Results 51 to 60 of about 74,496 (193)

JAK 1-3 inhibitors and TYK-2 inhibitors in dermatology: Practical pearls for the primary care physician

Journal of Family Medicine and Primary Care
Guidelines for primary care clinicians on monitoring and safety guidelines regarding Janus kinase and tyrosine kinase 2 inhibitors in the treatment of inflammatory skin conditions are often unclear.
Abigail Beard, Shannon C. Trotter
doaj   +1 more source

The prognostic impact of germline 46/1 haplotype of Janus kinase 2 in cytogenetically normal acute myeloid leukemia

Haematologica, 2011
Background Prognostic risk stratification according to acquired or inherited genetic alterations has received increasing attention in acute myeloid leukemia in recent years.
Sarolta Nahajevszky, Hajnalka Andrikovics, Arpad Batai, Emma Adam, Andras Bors, Judit Csomor, Laszlo Gopcsa, Magdalena Koszarska, Andras Kozma, Nora Lovas, Sandor Lueff, Zoltan Matrai, Nora Meggyesi, Janos Sinko, Andrea Sipos, Andrea Varkonyi, Sandor Fekete, Attila Tordai, Tamas Masszi   +18 more
doaj   +1 more source

Cytokine-induced Src homology 2 protein (CIS) promotes T cell receptor-mediated proliferation and prolongs survival of activated T cells [PDF]

, 2000
Copyright @ 2000 The Rockefeller University Press. This article is shared under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/ and http://creativecommons ...
Sjögren, HO, Paulsson, KM, Anette Sundstedt, Xu, X., Chen, S, Xiufeng Xu, Chen, Shangwu, Sundstedt, Anette, Karlsson, Stefan, Hans-Olov Sjögren, Karlsson, S, Li, Suling, Paulsson, Kajsa, Wang, P, Kajsa M. Paulsson, Sjögren, Hans Olov, Suling Li, Sundstedt, A, Stefan Karlsson, Xu, X, Anderson, P, Ping Wang, Wang, Ping, Shangwu Chen, Per Anderson, andersson, Per   +25 more
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miR-101 Promotes Breast Cancer Cell Apoptosis by Targeting Janus Kinase 2

Cellular Physiology and Biochemistry, 2014
Aims: microRNA-101 (miR-101) is down-regulated in several cancers. In this study, we explored the effects of dysregulated miR-101 on breast cancer cells and the underlying mechanisms. Methods: miR-101 level was quantified by real-time RT-PCR.
Lu Wang, Linqiang Li, Rui Guo, Xuelian Li, Ying Lu, Xiaoxiang Guan, Samuel Chege Gitau, Leimin Wang, Chaoqian Xu, Baofeng Yang, Hongli Shan   +10 more
doaj   +1 more source

Screening for Janus kinase-2 exon 12 mutations among Janus kinase-2 V617F-negative polycythemia vera suspected Iraqi patients

Iraqi Journal of Hematology
BACKGROUND: Diagnosis of myeloproliferative neoplasms including polycythemia vera (PV) has been greatly improved following the identification of driver mutations at exon 12 and exon 14 of the Janus Kinase 2 (JAK2) gene. There are limited academic studies
Mushtaq M. Khazeem, Alaa Fadhil Alwan
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Constitutive nuclear localization of Janus kinases 1 and 2. [PDF]

Endocrinology, 1996
Both GH and the GH receptor have been reported to undergo rapid nuclear translocation. Janus kinases (JAK) 1 and 2 have been implicated in GH receptor signaling, and both of these kinases are phosphorylated by GH stimulation. In this report, we have investigated the subcellular distribution of JAK1 and JAK2.
Lobie, P.E., Ronsin, B., Silvennoinen, O., Haldosén, L.-A., Norstedt, G., Morel, G.   +5 more
openaire   +2 more sources

IGF-1 and PDGF-bb suppress IL-1β-induced cartilage degradation through down-regulation of NF-κB signaling: involvement of Src/PI-3K/AKT pathway. [PDF]

, 2011
Interleukin-1β (IL-1β) is a pro-inflammatory cytokine that plays a key role in the pathogenesis of osteoarthritis (OA). Growth factors (GFs) capable of antagonizing the catabolic actions of cytokines may have therapeutic potential in the treatment of OA.
Franziska Busch, Azadeh Montaseri, Jafar Soleimani Rad, Busch, Franziska, Montaseri, Azadeh, Rad, Jafar Soleimani, Mehdi Shakibaei, Ali Mobasheri, Constance Aldinger, Aldinger, Constance, Shakibaei, Mehdi, Mobasheri, Ali, Constanze Buhrmann, Buhrmann, Constanze   +13 more
core   +1 more source

The role of erythropoietin levels and other hematological factors in the diagnosis of polycythemia vera in Iraqi patients

Iraqi Journal of Hematology, 2023
BACKGROUND: According to the World Health Organization (WHO), erythropoietin (EPO) is only a minor criterion for the diagnosis of polycythemia vera (PV), but its diagnostic validity is controversial.
Aseel Modhfer Al Dayyeni, Bassam T Al-Gailani, Mohammed Ghanim Mahdi   +2 more
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Clinical characteristics of a patient with de novo acute promyelocytic leukemia with JAK2 v617f mutation

Hematology, 2022
Background: The V617F mutation of Janus-associated kinase 2 (JAK2) is common in myeloproliferative neoplasms (MPN). JAK2 V617F mutation can be detected in patients with de novo acute myeloid leukemia (AML), but de novo acute promyelocytic leukemia (APL ...
Yi-zhi Jiang, Zhong-ling Wei, Na-na Wang, Chen Huang, Jun Huang, Jia-wei Yan, Ran Wang, Zheng-zhi Yu, Dong-ping Huang   +8 more
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Use of Janus kinase inhibitors in COVID-19: a prospective observational series in 522 individuals [PDF]

, 2021
Janus kinase (JAK) inhibitors for the treatment of hospitalised patients with COVID-19 have been extensively studied. Initially, at the start of the pandemic outside of China, baricitinib was shown using artificial intelligence to have a potential dual ...
Kruglova, Tatiana, Tatiana Kruglova (18134782), Zagrebneva, Alena, Alena Zagrebneva (18134803), Vertkin, Arkady, Melikhov, Oleg, Gleb Putsman (18134794), Prokhorovich, Elena, Rodoman, Grigory, Stebbing, Justin, Oleg Melikhov (18134779), Melkonyan, Georgy, Putsman, Gleb, Lytkina, Karine, Justin Stebbing (181883), Georgy Melkonyan (18134788), Elena Prokhorovich (18134791), Arkady Vertkin (18134800), Karine Lytkina (18134785), Grigory Rodoman (18134797)   +19 more
core   +1 more source