Results 51 to 60 of about 1,601,122 (283)

Interferon functional analog activates antiviral Jak/Stat signaling through integrin in an arthropod

Cell Reports, 2021
Summary: Drosophila Vago is a small antiviral peptide. Its ortholog in Culex mosquito was found to be an interferon-like cytokine that limits virus replication through activating Jak/Stat signaling.
Jie Gao, Bao-Rui Zhao, Hui Zhang, Yan-Lin You, Fang Li, Xian-Wei Wang   +5 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Basics of Janus kinases: a review

Journal of the Egyptian Women’s Dermatologic Society, 2020
Janus kinases (JAKs) are a group of nonreceptor intracellular tyrosine kinases that could modify cytokine-mediated signals through the JAK-signal transducer and activator of transcription (STAT) pathway. The intracellular signaling pathway JAK/STAT has a
Hanan R Nada, Maha F Elmasry, Dina A El Sharkawy, Sally Mamdouh   +3 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

The JAK/STAT Pathway Is Involved in Synaptic Plasticity [PDF]

, 2012
SummaryThe Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is involved in many cellular processes, including cell growth and differentiation, immune functions and cancer.
Choi, S-L, Lee, Kyungmin, Peineau, Stéphane, Nicolas, Céline S, Nicolas, Céline S., Bortolotto, Zuner A, Lee, K, Kaang, Bong-Kiun, Sim, Su-Eon, Amici, Mascia, Seaton, Gillian, Nicolas, C, Choi, Sun-Lim, Seaton, G, Collett, Valerie J, Cho, K, Collett, VJ, Bortolotto, ZA, Collett, Valerie J., Csaba, Zsolt, Cho, Kwangwook, Kaang, B-K, Fitzjohn, Stephen M., Bradley, Clarrisa, Hildebrandt, Lars, Gressens, P, Dournaud, P, Fafouri, Assia, Csaba, Z, Fitzjohn, Stephen M, Dournaud, Pascal, Fafouri, A, Javalet, C, Javalet, Charlotte, Sim, S-E, Gressens, Pierre, Collingridge, GL, Peineau, SAJ, Collingridge, Graham L, Collingridge, Graham L., Amici, M, Bortolotto, Zuner A., Zhuo, M, Zhuo, Min, Bradley, C, Hildebrandt, L   +45 more
core   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Inhibition of JAK-STAT Signaling Pathway Alleviates Age-Related Phenotypes in Tendon Stem/Progenitor Cells

Frontiers in Cell and Developmental Biology, 2021
Diminished regeneration or healing capacity of tendon occurs during aging. It has been well demonstrated that tendon stem/progenitor cells (TSPCs) play a vital role in tendon maintenance and repair.
Minhao Chen, Minhao Chen, Minhao Chen, Longfei Xiao, Longfei Xiao, Longfei Xiao, Guangchun Dai, Guangchun Dai, Guangchun Dai, Panpan Lu, Panpan Lu, Panpan Lu, Yuanwei Zhang, Yuanwei Zhang, Yuanwei Zhang, Yingjuan Li, Ming Ni, Yunfeng Rui, Yunfeng Rui, Yunfeng Rui, Yunfeng Rui   +20 more
doaj   +1 more source

Characterisation of Upd2, a Drosophila JAK/STAT pathway ligand [PDF]

, 2005
14 páginas, 8 figuras, 1 tabla.The characterisation of ligands that activate the JAK/STAT pathway has the potential to throw light onto a comparatively poorly understood aspect of this important signal transduction cascade. Here, we describe our analysis
Zeidler, Martin P., Castelli-Gair Hombría, James, Brown, Stephen, Brown, S., Haeder, S., Zeidler, M., Hombría, James Castelli Gair, Hombria, J. C. G., Zeidler, M. P., Häder, Sabine, Hombría, James Castelli-Gair, Hombria, J.   +11 more
core   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source