Results 211 to 220 of about 126,141 (353)

JAK inhibitors in toxic epidermal necrolysis a new frontier in therapeutics. [PDF]

Ann Med Surg (Lond)
Zahra FT, Imtiaz A, Khan A, Fatima M.
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Salvage therapy with JAK inhibitors in refractory Takayasu arteritis: a multicentre experience. [PDF]

RMD Open
Mekinian A, Meneses S, Biard L, Dagna L, Novikov P, Salvarani C, Espitia O, Hernández-Rodríguez J, Sacre K, Lioger B, Dufrost V, Audemard-Verger A, Tomelleri A, Kuwana M, Mukuchyan V, Dellal A, Muratore F, Campochiaro C, Moiseev S, Cacoub P, Fain O, Saadoun D, French Takayasu network.   +22 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Oral JAK Inhibitors as a Promising Therapeutic Strategy for Refractory Rosacea: A Systematic Review and Meta-Analysis. [PDF]

J Cosmet Dermatol
Peng Y, Sun M, Chen J, Huang X, Zhang F.
europepmc   +1 more source

JAK Inhibitors in Rheumatology: Implications for Paediatric Syndromes? [PDF]

, 2018
Sean Kerrigan, Iain B. McInnes
openalex   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

The Emerging World of JAK Inhibitors

Nepal Journal of Dermatology, Venereology & Leprology
The Janus Kinase inhibitors are a new emerging class of small molecules. These target the Janus Kinase proteins located on the cell membrane. Janus Kinase proteins regulate the cellular transcription of several proteins and act as mediators in several ...
Shraddha Uprety
doaj  

A Potential Role for JAK Inhibitors in Refractory Photoaggravated Atopic Dermatitis. [PDF]

Photodermatol Photoimmunol Photomed
Warner-Levy J, Khoursheed L, Parkin D, Ayer J.   +3 more
europepmc   +1 more source

Use of JAK inhibitors in the management of myelofibrosis: a revision of the British Committee for Standards in Haematology Guidelines for Investigation and Management of Myelofibrosis 2012 [PDF]

, 2014
John T. Reilly, Mary Frances McMullin, Philip Beer, Nauman M. Butt, Eibhlin Conneally, Andrew Duncombe, Anthony R. Green, G. Mikhaeel, Maria Gilleece, Steven Knapper, Adam J. Mead, Ruben A. Mesa, Mallika Sekhar, Claire Harrison   +13 more
openalex   +1 more source