The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Acute lung injury (ALI) is a severe complication of sepsis, yet the role of lncRNA NORAD in its pathogenesis remains unclear. Using LPS‐stimulated BEAS‐2B and HBEC3‐KT cells as well as cecal ligation and puncture (CLP)‐induced ALI models in C57BL/6 mice, we found that NORAD expression was markedly upregulated and promoted cell injury ...
Han Liu +4 more
wiley +1 more source
Role of Plasma Janus Kinase 2 in Assessment of Disease Activity in Ulcerative Colitis
SVU - International Journal of Medical SciencesBackground: Ulcerative colitis (UC) is a chronic autoimmune disease with increasing incidence worldwide. The pathophysiology of UC is multifactorial, including interplay between immune, gut microbiota, genetic vulnerability, and environment-related ...
Asmaa Mahdy Ghaith +4 more
doaj +1 more source
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Vaccarin is a naturally occurring flavonoid glycoside with cardioprotective properties; however, its involvement in myocardial ischemia–reperfusion (MI/R) injury remains poorly defined. We herein investigated whether vaccarin protects cardiomyocytes from MI/R‐induced dysfunction in vivo and in vitro and examined the associated molecular ...
Han Yang, Mi Zhou, Feng‐Cai Zhang
wiley +1 more source
Development of Potent and Selective Janus Kinase 2/3 Directing PG-PROTACs. [PDF]
ACS Med Chem Lett, 2022 Alcock LJ +14 more
europepmc +1 more source
Dexmedetomidine Suppresses Glutamate-Stimulated Neuronal Injury Via MicroRNA-433/Janus Kinase 2/Signal Transducer and Activator of Transcription 3 Pathway. [PDF]
Iran J Biotechnol, 2023 Zhao L, Huang J, Wu Z, Fu G.
europepmc +1 more source
Mass Spectrometry Insights Into Post‐Translational Modifications in Extracellular Vesicles
Mass Spectrometry Reviews, EarlyView.ABSTRACT Extracellular vesicles (EVs) are membrane‐enclosed structures secreted by virtually all living cells, serving as essential mediators of intercellular communication in both physiological and pathological processes. There is growing interest in their potential applications as biomarkers, therapeutic targets, and drug delivery systems, which ...
Dávid Virág +5 more
wiley +1 more source
A Case Report of Large Bilateral Pulmonary Embolism in a Patient With Janus Kinase 2 (JAK2) Positive Mutation. [PDF]
Cureus, 2022 Khan Z, Besis G.
europepmc +1 more source
Medicine Bulletin, EarlyView.The figure was created in BioRender.com. ABSTRACT Accurate and early diagnosis remains a key challenge in modern disease management. Conventional diagnostic methods often suffer from limitations in sensitivity, spatial resolution, and practical usability.
Zizhuo Du +10 more
wiley +1 more source
Hsp90 Inhibition on the Western Blot: N‐Terminal Versus C‐Terminal Inhibitors in Breast Cancer
Medicinal Research Reviews, EarlyView.ABSTRACT Heat shock protein 90 (Hsp90) is an established and clinically validated anticancer target. By regulating the folding and maturation of diverse client proteins, it is indirectly involved in carcinogenesis. Key breast cancer oncogenic drivers, including estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2, are ...
Jaka Dernovšek +3 more
wiley +1 more source
Safety and efficacy of fedratinib, a selective oral inhibitor of Janus kinase-2 (JAK2), in patients with myelofibrosis and low pretreatment platelet counts. [PDF]
Br J Haematol, 2022 Harrison CN +11 more
europepmc +1 more source