Results 91 to 100 of about 199,620 (187)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Comparing the Effectiveness of Acceptance and Commitment Therapy With Compassion-Focused Therapy on the Intensity of Resiliency and Worry in Patients With Multiple Sclerosis

Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk, 2022
Background and Aim Given the increasing number of patients with multiple sclerosis and the psychological complications that affect this group, the present study was conducted to compare the effectiveness of acceptance and commitment therapy and ...
Pardis MirMoeini, Mohammad Hosseini Bayazi, Javad Khlatbari   +2 more
doaj  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

JAM-C is internalised from junctions near the front of migrating cells.

, 2019
(A) JAM-C–GFPout was expressed in HUVECs, and the cells were allowed to form a confluent monolayer. The cell layer was scratched, and 45 min later, live-cell imaging was carried out with images acquired every 30 s for 45 min.
Vinothini Rajeeve (4257748), Christopher Schultz (1285389), Tom P. Mitchell (8067533), Katja B. Kostelnik (8067530), Michel Aurrand-Lions (38691), Amy Barker (132438), Ian J. White (8067536), Pedro Cutillas (5704640), Thomas D. Nightingale (8067539), Sussan Nourshargh (157725)   +9 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

A comparative study of mindfulness-based cognitive therapy and emotion-focused therapy in reducing experiential avoidance in patients with peptic ulcer disease

مجله علوم پزشکی فیض (پیوسته)
Background and Aim: Peptic ulcer disease, as a psychosomatic disorder, is closely related to avoidance mechanisms and stress. This study aimed to compare the effectiveness of group-based mindfulness-based cognitive therapy (MBCT) and emotion-focused ...
Fatemeh Amanloo, Mohammad Rajabi, Mahhdi Nayyeri   +2 more
doaj  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Sputnik Ware Jam Pot

, 2010
Jam pot, turquoise with black spots. with hinged lid and handle to one side. Transparent inner container. Date: 1959 - from the The Betty Smithers Design Collection at Staffordshire University.
The Betty Smithers Design Collection at Staffordshire University, Staffordshire University   +1 more
core  

The effect of cognitive-behavioral group training of self-care skills on positive and negative signs and general psychopathology symptoms in patients with schizophrenia in patients with schizophrenia

دانش و پژوهش در روان‌شناسی کاربردی
The aim of this study was to determine the effect of cognitive-behavioral group training of self-care skills on positive and negative signs, and general psychopathology of patients with schizophrenia.
Masoud Kashani Lotfabadi, Mohammad Hossein Bayazi, Ali Reza Rajaei   +2 more
doaj