Results 91 to 100 of about 577,308 (213)

Carotid artery stenting in JAK2 V617F-positive essential thrombocythemia with symptomatic internal carotid artery stenosis: a case report

Frontiers in Cardiovascular Medicine
Essential thrombocythemia (ET) is a myeloproliferative neoplasm (MPN) characterized by abnormal megakaryocyte proliferation and a markedly elevated platelet count, which predisposes patients to thrombotic or hemorrhagic events.
Minghui Du, Minghui Du, Yinbao Hu, Zhigang Liang, Zhigang Liang, Zhigang Liang   +5 more
doaj   +1 more source

Analysis of phenotype and outcome in essential thrombocythemia with CALR or JAK2 mutations

Haematologica, 2015
The JAK2 V617F mutation, the thrombopoietin receptor MPL W515K/L mutation and calreticulin (CALR) mutations are mutually exclusive in essential thrombocythemia and support a novel molecular categorization of essential thrombocythemia.
Carla Al Assaf, Florence Van Obbergh, Johan Billiet, Els Lierman, Timothy Devos, Carlos Graux, Anne-Sophie Hervent, Jan Emmerechts, Thomas Tousseyn, Pascale De Paepe, Petros Papadopoulos, Lucienne Michaux, Peter Vandenberghe   +12 more
doaj   +1 more source

The molecular pathogenesis of myeloproliferative neoplasms

, 2010
Myeloproliferative neoplasms (MPNs) are a heterogeneous group of haematological stem cellmalignancies characterised by proliferation of one or more cells of the myeloid lineage.
Jones, Amy Victoria
core   +1 more source

The effect of the JAK2 V617F mutation on PRV-1 expression

Haematologica, 2006
JAK2(V617F)an acquired mutation of JAK2, is present in a majority of patients with polycythemia vera and to a lesser extent among patients with the other myeloproliferative disorders.
Z Mnjoyan, D Yoon, J Li, F Delhommeau, V Afshar-Kharghan   +4 more
doaj  

Research Progress on Mechanisms of JAK2 Mutations in Coagulation Factor Regulation and Thrombosis

Zhongliu Fangzhi Yanjiu
The JAK2 V617F mutation is a key molecular event in myeloproliferative neoplasms and is strongly associated with an increased risk of thrombosis. This review aims to summarize the underlying mechanisms, clinical manifestations, and management strategies ...
Hongning LI, Huimin ZHU, Yuan DU, Jinjin ZHANG, Zhiyong CHENG   +4 more
doaj   +1 more source

Influence of the JAK2 V617F mutation and inherited thrombophilia on the thrombotic risk among patients with essential thrombocythemia

Haematologica, 2009
It is uncertain whether the JAK2 V617F mutation increases the thrombotic risk in patients with essential thrombocythemia, and it is unknown whether inherited thrombophilia is an additive risk factor in mutated subjects.
Valerio De Stefano, Tommaso Za, Elena Rossi, Alessia Fiorini, Angela Ciminello, Claudia Luzzi, Patrizia Chiusolo, Simona Sica, Giuseppe Leone   +8 more
doaj   +1 more source

Is Janus kinase 2 (JAK2) -V617F Mutation High Among healthy Blood Donors And Those With Raised Hemoglobin?

, 2022
Observational scoping review and meta-analysis about JAK2-V617F Mutation Frequency (Prevalence) Among Blood Donors (Healthy And Those With Raised Hemoglobin): A Systematic Review And Meta ...
Nahla Khamis, Mansour Alsharif, Maha Badawi, Mada Alsharif   +3 more
core   +1 more source

ARMS assay for JAK2 V617F.

, 2013
Of tracks for each sample, bands in 229-bp suggested the existence of the wild type allele, while a mutant allele was indicated by the presence of a band in 279-bp. The 463-bp product served as a control of amplification. M, 2000 bp DNA ladder; 1, dd H2O
Zhiyuan Wu (114653), Weiwei Liu (341566), Jinhua Xu (324388), Hong Yuan (104486), Wei Zhang (405), Ming Guan (126815), Xinju Zhang (126809)   +6 more
core   +1 more source

Iron deficiency in JAK2 exon12 and JAK2-V617F mutated polycythemia vera [PDF]

Blood Cancer Journal, 2021
Dan Liu, Zefeng Xu, Peihong Zhang, Tiejun Qin, Bing Li, Shiqiang Qu, Lijuan Pan, Wenyu Cai, Jinqin Liu, Huijun Wang, Qi Sun, Xiujuan Sun, Meng Jiao, Qingyan Gao, Zhongxun Shi, Huijun Huang, Gang Huang, Robert Peter Gale, Zhijian Xiao   +18 more
openaire   +3 more sources

The incidence of the JAK2 V617F mutation in patients with idiopathic erythrocytosis

Haematologica, 2006
Sixty-three patients with erythrocytosis exhibiting a range of erythropoietin levels were screened for the JAK2 V617F mutation. One patient (1.6%) was found to have this mutation, and has remained stable for 9 years, suggesting that the JAK2 V617F ...
MJ Percy, FG Jones, AR Green, JT Reilly, MF McMullin   +4 more
doaj