Results 31 to 40 of about 74,496 (193)

Janus kinase 2 negative polycythemia vera [PDF]

Asian Biomedicine, 2015
Abstract Background A Janus kinase 2 (JAK2) mutation polycythemia vera (PV) is a common manifestation of stem cell disorder. However, available data on the clinical and treatment response of JAK2-negative PV patients are limited ...
Pravinwan Thungthong, Supat Chamnanchanunt, Tawatchai Suwanban, Chajchawan Nakhakes, Kunapa Iam-arunthai   +4 more
openaire   +1 more source

Pyoderma gangrenosum in association with Janus kinase 2 (JAK2V617F) mutation [PDF]

, 2013
Pyoderma gangrenosum (PG) commonly occurs in association with various haematological and inflammatory disorders. We report a new association, a Janus kinase (JAK)2 mutation, in a 63-year-old patient with PG.
Levell, N. J., Macbeth, A. E., Palanivel, J. A.   +2 more
core   +1 more source

Development of an enzyme-coupled activity assay for Janus kinase 2 inhibitor screening

SLAS Discovery, 2023
JAK2 transmits signals of several important cytokines, such as growth hormone and erythropoietin. The interest toward the therapeutic targeting of JAK2 was boosted in 2005, when the somatic JAK2 V617F mutation, responsible for the majority of ...
Angelika Pölläniemi, Anniina Virtanen, Olli Silvennoinen, Teemu Haikarainen   +3 more
doaj   +1 more source

Naphthyl ketones: A new class of Janus kinase 3 inhibitors [PDF]

, 2000
Potent inhibition of Janus kinase 3 was found for a series of naphthyl(β-aminoethyl)ketones (e.g. 7, pIC50 = 7.1 ± 0.3). Further studies indicated that these compounds fragment in less than 1 h by retro-Michael reaction in the Jak3 in vitro ELISA assay ...
Tang, Eric, Bowyer, Jonathan, Torr, Vanessa, James, Daniel S., Rankine, Neil, Bamford, Andrea M., Culbert, Eric J., Brown, George R.   +7 more
core   +1 more source

Chronic myeloid leukemia stem cells are not dependent on Bcr-Abl kinase activity for their survival [PDF]

, 2012
Recent evidence suggests CML stem cells are insensitive to kinase inhibitors and responsible for minimal residual disease in treated patients. We investigated whether CML stem cells, in a transgenic mouse model of CML-like disease or derived from ...
Allan, Elaine K., Mueller-Tidow, Carsten, Nicolini, Franck E., Bhatia, Ravi, Brunton, Valerie G, Myssina, Svetlana, Hamilton, Ashley, Mysina, Svetlana, Müller-Tidow, Carsten, Koschmieder, Steffen, Allan, Elaine K, Helgason, G. Vignir, Helgason, G Vignir, Brunton, Valerie G., Schemionek, Mirle, Zhang, Bin, Holyoake, Tessa L., Holyoake, Tessa L, Nicolini, Franck E   +18 more
core   +1 more source

Use of Janus Kinase Inhibitors for Granulomatous Dermatoses: A Systematic Review [PDF]

, 2023
Granulomatous dermatoses (GDs) are heterogeneous inflammatory skin conditions involving granuloma formation and macrophage accumulation. While the use of Janus kinase inhibitors (JAKi) for GDs remains novel, this systematic review summarizes the current ...
Sood, S (via Mendeley Data)
core   +1 more source

Identification of the protein kinases Pyk3 and Phg2 as regulators of the STATc-mediated response to hyperosmolarity [PDF]

, 2014
Cellular adaptation to changes in environmental osmolarity is crucial for cell survival. In Dictyostelium, STATc is a key regulator of the transcriptional response to hyperosmotic stress. Its phosphorylation and consequent activation is controlled by two
Christoph S Clemen, Linh Hai Vu (527338), Clemen, Christoph S., Na, Jianbo, Christoph S. Clemen (130148), Araki, Tsuyoshi, Linh Hai Vu, Na Jianbo, Araki Tsuyoshi, Tsuyoshi Araki (506033), Williams Jeffrey G., Eichinger Ludwig, Vu Linh Hai, Eichinger, Ludwig, Jeffrey G Williams, Williams, Jeffrey G., Jianbo Na, Ludwig Eichinger, Tsuyoshi Araki, Jianbo Na (12352), Clemen Christoph S., Vu, Linh Hai, Jeffrey G. Williams (335697), Ludwig Eichinger (11966)   +23 more
core   +1 more source

Suggested modification of Janus associated kinase 2-tree algorithm for the detection of Janus associated kinase 2 V617F-positive polycythemia rubra vera patients in Pakistani population

Journal of Applied Hematology, 2020
OBJECTIVE: The Janus associated kinase-2 (JAK2 mutation V617F and exon 12) is detected in most polycythemia vera (PV) patients. It can easily be picked up by real-time polymerase chain reaction (PCR).
Mohammad Abdul Naeem, Mohammad Iqbal
doaj   +1 more source

ORF3a Protein of Severe Acute Respiratory Syndrome Coronavirus 2 Inhibits Interferon-Activated Janus Kinase/Signal Transducer and Activator of Transcription Signaling via Elevating Suppressor of Cytokine Signaling 1

Frontiers in Microbiology, 2021
Coronavirus disease 2019 (COVID-19) has caused a crisis to global public health since its outbreak at the end of 2019. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the pathogen of COVID-19, appears to efficiently evade the host immune ...
Rong Wang, Xiaofeng Yang, Mingke Chang, Ziyang Xue, Weirong Wang, Liang Bai, Sihai Zhao, Enqi Liu   +7 more
doaj   +1 more source

Janus Kinase 2 Influences Growth Hormone Receptor Metalloproteolysis [PDF]

Endocrinology, 2006
GH signals through the GH receptor (GHR), a cytokine receptor superfamily member that couples to the cytoplasmic tyrosine kinase, Janus kinase 2 (JAK2). In addition to its role in signaling, we recently implicated JAK2 in the regulation of cell surface GHR abundance by modulation of GHR trafficking and mature GHR stability.
Kimberly, Loesch, Luqin, Deng, Jon W, Cowan, Xiangdong, Wang, Kai, He, Jing, Jiang, Roy A, Black, Stuart J, Frank   +7 more
openaire   +2 more sources