Association of Venous Thromboembolism Risk with Atopic Dermatitis and Janus Kinase Inhibitors Treatment: A Mendelian Randomization Study. [PDF]
Chen Z, Wang S, Wang Y.
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Progression of mycosis fungoides in a patient receiving a Janus kinase inhibitor. [PDF]
Stankiewicz JM +6 more
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Real-world comparative effectiveness of sarilumab versus Janus kinase inhibitors as monotherapy in rheumatoid arthritis. [PDF]
Nozaki Y +20 more
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Optimizing Janus kinase inhibitor therapy for ulcerative colitis: a real-world perspective. [PDF]
Akiyama S.
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Intraocular infections following biologicals and Janus Kinase inhibitors. [PDF]
Dutta Majumder P, Kene RD.
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Janus kinase inhibitors in pulmonary and extra-pulmonary sarcoidosis: A case series and a systematic review of the literature. [PDF]
Quaggetto M +7 more
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Janus kinase-1 and Janus kinase-2 inhibitors for treating myelofibrosis
Cochrane Database of Systematic Reviews, 2015Myelofibrosis is a bone marrow disorder characterized by excessive production of reticulin and collagen fiber deposition caused by hematological and non-hematological disorders. The prognosis of myelofibrosis is poor and treatment is mainly palliative.
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The chronic myeloproliferative neoplasms (MPNs) polycythemia vera (PV), essential thrombocytosis (ET), and primary myelofibrosis (MF) are commonly associated with mutations in the Janus kinase gene JAK2. A hallmark of PV is an abundance of red blood cells; ET, too many platelets; and MF, accumulation of neutrophils and monocytes accompanied by bone ...
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The many faces of Janus kinase
Biochemical Pharmacology, 2012Janus kinases have proved to be essential for many immunological processes but there is growing evidence that they also play a critical role in pathogenesis of many diseases including inflammatory diseases and cancer where they promote multiple steps of tumorigenesis.
Matthew M, Seavey, Pawel, Dobrzanski
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Negative Regulation of Janus Kinases
Cell Biochemistry and Biophysics, 2001The precise regulation of both the magnitude and the duration of Janus kinase (JAK) catalytic activity is essential for the cytokine orchestration of many biological processes, and the dysregulation of JAK activity has pathological implications.
R J, Duhé, L H, Wang, W L, Farrar
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