Results 221 to 230 of about 126,141 (353)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Review of Herpes Zoster Occurrence in Patients With Atopic Dermatitis Treated With JAK Inhibitors. [PDF]

Clin Transl Sci
Mandecka A, Perlak K, Bajek W, Kruczek W, Frątczak A, Polak K, Miziołek B, Bergler-Czop B.   +7 more
europepmc   +1 more source

The role of Janus kinase signaling in graft-versus-host disease and graft versus leukemia [PDF]

, 2018
Choi, Jaebok, DiPersio, John F, Schroeder, Mark A, Staser, Karl   +3 more
core   +2 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Comparison of the enzymatic and cellular profiles of clinical JAK inhibitors for the treatment of myelofibrosis. [PDF]

Blood Neoplasia
Celik H, Wass B, Zolotarjova N, Trivedi G, Margulis A, Drake K, Covington M, Laranjeira ABA, Katiyar K, Smith A, Zhang G, Macarrón R.   +11 more
europepmc   +1 more source

The transmembrane domain of the ASFV p22 is essential for inhibiting the activation of the JAK-STAT signaling pathway.

Haojie Ren (9353596), Yanjin Wang (1375503), Lian-Feng Li (14680123), Lan-Fang Shi (21728677), Yu-He Ma (21728680), Jun-Hao Fan (21728683), Xiao-Ya Pan (21728686), Han-Cheng Shao (21728689), Yuhang Zhang (3144870), Shichong Han (665820), Bo Wan (212083), Hua-Ji Qiu (3967025), Gai-Ping Zhang (8616999), Su Li (294188), Wen-Rui He (21728692)   +14 more
openalex   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

From apremilast to JAK inhibitors-salvage treatment strategies for refractory palmoplantar pustulosis: case series. [PDF]

Front Med (Lausanne)
Pan Y, Jin D, Meng F, Zhang H, Tang J, Guo C, Li C, Ma J.   +7 more
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Mastering the Use of Systemic JAK Inhibitors for Atopic Dermatitis: A Dermatologist's Practical Guide. [PDF]

Am J Clin Dermatol
Jalili A, Labbouz S, Gooderham M, Ziv M, Dodiuk-Gad RP.   +4 more
europepmc   +1 more source