Results 11 to 20 of about 1,601,122 (283)
JAK-STAT pathway inhibitors in dermatology [PDF]
Anais Brasileiros de Dermatologia, 2023 The JAK-STAT signaling pathway mediates important cellular processes such as immune response, carcinogenesis, cell differentiation, division and death. Therefore, drugs that interfere with different JAK-STAT signaling patterns have potential indications ...
Hélio Amante Miot +5 more
doaj +4 more sources
The JAK/STAT Pathway in Skeletal Muscle Pathophysiology [PDF]
Frontiers in Physiology, 2019 The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is a key intracellular mediator of a variety of metabolically relevant hormones and cytokines, including the interleukin-6 (IL-6) family of cytokines.
Viviana Moresi +5 more
doaj +6 more sources
Evolution of the JAK-STAT pathway [PDF]
JAK-STAT, 2013 The JAK-STAT pathway represents a finely tuned orchestra capable of rapidly facilitating an exquisite symphony of responses from a complex array of extracellular signals.
Clifford Liongue (13064595) +1 more
core +3 more sources
Methotrexate Is a JAK/STAT Pathway Inhibitor [PDF]
PLOS ONE, 2015 Background: The JAK/STAT pathway transduces signals from multiple cytokines and controls haematopoiesis, immunity and inflammation. In addition, pathological activation is seen in multiple malignancies including the myeloproliferative neoplasms (MPNs ...
Martin P Zeidler +17 more
core +7 more sources
Research Advances of JAK/STAT Signaling Pathway in Lung Cancer
Chinese Journal of Lung Cancer, 2019 Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway is one of the downstream pathways of cytokine signaling transduction. It regulates cell development, differentiation, proliferation, apoptosis and so on.
Xin YANG, Zhe TANG, Peng ZHANG, Li ZHANG
doaj +2 more sources
Parameter inference in mechanistic models of cellular regulation and signalling pathways using gradient matching [PDF]
, 2012 A challenging problem in systems biology is parameter inference in mechanistic models of signalling pathways. In the present article, we investigate an approach based on gradient matching and nonparametric Bayesian modelling with Gaussian processes.
Dondelinger, F. +7 more
core +9 more sources
JAK-STAT Signalling Pathway in Cancer [PDF]
Cancers, 2020 n ...
Andrew J. Brooks, Tracy Putoczki
openaire +5 more sources
Frontiers in Immunology, 2022 The JAK/STAT pathway plays an important role in the development and immune responses of animals. In vertebrates, families of cytokines or growth factors act as activators of the JAK/STAT pathway; however, the activators for the JAK/STAT signaling pathway
Xiao-qin Ran +3 more
doaj +1 more source
The JAK/STAT signaling pathway [PDF]
Journal of Cell Science, 2004 The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies.
Jason S, Rawlings +2 more
openaire +2 more sources
Evolving cognition of the JAK-STAT signaling pathway: autoimmune disorders and cancer
Signal Transduction and Targeted Therapy, 2023 The Janus kinase (JAK) signal transducer and activator of transcription (JAK-STAT) pathway is an evolutionarily conserved mechanism of transmembrane signal transduction that enables cells to communicate with the exterior environment.
Chen Xue +8 more
doaj +1 more source