The JAK/STAT signaling pathway: from bench to clinic
Signal Transduction and Targeted Therapy, 2021 The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular processes, the JAK/STAT pathway constitutes a rapid membrane-to-nucleus ...
Xia Zhao, Xiaoyi Hu
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The Role of JAK/STAT Pathway in Fibrotic Diseases: Molecular and Cellular Mechanisms
Biomolecules, 2023 There are four members of the JAK family and seven of the STAT family in mammals. The JAK/STAT molecular pathway could be activated by broad hormones, cytokines, growth factors, and more.
Fengming Luo, Jia Liu, Faping Wang
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Natural products for the treatment of ulcerative colitis: focus on the JAK/STAT pathway [PDF]
Frontiers in ImmunologyUlcerative colitis (UC) is an autoimmune disease with an incompletely understood pathogenesis. The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway plays a key role in immune response and inflammation. More and
Dan Long +4 more
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Pharmacological Effects of Polyphenol Phytochemicals on the JAK-STAT Signaling Pathway
Frontiers in Pharmacology, 2021 The JAK-STAT signaling pathway is a common pathway of many cytokine signal transductions, closely related to cell proliferation, apoptosis, differentiation, and inflammatory response.
Daquan Chen, Wenwei Zhu
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microRNA-34 mediates a negative feedback loop in the JAK-STAT pathway to attenuate immune overactivation in an invertebrate [PDF]
Cell Communication and SignalingThe JAK-STAT pathway is an essential signaling mechanism that initiates immune responses against pathogen infections. The intrinsic homeostatic regulation of JAK-STAT signaling is critical for maintaining immune homeostasis.
Hongliang Zuo +7 more
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Viral Mechanisms and Drug Influences on Janus Kinase/Signal Transducers and Activators of Transcription (JAK/STAT) Pathway in Human Coronaviruses Infection: A Systematic Review [PDF]
Health Science ReportsBackground and Aim Janus kinases/signal transducers and activators of transcription (JAK/STAT) pathway is crucial for various stages of immunity, from innate to adaptive responses.
Esimebia Adjovi Amegashie +7 more
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Targeting CXCL8 alleviates intestinal epithelial inflammation by suppressing the JAK-STAT pathway [PDF]
European Journal of Medical ResearchBackground Inhibition of CXCL8 has been shown to alleviate small intestinal inflammation and suppress activation of Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling pathway.
Xiaolong Wu +6 more
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Modulating the JAK/STAT pathway with natural products: potential and challenges in cancer therapy [PDF]
Discover OncologyThe Janus Kinase/Signal Transducer and Activator of Transcription (JAK/STAT) pathway is a critical signaling network governing cellular functions such as immune responses, proliferation, and apoptosis. Dysregulation of this pathway is strongly implicated
Bhagyalakshmi Nair +5 more
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Frontiers in Immunology, 2021 JAK/STAT signaling regulates central biological functions such as development, cell differentiation and immune responses. In Drosophila, misregulated JAK/STAT signaling in blood cells (hemocytes) induces their aberrant activation. Using mass spectrometry
Mirva Järvelä-Stölting +8 more
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The role of janus kinases in the treatment of autoimmune skin diseases [PDF]
Farmacja Polska, 2021 The JAK / STAT signaling pathway is a pleiotropic signal transduction pathway for many biochemical substances that are ligands, for example cytokines, growth factor, leptin, erythropoietin or interferons.
Arnold Kukowka +3 more
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