced obese mice reduced body weight and fat storage. Extract, but not THC, improved glucose clearance by a mechanism that may include restoring adipoinsular function. Abstract Diet‐induced obesity (DIO) is associated with dysregulated adipoinsular axis and endocannabinoid system (eCBS ...
Bryant Avalos, Martin Olmos, Courtney P. Wood, Camila Alvarez, Haley M. Read, Parima Udompholkul, Theodore Garland Jr, Nicholas V. DiPatrizio   +7 more
wiley   +1 more source

Sex‐Modulated TACSTD2 Methylation and Hormone‐Receptor Axis Interactions in Glioblastoma: Insights Toward Mechanistic Understanding

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
Sex‐stratified analyses of the TCGA and CGGA cohorts have identified promoter‐proximal TACSTD2 CpG sites where methylation shows opposite survival associations in males and females, is independent of copy number, and correlates with TACSTD2 expression.
Tahreem Fatima
wiley   +1 more source

Sphingosine‐1‐Phosphate Receptor 1 Regulates Competition Dependent Astrocyte Morphogenesis and Tiling in Murine Cortex

Glia, Volume 74, Issue 8, August 2026.
Neuronal contact‐induced expression of S1PR1 in astrocytes is regulated by JAK‐STAT3 signaling. Astrocytic S1PR1 modulates cortical astrocyte morphogenesis. Astrocytic S1PR1 regulates astrocyte territorial overlap/tiling in a competition dependent manner.
Jean Patrick M. Gonzales, Connor Tuck, Surya Chandra Rao Thumu, Soha Munir, Jaden Harris, Hunain (Zeik) Tariq, Paul Marcelli, Oscar Dominguez, Kaviya Suriyakumar Anbazagan, Sandeep K. Singh   +9 more
wiley   +1 more source

Hybrid Cell Membrane‐Coated NIR‐Photodegradable Carbon Nitride Nanozymes for Mangiferin Dual‐Targeted Delivery and Gas Mild Photothermal Immunotherapy Against Liver Fibrosis via the HIF‐1α/HSP27 Axis

Carbon Neutralization, Volume 5, Issue 4, July 2026.
We developed HMCCNs@MAN, a biomimetic drug–gas codelivery platform for precise mild photothermal immunotherapy of liver fibrosis. Coated with hybrid macrophage‐aHSC membranes, it enables dual‐targeted delivery of MAN to the hepatic fibrosis site. Under NIR laser irradiation, HMCCNs@MAN can generate oxygen, release MAN, and produce heat.
Ming‐Xuan Liu, Yue Yang, Xin‐Ru Zhao, Su‐Yun Zhang, Yu‐Ting Cai, Nan Zhang, Jue Wang, Ke‐Yang Xu, Zi‐Ming Zhao, Qi‐Biao Wu   +9 more
wiley   +1 more source

What's Your Diagnosis? A Case of Extreme Thrombocytosis in a Dog

Veterinary Clinical Pathology, EarlyView.
Stephanie F. Anderson, King Long Hannah Lee, Megan Dietz, Sarah Guess, Laura White, Mara S. Varvil   +5 more
wiley   +1 more source

Whole Blood Transcriptomic Response to Perioperative Dexamethasone in Total Knee Arthroplasty: A Targeted Panel Analysis

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 6, July 2026.
ABSTRACT Background Changes in the transcriptome of immune cells are predictive of clinical outcomes. These effects may be surgery‐specific and possibly modulated by glucocorticoids. We investigated the immune response and the impact of dexamethasone on the response in patients undergoing total knee arthroplasty (TKA). Methods The transcript levels (n =
Asger Krog Mølgaard, Kasper Smidt Gasbjerg, Lukas Balsevicius, Britt Cappelen, Adile Orhan, Helin Yikilmaz Pardes, Ole Mathiesen, Thomas Litman, Daniel Hägi‐Pedersen, Ismail Gögenur   +9 more
wiley   +1 more source

Positive and Negative Cardiovascular Effects of JAK Inhibitors in Inflammation

ACR Open Rheumatology, Volume 8, Issue 6, June 2026.
Chronic inflammation, characteristic of many autoimmune diseases, such as rheumatoid arthritis (RA), or myeloproliferative neoplasms (MPNs), is an independent driver of accelerated cardiovascular (CV) risk, primarily through proinflammatory cytokines that induce atherosclerosis and endothelial dysfunction.
Aliki Zavoriti, Pierre Miossec
wiley   +1 more source