Results 21 to 30 of about 1,601,122 (283)

The JAK-STAT Pathway at Twenty [PDF]

Immunity, 2012
We look back on the discoveries that the tyrosine kinases TYK2 and JAK1 and the transcription factors STAT1, STAT2, and IRF9 are required for the cellular response to type I interferons. This initial description of the JAK-STAT pathway led quickly to additional discoveries that type II interferons and many other cytokines signal through similar ...
Stark, George R., Darnell, James E.
openaire   +2 more sources

JAK/STAT pathway: Extracellular signals, diseases, immunity, and therapeutic regimens

Frontiers in Bioengineering and Biotechnology, 2023
Janus kinase/signal transduction and transcription activation (JAK/STAT) pathways were originally thought to be intracellular signaling pathways that mediate cytokine signals in mammals.
Qian Hu, Qian Hu, Qian Hu, Qian Hu, Qihui Bian, Dingchao Rong, Leiyun Wang, Leiyun Wang, Leiyun Wang, Jianan Song, Hsuan-Shun Huang, Jun Zeng, Jie Mei, Jie Mei, Jie Mei, Peng-Yuan Wang   +15 more
doaj   +1 more source

Cytokines Activate JAK–STAT Signaling Pathway in MG-63 Cells on Titanium and Zirconia [PDF]

, 2022
Although titanium has been traditionally used as the gold standard for dental implants, recent years have seen the widespread application of zirconia implants given their superiority with regards to reduced bacterial adhesion, inflammation and cellular ...
Khaled Mukaddam, Kühl, Sebastian, Ruggiero, Sabrina, Berger, Steffen M., Bornstein, Michael M, Sebastian Kühl, Mukaddam, Khaled, Alhawasli, Farah, Payer, Michael, Farah Alhawasli, Elizaveta Fasler-Kan, Vegh, Daniel, Daniel Vegh, Cholewa, Dietmar, Sabrina Ruggiero, Fasler-Kan, Elizaveta, Dietmar Cholewa, Michael M. Bornstein, Berger, Steffen M, Steffen M. Berger, Michael Payer, Bornstein, Michael M.   +21 more
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TheDrosophilaJAK-STAT pathway [PDF]

JAK-STAT, 2013
The conservation of signaling cascades between humans and Drosophila, over more than 500 million years of evolutionary time, means that the genetic tractability of the fly can be used to its full advantage to understand the functional requirements for JAK-STAT pathway signaling across species.
Zeidler, Martin P, Bausek, Nina
openaire   +2 more sources

JAK-STAT in Early Hematopoiesis and Leukemia

Frontiers in Cell and Developmental Biology, 2021
Hematopoietic stem cells (HSCs) produce all the terminally differentiated blood cells and are controlled by extracellular signals from the microenvironment, the bone marrow (BM) niche, as well as intrinsic cell signals.
Eirini Sofia Fasouli, Eleni Katsantoni
doaj   +1 more source

The JAK-STAT pathway promotes persistent viral infection by activating apoptosis in insect vectors.

PLoS Pathogens, 2023
The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway is an evolutionarily conserved signaling pathway that can regulate various biological processes.
Yan Zhang, Bo-Xue Li, Qian-Zhuo Mao, Ji-Chong Zhuo, Hai-Jian Huang, Jia-Bao Lu, Chuan-Xi Zhang, Jun-Min Li, Jian-Ping Chen, Gang Lu   +9 more
doaj   +1 more source

JAK and STAT gene mutations and JAK-STAT pathway activation in lympho- and myeloproliferative neoplasms [PDF]

, 2022
Lympho- and myeloproliferative neoplasms are a very heterogeneous group of haematological malignancies originating from a haematopoietic stem cell (HSC).
Andrzejewska, Dominika; Department of Hematology and Bone Mar row Transplantation, Medical Faculty, Poznan University of Medical Sciences, Poznan, Poland, Gulaczyk, Hanna; Department of Hematology and Bone Mar row Transplantation, Medical Faculty, Poznan University of Medical Sciences, Poznan, Poland, Kuczyńska, Martyna; Department of Hematology and Bone Mar row Transplantation, Medical Faculty, Poznan University of Medical Sciences, Poznan, Poland, Łączak, Michał; Department of Hematology and Bone Mar row Transplantation, Medical Faculty, Poznan University of Medical Sciences, Poznan, Poland, Grochowska, Wiktoria; Department of Hematology and Bone Mar row Transplantation, Medical Faculty, Poznan University of Medical Sciences, Poznan, Poland, Grygier, Joanna; Department of Hematology and Bone Mar row Transplantation, Medical Faculty, Poznan University of Medical Sciences, Poznan, Poland, Lewandowski, Krzysztof; Department of Hematology and Bone Mar row Transplantation, Medical Faculty, Poznan University of Medical Sciences, Poznan, Poland   +6 more
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Quercetin as a JAK–STAT inhibitor: a potential role in solid tumors and neurodegenerative diseases

Cellular & Molecular Biology Letters, 2022
The Janus kinase–signal transducer and activator of transcription (JAK–STAT) pathway is involved in many immunological processes, including cell growth, proliferation, differentiation, apoptosis, and inflammatory responses.
Hamidreza Zalpoor, Mohsen Nabi-Afjadi, Razieh Forghaniesfidvajani, Chanour Tavakol, Faranak Farahighasreaboonasr, Farid Pakizeh, Vahid Ghobadi Dana, Farhad Seif   +7 more
doaj   +1 more source

The JAK/STAT Pathway [PDF]

Cold Spring Harbor Perspectives in Biology, 2012
The Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling pathway mediates cellular responses to cytokines (e.g., IL-6) and growth factors (e.g., EGF).
openaire   +2 more sources

Modulation of human JAK-STAT pathway signaling by functionally conserved regulators [PDF]

, 2014
Both the core JAK-STAT pathway components and their in vivo roles have been widely conserved between vertebrates and invertebrate models such as Drosophila melanogaster.
Müller, Patrick, Zeidler, Martin P., Pugazhendhi, Dhamayanthi   +2 more
core   +1 more source