Results 31 to 40 of about 1,601,122 (283)
Frontiers in Immunology, 2017 Interferons (IFNs), which were discovered a half century ago, are a group of secreted proteins that play key roles in innate immunity against viral infection.
Yuchen Nan +3 more
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Molecular dissection of Janus kinases as drug targets for inflammatory diseases
Frontiers in Immunology, 2022 The Janus kinase (JAK) family enzymes are non-receptor tyrosine kinases that phosphorylate cytokine receptors and signal transducer and activator of transcription (STAT) proteins in the JAK-STAT signaling pathway.
Sunghark Kwon
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Windpipe controls Drosophila intestinal homeostasis by regulating JAK/STAT pathway via promoting receptor endocytosis and lysosomal degradation. [PDF]
PLoS Genetics, 2015 The adult intestinal homeostasis is tightly controlled by proper proliferation and differentiation of intestinal stem cells. The JAK/STAT (Janus Kinase/Signal Transducer and Activator of Transcription) signaling pathway is essential for the regulation of
Wenyan Ren +8 more
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The potential roles of JAK/STAT signaling in the progression of osteoarthritis
Frontiers in Endocrinology, 2022 Osteoarthritis (OA) is an age-related chronic progressive degenerative disease that induces persistent pain and disabilities. The development of OA is a complex process, and the risk factors are various, including aging, genetics, trauma and altered ...
Qingluo Zhou +8 more
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The JAK-STAT pathway at 20 [PDF]
JAK-STAT, 2012 On September 22–24, 2011 a group of over 150 scientists convened at the National Institutes of Health in Bethesda, Maryland to celebrate the 20th anniversary of the definitive molecular studies that revealed the JAK-STAT pathway. Organized chiefly by John O’Shea with a big assist from Richard Jove and minor assists from David Levy, myself and others,
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Molecular Medicine, 2019 Background Since its discovery almost three decades ago, the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway has paved the road for understanding inflammatory and immunity processes related to a wide range of human ...
Wai Hoong Chang, Alvina G. Lai
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The roles of the Drosophila JAK/STAT pathway [PDF]
Oncogene, 2000 The JAK/STAT signal transduction pathway has been conserved throughout evolution such that true structural and functional homologues of components originally identified in vertebrate systems are also present in the model genetic system Drosophila melanogaster.
M P, Zeidler, E A, Bach, N, Perrimon
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Targeting JAK/STAT pathway in Takayasu's arteritis [PDF]
Annals of the Rheumatic Diseases, 2020 Takayasu's arteritis (TAK) is a large vessel vasculitis with important infiltration of proinflammatory T cells in the aorta and its main branches, but its aetiology is still unknown. Our work aims to explore the involvement of Janus Kinase/Signal Transducers and Activators of Transcription (JAK/STAT) signalling pathway in proinflammatory T cells ...
Régnier, Paul +8 more
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, 2022 Preventing development of childhood B-cell acute lymphoblastic leukemia (B-ALL), a disease with devastating effects, is a longstanding and unsolved challenge.
Isidro-Hernández, Marta +24 more
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Inteferons pen the JAK–STAT pathway [PDF]
Seminars in Cell & Developmental Biology, 2008 Characterization of how interferons (IFNs) mediate their biological response led to identification of the JAK-STAT signaling cascade, where JAKs are receptor-associated kinases and STATs the transcription factors they activate. Today, 4 JAKs and 7 STATs are known to transduce pivotal signals for the over 50 members of the four-helix bundle family of ...
Christian, Schindler, Courtney, Plumlee
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