Results 81 to 90 of about 199,620 (187)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
JAM-A expression positively correlates with poor prognosis in breast cancer patients.
, 2009 The cell-cell adhesion protein junctional adhesion molecule-A (JAM-A) influences epithelial cell morphology and migration. As migration is required for tumor cell invasion and metastasis, we sought to elucidate the role of JAM-A in invasive breast cancer.
Sharon F. McGee (7957613) +8 more
core +2 more sources
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
EXAMINATION OF ICE JAM CONSIDERING THE EFFECT OF BACK WATER IN THE KENUFUCHI RIVER [PDF]
, 2020 On March 9, 2018, an ice jam occurred on the Kenefuchi River a tributary of Chitose river, due to rainfall and rising temperatures. The Kenefuchi River is narrow and has several bridges, etc., making it more vulnerable to ice jam.
横山, 洋 +8 more
core
, 2022 Menara jam yang hari ini dikenal sebagai landmark kota Bukittinggi ini adalah hadiah dari Ratu Wilhelmina untuk sekretaris Fort De Kock pada masa kolonial Belanda.
Parlindungan Siregar
core +1 more source
Evaluation of Yield and Some Root and Morphological Characteristics Response of Guar (Cyamopsis tetragonoloba L.) in Intercropping with Roselle (Hibiscus sabdariffa L.) under Nitrogen Fertilizer Management [PDF]
بوم شناسی کشاورزیIntroductionGuar (Cyamopsis tetragonoloba L.) is an annual plant that tolerates salinity and drought from the legume family, which can be used as an alternative product in low-water plains. Considering the characteristics of the guar, such as having the
Mohammadnaser Modoodi +2 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
FIELD SURVEY OF ICE JAM IN MARCH 2020 AND EVALUATION OF ICE JAM OCCURANCE RISK [PDF]
, 2020 結氷河川の解氷期に発生するアイスジャムは，水位の急上昇や流下河氷への巻き込まれ事故などを引き起こすこともあり，結氷河川の維持管理上の課題の１つとなっている．アイスジャムによる被害軽減策として，実用的なアイスジャム発生予測技術の開発があるが，現地適用に向けて近年の現地事例を収集することおよびモデル適用の課題と解決を進めることが重要である．本研究ではまず2020年3月に北海道内の複数河川で発生したアイスジャムの発生機構を整理し，河川監視カメラによる河道内画像と水位変動により発生時期把握が可能なことを確認した．
横山, 洋 +8 more
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