Results 101 to 110 of about 199,620 (187)

Improving the Hydraulic and Chemical Properties of Sandy Soil by Using a Mixture of Biochar and Clay

iRASD Journal of Energy & Environment
In recent years, food demand has risen due to rapid population surge. Meeting this food demand means more land is supposed to be cultivated. Yet, there are many areas in Sindh, Pakistan, particularly “Thar,” where crop yield is inadequate due to the ...
Lareb Bhirai, Mahmood Laghari, Hafeez-Ur- Rehman, Rajesh Kumar   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

[News Clip: Traffic jam]

, 1958
Video footage from the WBAP-TV station in Fort Worth, Texas to accompany a news story about a large traffic jam in ...
WBAP-TV (Television station : Fort Worth, Tex.)
core  

Effect of selenium application methods on growth, water productivity and essential oil of peppermint (Mentha piperata L.) under drought stress

BMC Plant Biology
Background Selenium (Se) is one of the beneficial elements for plants and can enhance the antioxidant capacity and tolerance of plants against the adverse effects of drought stress.
Vahid Shamsabadi, Hamid Reza Roosta, Mahdi Moradi, Mohammadnaser Modoodi   +3 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

JAM-C is ubiquitylated, and this governs its targeting to MVBs.

, 2019
(A) A schematic representation of the JAM-C–EGFPout construct showing all the lysine residues in the cytoplasmic tail that can be potentially modified by ubiquitylation and the JAM-C mutant generated.
Vinothini Rajeeve (4257748), Christopher Schultz (1285389), Tom P. Mitchell (8067533), Katja B. Kostelnik (8067530), Michel Aurrand-Lions (38691), Amy Barker (132438), Ian J. White (8067536), Pedro Cutillas (5704640), Thomas D. Nightingale (8067539), Sussan Nourshargh (157725)   +9 more
core   +1 more source

Effectiveness of Cognitive-behavioral Therapy on the Psychological Security and Self-care Behaviors among Diabetes Patients [PDF]

Practice in Clinical Psychology
Objective: Type 2 diabetes mellitus (T2DM) is a chronic disease that increases the possibility of mental disorders due to physical problems. Therefore, psychological interventions such as diabetes self-care activities (DSCA) can probably create positive ...
Sima Farimanian, Mohammad Hossein Bayazi
doaj  

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source