Results 101 to 110 of about 577,308 (213)

Janus kinase 2 mutations in cases with BCR-ABL-negative chronic myeloproliferative disorders from Turkey

Avicenna Journal of Medicine, 2017
Objective: We aimed to investigate the frequency of Janus kinase 2 ( JAK2) mutations in cases with chronic myeloproliferative disorders (CMDs), and the relationship between the presence of JAK2 mutation and leukocytosis and splenomegaly, retrospectively.
Ismail Yildiz, Osman Yokuş, Habip Gedik
doaj   +1 more source

Familial Essential Thrombocythemia Associated with MPL W515L Mutation in Father and JAK2 V617F Mutation in Daughter [PDF]

, 2014
Familial essential thrombocythemia features the acquisition of somatic mutations and an evolution similar to the sporadic form of the disease. Here we report two patients—father and daughter—with essential thrombocythemia who displayed a heterogeneous ...
Adrian P. Trifa, Andrei Cucuianu, Radu A. Popp   +2 more
core   +1 more source

The JAK2 V617F mutation in retinal vein or artery occlusion

EXCLI journal, 2019
EXCLI Journal;Vol.
openaire   +3 more sources

Detection of the Janus kinase 2 V617F mutation using a locked nucleic-acid, real-time polymerase chain reaction assay

African Journal of Laboratory Medicine, 2018
The purpose of this study was to develop a real time polymerase chain reaction (PCR) assay for the detection of the JAK2 V617F mutation that could be used in diagnostic laboratories.
Tshiphiri Senamela, Marleen Kock, Piet Becker, Joachim J.C. Potgieter   +3 more
doaj   +1 more source

The bidirectional relationship between JAK2V617F allele burden and inflammation in polycythaemia vera: Insights from interferon and ruxolitinib therapy

HemaSphere, Volume 10, Issue 8, August 2026.
Tiziano Barbui, Paola Guglielmelli, Alessandro Maria Vannucchi   +2 more
wiley   +1 more source

The Pattern of Thrombosis in Patients with JAK2 V617F Mutation

Journal of Blood Disorders, 2023
Background: JAK2V617F mutation is recurrent in MPN and reported as a marker for occult MPN in patients with splanchnic vein thrombosis. Objective: To better estimate the pattern of arterial and venous thrombosis in a Lebanese series in order to define the potential risk and to evaluate the current treatment.
openaire   +1 more source

The study of Jak2 V617F mutation in polycythemia vera with zebrafish model

, 2008
The study of Jak2 V617F mutation in polycythemia vera with zebrafish ...
Yok-Lam Kwong (829219), Alice MS Cheung (19197580), Raymond Liang (352795), Alvin CH Ma (19197577), Alister Ward (13059717), Wing-Yan Au (89841), Anskar YH Leung (19197583)   +6 more
core  

A mutação JAK2 V617F e as síndromes mieloproliferativas JAK2 V617F mutation and the myeloproliferative disorders

Revista Brasileira de Hematologia e Hemoterapia, 2008
Síndromes mieloproliferativas (SMPs) são doenças hematopoéticas de origem clonal que apresentam amplificação de uma ou mais linhagens mielóides. Policitemia vera (PV), trombocitemia essencial (TE), mielofibrose idiopática (MF) e leucemia mielóide crônica (LMC) são consideradas SMPs clássicas e apresentam características clínicas e biológicas comuns. Ao
Bárbara C. R. Monte-Mór, Fernando F. Costa   +1 more
openaire   +1 more source

Activation of integrin signaling up-regulates pro-inflammatory cytokines in JAK2-V617F positive hematopoietic cells

Cell Communication and Signaling
Background The JAK2-V617F mutation is the most frequent driver mutation in a group of malignant hematopoietic disorders called myeloproliferative neoplasms (MPN).
Conny K. Baldauf, Corinna Fahldieck, Alexa Angenstein, Sönke Weinert, Mariam Hakobyan, Daniel B. Lipka, Tobias R. Haage, Vikas Bhuria, Martin Böttcher, Dimitrios Mougiakakos, Burkhart Schraven, Thomas Fischer   +11 more
doaj   +1 more source

Occurrence of the JAK2 V617F mutation in the WHO provisional entity: myelodysplastic/myeloproliferative disease, unclassifiable-refractory anemia with ringed sideroblasts associated with marked thrombocytosis

Haematologica, 2006
The JAK2/V617F mutation has been noted in essential thrombocytemia. We investigated 19 cases with refractory anemia with ringed sideroblasts (RARS), including three RARS with thrombocytosis (RARS-T). Only the RARS-T patients showed this mutation.
AF Remacha, JF Nomdedeu, G Puget, C Estivill, MP Sarda, C Canals, A Aventin   +6 more
doaj