TYK2 in Immune Responses and Treatment of Psoriasis
Journal of Inflammation Research, 2022 Lin Shang,* Jiali Cao,* Siqi Zhao, Jingya Zhang, Yanling He Department of Dermatology, Capital Medical University Affiliated Beijing Chaoyang Hospital, Beijing, People’s Republic of China*These authors contributed equally to this ...
Shang L, Cao J, Zhao S, Zhang J, He Y
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PREFERENTIAL NUCLEAR ACCUMULATION OF JAK2V617F IN CD34+ BUT NOT IN GRANULOCYTIC, MEGAKARYOCYTIC OR ERYTHROID CELLS OF PATIENTS WITH PHILADELPHIA-NEGATIVE MYELOPROLIFERATIVE NEOPLASIA. [PDF]
, 2010 Recently, Dawson et al. identified a previously unrecognized nuclear role for JAK2 in the phosphorylation of the tyrosine 41 of the histone H3 with the exclusion of HP1a from chromatin and resulting in a disregulation of several JAK2-regulated genes such
Fabrizio Pane +10 more
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Journal of Clinical Ophthalmology and ResearchPurpose: The purpose of this study was to document secondary polycythemia (SP)-associated retinal changes and the favorable role of phlebotomy in the treatment of SP-induced retinal complications.
Alok Pratap Singh +5 more
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Janus kinase 2 and signal transducer and activator of transcription 3 activation is not essential for CCL3-, CCL5- or CCL8-induced chemotaxis [PDF]
, 2013 Chemokine receptors induce cell migration, but the molecular basis of the signal cascade involved is not completely understood. Therefore, we investigated here the molecular mechanisms of CCL3-, CCL5- and CCL8-induced cells migration and investigated ...
Mueller, Anja +9 more
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Primary myelofibrosis: current therapeutic options
Revista Brasileira de Hematologia e HemoterapiaPrimary myelofibrosis is a Philadelphia-negative myeloproliferative neoplasm characterized by clonal myeloid expansion, followed by progressive fibrous connective tissue deposition in the bone marrow, resulting in bone marrow failure.
Paula de Melo Campos
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Doxorubicin has a synergistic cytotoxicity with cucurbitacin B in anaplastic thyroid carcinoma cells
Tumor Biology, 2017 In this study, the combined effect of doxorubicin with cucurbitacin B on survival of anaplastic thyroid carcinoma cells was evaluated. For experiments, 8505C and CAL62 human anaplastic thyroid carcinoma cells were used.
Si Hyoung Kim +6 more
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Revisiting Janus Kinase Inhibitors in Hospitalized COVID-19: Evidence for Baricitinib’s Superiority and the Absence of a Class Effect [PDF]
Lei Gu,1,* Jing Lin,2,* Jian Yue,3,* Zeyi Liu,1 Jian-an Huang1 1Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People’s Republic of China; 2Department of ...
Liu Z, Gu L, Lin J, Huang JA, Yue J
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Janus kinase 1/2 inhibition for the treatment of autoinflammation associated with heterozygous TNFAIP3 mutation [PDF]
, 2019 We report a case of autoinflammation caused by a heterozygous variant in TNFAIP3 manifesting as progressive neuroinflammation. Mutant A20 protein failed to control interferon-dependent transcription. We demonstrate excellent therapeutic response to Janus
Mulhern, CM +7 more
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Omental sclerosing extramedullary hematopoietic tumors in Janus kinase-2 negative myelofibrosis: Caveat at frozen section [PDF]
, 2014 Sclerosing extramedullary hematopoietic tumors (SEMHTs) are associated with chronic myeloproliferative neoplasms. These extremely rare mass lesions were first described in kidney and peritoneum.
Dharmesh J Balsarkar +3 more
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Avicenna Journal of Medicine, 2017 Objective: We aimed to investigate the frequency of Janus kinase 2 ( JAK2) mutations in cases with chronic myeloproliferative disorders (CMDs), and the relationship between the presence of JAK2 mutation and leukocytosis and splenomegaly, retrospectively.
Ismail Yildiz, Osman Yokuş, Habip Gedik
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