Results 111 to 120 of about 1,320,130 (285)

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Corrigendum

Jurnal Aplikasi Manajemen
Corrigendum to “The Role of Women Merchants in Increasing Family’s Income (A Case Study on Indigenous Papuan Women Merchants)“ [JAM: Jurnal Aplikasi Manajemen, 14(4), 641-649]
JAM JAM
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Improving the Hydraulic and Chemical Properties of Sandy Soil by Using a Mixture of Biochar and Clay

iRASD Journal of Energy & Environment
In recent years, food demand has risen due to rapid population surge. Meeting this food demand means more land is supposed to be cultivated. Yet, there are many areas in Sindh, Pakistan, particularly “Thar,” where crop yield is inadequate due to the ...
Lareb Bhirai, Mahmood Laghari, Hafeez-Ur- Rehman, Rajesh Kumar   +3 more
doaj   +1 more source

Evaluation of Yield and Some Root and Morphological Characteristics Response of Guar (Cyamopsis tetragonoloba L.) in Intercropping with Roselle (Hibiscus sabdariffa L.) under Nitrogen Fertilizer Management [PDF]

بوم شناسی کشاورزی
IntroductionGuar (Cyamopsis tetragonoloba L.)  is an annual plant that tolerates salinity and drought from the legume family, which can be used as an alternative product in low-water plains. Considering the characteristics of the guar, such as having the
Mohammadnaser Modoodi, Vahid Shamsabadi, Ebrahim Jahangir Dehborzoui   +2 more
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Comparing the Effectiveness of Acceptance and Commitment Therapy With Compassion-Focused Therapy on the Intensity of Resiliency and Worry in Patients With Multiple Sclerosis

Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk, 2022
Background and Aim Given the increasing number of patients with multiple sclerosis and the psychological complications that affect this group, the present study was conducted to compare the effectiveness of acceptance and commitment therapy and ...
Pardis MirMoeini, Mohammad Hosseini Bayazi, Javad Khlatbari   +2 more
doaj  

Assessing the aridity indices in Northeast Iran: Implications for climate change and agricultural water management. [PDF]

Desert
Aridity indices have been widely applied in dividing climate regimes and monitoring drought events. The knowledge of the aridity index and reference evapotranspiration is very important not only for understanding climate change and its effects on ...
Z. Shirmohammadi Aliakbarkhani, F. Foroughi, S.F. Saberali, H. Nastari Nasrabadi, M.N. Modoodi   +4 more
doaj   +1 more source