Results 91 to 100 of about 74,496 (193)

The Burden of Alopecia Areata and Management with Baricitinib in the United Arab Emirates: A Narrative Review

Dermatology and Therapy
Alopecia areata is an inflammatory autoimmune disease that presents as non-scarring hair loss in adults and children and causes substantial psychological distress, economic burden, and reduced quality of life for those affected.
Hussein Abdel Dayem, Anwar Al Hammadi, Ashraf Reda, Fatima Albreiki, Ayman Al Naeem, Ahmed Ameen, Mohamed Ahmed, Huda Rajab Ali, Mohamed Elrayes, Gozde Senay, Muna Al Murrawi   +10 more
doaj   +1 more source

Successful treatment of recalcitrant follicular lichen planus (lichen planopilaris) with the topical JAK 1/2 inhibitor ruxolitinib

JEADV Clinical Practice
We report the successful treatment of a patient with refractory follicular lichen planus (LP) with topical ruxolitinib, a Janus kinase (JAK) 1/2 inhibitor, which resulted in significant improvement of lesional skin within 1 month of daily use.
Tanja Fetter, Dagmar Wilsmann‐Theis, Luka deVos‐Hillebrand, Natalija Novak, Joerg Wenzel   +4 more
doaj   +1 more source

Towards Selective Inhibitors of Janus Kinase 3: Identification of a Novel Structural Variation between Janus Kinases 2 and 3

Bulletin of the Korean Chemical Society, 2012
E-mail: chongy@konkuk.ac.krReceived August 13, 2012, Accepted September 6, 2012Key Words : Janus kinase 3 (JAK3), Selective inhibitors, Flavonoid conjugate, Structural variationThe mammalian Janus kinase (JAK) family of intracellularnonreceptor protein tyrosine kinases consists of four iso-forms (JAK1, JAK2, JAK3 and TYK2) that play key roles inthe ...
Mi Kyoung Kim, Youhoon Chong
openaire   +2 more sources

Corrigendum: Granulocyte colony-stimulating factor receptor signalling via Janus kinase 2/signal transducer and activator of transcription 3 in ovarian cancer. [PDF]

, 2015
Corrigendum: Granulocyte colony-stimulating factor receptor signalling via Janus kinase 2/signal transducer and activator of transcription 3 in ovarian ...
N Ahmed (10325708), C Riley (9852419), J Kumar (9868967), DR McCulloch (14470866), FW Fraser (14472564), Alister Ward (13059717)   +5 more
core  

Efficacy of Janus kinase inhibitors in immune-mediated inflammatory diseases a systematic literature review informing the 2024 update of an international consensus statement [PDF]

Objective This systematic literature review (SLR) on efficacy outcomes was performed to inform the 2024 update of the expert consensus statement on the treatment of immune-mediated inflammatory diseases (IMIDs) with Janus kinase inhibitors (JAKi ...
Nash, P, Tanaka, Y, Wit, M. de, Trauner, M., Sattar, N, Baraliakos, X, Sattar, N., Aletaha, D., Smolen, JS, Primdahl, J, Primdahl, J., Nash, P., de Wit, M, Mcinnes, I.B., Schoones, JW, Kerschbaumer, A., Baraliakos, X., Trauner, M, Dörner, T, Aletaha, D, McInnes, IB, Konzett, V., Fleischmann, R, Fleischmann, R., Dorner, T., Schoones, J.W., Konzett, V, Tanaka, Y., Winthrop, K, Winthrop, K., Smolen, J.S., et al.   +31 more
core   +2 more sources

Discovery of Selective Binding Molecules for the Pseudokinase Domain of Janus Kinase 2 [PDF]

, 2022
Janus Kinase 2 (JAK2) is a nonreceptor tyrosine kinase that plays an important role in the regulation of hematopoiesis through the JAK-STAT pathway.
Liosi, Maria-Elena
core   +1 more source

Association between Polymorphism in the Janus Kinase 2 (JAK2) Gene and Selected Performance Traits in Cattle and Sheep. [PDF]

Animals (Basel), 2023
Oster N, Szewczuk MA, Zych S, Stankiewicz T, Błaszczyk B, Wieczorek-Dąbrowska M.   +5 more
europepmc   +1 more source

Age- and gender-based frequency and association of common myeloproliferative mutations in a South African cohort

African Journal of Laboratory Medicine
Background: Age, gender, and mutation type are key risk factors for myeloproliferative neoplasms (MPNs). Africa remains under-represented in global cancer statistics due to limited population-based genomic data.
Bathabile Mbele, Kapila Bhowan, Brendon Roets   +2 more
doaj   +1 more source

Advancing therapeutic frontiers: a pipeline of novel drugs for UC management

Frontiers in Gastroenterology
Ulcerative colitis is a chronic inflammatory bowel disease with rising global prevalence. Despite therapeutic advances including biologic agents targeting tumor necrosis factor-alpha, integrins, and interleukin pathways, alongside Janus kinase inhibitors
Luisa Bertin, Alessandro Massano, Carlo Redavid, Marco Scarpa, Cesare Ruffolo, Imerio Angriman, Andrea Buda, Fabiana Zingone, Brigida Barberio, Edoardo Vincenzo Savarino   +9 more
doaj   +1 more source

Janus kinase 2 inhibition by pacritinib as potential therapeutic target for liver fibrosis. [PDF]

Hepatology, 2023
Torres S, Ortiz C, Bachtler N, Gu W, Grünewald LD, Kraus N, Schierwagen R, Hieber C, Meier C, Tyc O, Joseph Brol M, Uschner FE, Nijmeijer B, Welsch C, Berres ML, Garcia-Ruiz C, Fernandez-Checa JC, Trautwein C, Vogl TJ, Zeuzem S, Trebicka J, Klein S.   +21 more
europepmc   +1 more source