Results 151 to 160 of about 107,749 (252)

Jak out of the box: Targeting Bruton's tyrosine kinase, sialic acid-binding immunoglobulin-like lectin-8, and Janus kinase 1 in food allergy. [PDF]

Ann Allergy Asthma Immunol, 2023
Berin C.
europepmc   +1 more source

Real‐World Outcomes of Baricitinib and Ritlecitinib in Refractory Alopecia Areata: Response Predictors and Relapse After Discontinuation or Dose Reduction

The Journal of Dermatology, EarlyView.
ABSTRACT Baricitinib and ritlecitinib are newly approved systemic Janus kinase (JAK) inhibitors for severe, refractory alopecia areata (AA). Although clinical trials have demonstrated their efficacy, real‐world evidence remains limited, particularly regarding predictors of response and outcomes following treatment interruption or dose tapering.
Rina Hayashi, Saori Takamura, Tomoo Fukuda   +2 more
wiley   +1 more source

Targeted Systemic Therapies for Atopic Dermatitis in Australia: A Narrative Review

Australasian Journal of Dermatology, EarlyView.
ABSTRACT Atopic dermatitis (AD) is a chronic relapsing inflammatory skin disease estimated to affect approximately 30% of children and 10%–15% of adults in Australia. Of those with this condition, one in five is estimated to have moderate‐to‐severe disease.
Diana Rubel, Peter Foley, Kathryn A. Gibson, Anita Townsend, Gabrielle Louise Reppen, William Romero Gallardo   +5 more
wiley   +1 more source

Evaluation of immunohistochemical and gene expression of Janus kinase 1 and Janus kinase 3 in the skin of different clinical types of mycosis fungoides patients - Part 1. [PDF]

An Bras Dermatol
El-Amawy HS, Mohamed Ali BM, Shareef MM, Elgarhy L.   +3 more
europepmc   +1 more source

Randomized Controlled Trial Substudy of Cell-specific Mechanisms of Janus Kinase 1 Inhibition With Upadacitinib in the Crohn's Disease Intestinal Mucosa: Analysis From the CELEST Study. [PDF]

Inflamm Bowel Dis, 2021
Aguilar D, Revilla L, Garrido-Trigo A, Panés J, Lozano JJ, Planell N, Esteller M, Lacerda AP, Guay H, Butler J, Davis JW, Salas A.   +11 more
europepmc   +1 more source

Club Cells in Nasal Epithelial Repair: Insights From an IL‐13‐Induced Inflammatory Model

Allergy, EarlyView.
Four inflammatory endotypes of CRSwNP, defined by eosinophil and neutrophil infiltration, show distinct patterns of basal, club, ciliated, and goblet cell expression in nasal epithelium. Using an ALI‐HNECs model, we demonstrate that IL‐13 impairs mucociliary function by promoting club‐to‐goblet cell differentiation while inhibiting club‐to‐ciliated ...
Zhi‐Qun Huang, Jing Liu, Jing Ye, Li‐Ying Sun, Hsiao Hui Ong, Yang Peng, Bing‐Qi Lin, Jun‐Hao Tu, Ke‐Shuang Wang, Yi‐Shan Xiong, Qing Luo, Mark Thong, Yu Xu, De‐Yun Wang   +13 more
wiley   +1 more source

Loss of Cardiomyocyte Janus Kinase 1 (Jak1) Causes Cardiomyopathy

Journal of Molecular and Cellular Cardiology Plus
Arasakumar Subramani, Kobina Essandoh, Michael Y. Young, Kay-Uwe Wagner, Matthew J. Brody   +4 more
doaj   +1 more source

Rheumatoid Arthritis Preceded by Interstitial Lung Disease Controlled by Long-Term Treatment With the Janus Kinase 1-Selective Inhibitor, Filgotinib: A Case Report. [PDF]

Respirol Case Rep
Sato T, Nakazawa S, Yamamoto S, Nagatani K, Sato K.   +4 more
europepmc   +1 more source

Targeting Immunologic Pathways in Eosinophilic Granulomatosis With Polyangiitis: Translating Emerging Evidence Into Clinical Practice

Allergy, EarlyView.
ABSTRACT Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare and potentially life‐threatening systemic, inflammatory disease with multi‐organ manifestations, variable presentation and complex pathology. Multiple interconnected immunological pathways are implicated in EGPA pathology, including a type‐2 immune response driving predominantly ...
Harold Wilson‐Morkeh, Lior Seluk, Philipp Bosch, Carolina Aguiar, Jens Thiel, Bernhard Hellmich, Michael E. Wechsler, Salman Siddiqui   +7 more
wiley   +1 more source

The Janus kinase 1/2 inhibitor ruxolitinib in COVID-19. [PDF]

Leukemia, 2020
Gozzetti A, Capochiani E, Bocchia M.
europepmc   +1 more source