Results 121 to 130 of about 577,308 (213)

Expression level and differential JAK2-V617F–binding of the adaptor protein Lnk regulates JAK2-mediated signals in myeloproliferative neoplasms

, 2010
Activating mutations in signaling molecules, such as JAK2-V617F, have been associated with myeloproliferative neoplasms (MPNs). Mice lacking the inhibitory adaptor protein Lnk display deregulation of thrombopoietin/thrombopoietin receptor signaling ...
Bruno Cassinat, Sylvie Chevret, Carole Tonetti, Claudine Roger, Nadine Varin-Blank, Jean-Jacques Kiladjian, Florence Cymbalista, Anabell Alvarado, Stéphane Giraudier, Marie-Caroline Le Bousse-Kerdilès, Elizabeth Mazoyer, Pierre Fenaux, Fanny Baran-Marszak, Stéphanie Harel, Laura Velazquez, Hajer Magdoud, Christophe Desterke   +16 more
core   +1 more source

Neutrophilia and the JAK2 V617F Mutation

Pathology & Oncology Research, 2017
Stephen E, Langabeer, Karl, Haslam
openaire   +2 more sources

Rescue balloon pulmonary angioplasty for worsening chronic thromboembolic pulmonary hypertension with essential thrombocythaemia and the JAK2-V617F mutation: a case report. [PDF]

Eur Heart J Case Rep, 2023
Tamura H, Hosokawa S, Yuba K, Kishi K.
europepmc   +1 more source

4G/5G polymorphism and plasma levels of plasminogen activator inhibitor-1 in essential thrombocythemia patients with driver mutational status

Thrombosis Journal
Essential thrombocythemia (ET) is a kind of myeloproliferative neoplasms. Thrombosis is one of the common symptoms, however, the incidence of thrombosis in ET with JAK2, CALR, MPL gene mutations varies greatly, and the underlying mechanism is unclear ...
Xueya Zhang, Xizhe Guo
doaj   +1 more source

Detection of JAK2 V617F mutation among donors with erythrocytosis

, 2018
Introduction: It is mandatory that every blood donor must have their haemoglobin (Hb) values measured before blood donation. High Hb may indicate an underlying hidden pathological condition.
Nur Elida Mohd Kamil
core  

Altered gene expression in myeloproliferative disorders correlates with activation of signaling by the V617F mutation of Jak2

, 2005
We identified 13 new gene expression markers that were elevated and one marker, ANKRD15, that was down-regulated in patients with polycythemia vera (PV).
CAZZOLA, MARIO, Buser AS, Cazzola M, Tiedt R, Kralovics R, Pietra D, Skoda RC, Tichelli A, Teo SS, PASSAMONTI, FRANCESCO, Brutsche M, Passamonti F   +11 more
core   +1 more source

The Constitutive Activation of Jak2-V617F Is Mediated by a π Stacking Mechanism Involving Phenylalanines 595 and 617

, 2016
Somatic mutations in the Jak2 allele that lead to constitutive kinase activation of the protein have been identified in human disease conditions such as the myeloproliferative neoplasms (MPNs).
Peter P. Sayeski (395099), Kavitha Gnanasambandan (2249416), Andrew Magis (227914)   +2 more
core   +1 more source

Detection of JAK2 V617F Mutation among Donors with Erythrocytosis / Siti Fatimah Mohamed Kamaruzzaman … [et al.] [PDF]

, 2018
Introduction: It is mandatory that every blood donor must have their haemoglobin (Hb) values measured before blood donation. High Hb may indicate an underlying hidden pathological condition.
Mohamed Kamaruzzaman, Siti Fatimah, Mohd Yusoff, Shafini, Mohd Noor, Noor Haslina, Hasan, Mohd Nazri, Abdullah, Wan Zaidah   +4 more
core  

Low-level somatic JAK2 V617F mutation in myelodysplastic/myeloproliferative neoplasm with ring sideroblasts, and thrombocytosis with co-mutated SF3B1 and CALR. [PDF]

Blood Res, 2022
Ji YS, Park SK, Jeon BR, Jang MA.
europepmc   +1 more source

Limited effects on JAK2 mutational status after pegylated interferon alpha-2b therapy in polycythemia vera and essential thrombocythemia

Haematologica, 2006
Twenty-five patients with myeloproliferative diseases were treated with pegylated interferon alpha-2b. Prior to therapy, 15/25 patients had a JAK2(V617F) mutation.
J Samuelsson, M Mutschler, G Birgegard, P Gram-Hansen, M Bjorkholm, HL Pahl   +5 more
doaj