Results 41 to 50 of about 1,601,122 (283)

Role of the JAK/STAT Pathway in Cervical Cancer: Its Relationship with HPV E6/E7 Oncoproteins

Cells, 2020
The janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway is associated with the regulation of essential cellular mechanisms, such as proliferation, invasion, survival, inflammation, and immunity.
Adriana Gutiérrez-Hoya, Isabel Soto-Cruz   +1 more
doaj   +1 more source

Targeting the immune microenvironment during immunotherapy for solid tumors

Molecular & Cellular Oncology, 2021
JAK/STAT signaling is a central hub in cancer development, progression, immunosurveillance and response to immunotherapy. We discuss recent advances in the role of the JAK/STAT pathway in immunotherapies.
Aiman Sabaawy, Saman Zeeshan
doaj   +1 more source

Arsenic inhibition of the JAK-STAT pathway [PDF]

Oncogene, 2004
The Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway is an essential cascade for mediating normal functions of different cytokines in the development of the hematopoietic and immune systems. Chronic exposure to arsenic has been found to cause immunotoxicity and has been associated with the suppression of hematopoiesis (
Haiyun Y, Cheng, Ping, Li, Michael, David, Thomas E, Smithgall, Lili, Feng, Michael W, Lieberman   +5 more
openaire   +2 more sources

Lyophilized MSC-EVs attenuates COVID-19 pathogenesis by regulating the JAK/STAT pathway. [PDF]

Stem Cell Res Ther
Background: The JAK/STAT signaling pathway plays a crucial role in the release of interferons (IFNs) and the proinflammatory response during SARS-CoV-2 infection, contributing to the cytokine storm characteristic of severe COVID-19 cases.
Ebrahim N, Al Saihati HA, Alali Z, Mahmoud SYM, Rabaan AA, Dessouky AA, Salim RF, Shamaa AA, Abdallah AN, Elsherbiny NM, Othman G, Badawy AA, Di Leva G, Badr OA.   +13 more
europepmc   +2 more sources

JAK-STAT and bone metabolism

, 2013
Emerging evidences suggest Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling pathway plays an important role in bone development and metabolism.
Li, Jiliang
core   +1 more source

JAK-STAT pathway and myogenic differentiation [PDF]

JAK-STAT, 2013
Myogenic differentiation plays an important role in muscle regeneration and is regulated by two transcription factor families, MRFs and MEF2, which induce differentiation of myoblasts through expression of the muscle-specific gene, myogenin. In addition, many intracellular signaling pathways are also involved in myogenic differentiation, including p38 ...
Jang, You-Na, Baik, Eun Joo
openaire   +2 more sources

1H NMR Study on Serum Metabonomic Alterations Induced by JAK/STAT Pathway Inhibitor in C57BL/6 Mice

Chinese Journal of Magnetic Resonance, 2018
JAK/STAT pathway inhibitor has been used in clinic trial for several diseases. However, the adverse effect of systematic administration of JAK/STAT pathway inhibitors on cellular function is largely unknown.
ZHAO Xin, XIAO Xiong-jie, GAO Dong-li, ZHANG Xian-rong   +3 more
doaj   +1 more source

E-cadherin acts as a positive regulator of the JAK-STAT signaling pathway during Drosophila oogenesis

Frontiers in Cell and Developmental Biology, 2022
The JAK-STAT pathway is evolutionary conserved. The simplicity of this signaling in Drosophila, due to the limited redundancy between pathway components, makes it an ideal model for investigation.
Charlotte Mallart, Fabienne Chalvet, Sophie Netter, Alba Yurani Torres, Mickael Poidevin, Jacques Montagne, Anne-Marie Pret, Marianne Malartre   +7 more
doaj   +1 more source

Systematic Review: JAK-STAT Regulation and Its Impact on Inflammation Response in ARDS from COVID-19

Immuno
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has had a global impact and resulted in millions of deaths worldwide. The course of the Janus kinase signaling transducers and activators (JAK-STAT) pathway is an important molecular ...
Irasema Rodriguez, Kate J. F. Carnevale
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source