Results 241 to 250 of about 126,141 (353)

Efficacy of Tapering Biologics and JAK Inhibitors in Rheumatoid Arthritis: A Systematic Review and Meta-analysis [PDF]

Sandra Rotea-Salvo, Laura Galindo-Dominguez, Belén Vera, Vanesa Balboa‐Barreiro, Luis Ramudo, Maite Silva-Díaz, N. Oreiro-Villar, Francisco Javier de Toro Santos, Isabel Martín‐Herranz, Francisco J. Blanco   +9 more
openalex   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

From concept to practice: real-world safety of JAK inhibitors in rheumatoid arthritis treatment. [PDF]

Front Med (Lausanne)
Bonfiglioli KR.
europepmc   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

JAK inhibitors for the treatment of palmoplantar pustulosis: a narrative review. [PDF]

Drugs Context
Henriques Dos Santos B, Domingues J, Sousa M, Torres T.   +3 more
europepmc   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

JAK inhibitors in autoimmune ocular inflammatory diseases - A systematic review of case reports and series. [PDF]

J Ophthalmic Inflamm Infect
Almerri S, Alshatti H, Ali YT, Behbehani R.   +3 more
europepmc   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Application of JAK inhibitors in the treatment of rheumatoid arthritis: a systematic analysis based on clinical trial databases and registries. [PDF]

Front Med (Lausanne)
Cao J, Huang R, Chen Y, Li X, Lou J, Xu L, Gu J, Luo Z, Yao T, Xie J.   +9 more
europepmc   +1 more source

Targeting the STAT5 pathway in Ph+ acute lymphoblastic leukemia [PDF]

, 2018
Calabretta, Bruno, De Dominici, Marco, Minieri, Valentina, Nevalainen, Marja T.   +3 more
core   +2 more sources