Results 41 to 50 of about 24,855,408 (292)

Development of an enzyme-coupled activity assay for Janus kinase 2 inhibitor screening

SLAS Discovery, 2023
JAK2 transmits signals of several important cytokines, such as growth hormone and erythropoietin. The interest toward the therapeutic targeting of JAK2 was boosted in 2005, when the somatic JAK2 V617F mutation, responsible for the majority of ...
Angelika Pölläniemi, Anniina Virtanen, Olli Silvennoinen, Teemu Haikarainen   +3 more
doaj   +1 more source

Identification of autophosphorylation sites in eukaryotic elongation factor-2 kinase [PDF]

, 2012
eEF2K [eEF2 (eukaryotic elongation factor 2) kinase] phosphorylates and inactivates the translation elongation factor eEF2. eEF2K is not a member of the main eukaryotic protein kinase superfamily, but instead belongs to a small group of so-called ...
Hussain, Nusrat, Proud, Christopher G, Proud, C., Wang, Xuemin, Rider, M., Rider, Mark H, Pyr Dit Ruys, S., Vertommen, D., Rider, Mark, Pyr Dit Ruys, Sébastien, Herinckx, Gaëtan, Vertommen, Didier, Herinckx, G., Smith, Ewan M, Wang, X., Smith, E., Hussain, N.   +16 more
core   +1 more source

Janus Kinase 2 Influences Growth Hormone Receptor Metalloproteolysis [PDF]

Endocrinology, 2006
GH signals through the GH receptor (GHR), a cytokine receptor superfamily member that couples to the cytoplasmic tyrosine kinase, Janus kinase 2 (JAK2). In addition to its role in signaling, we recently implicated JAK2 in the regulation of cell surface GHR abundance by modulation of GHR trafficking and mature GHR stability.
Kimberly, Loesch, Luqin, Deng, Jon W, Cowan, Xiangdong, Wang, Kai, He, Jing, Jiang, Roy A, Black, Stuart J, Frank   +7 more
openaire   +2 more sources

In vivo and ex vivo regulation of visfatin production by leptin in human and murine adipose tissue : role of mitogen-activated protein kinase and phosphatidylinositol 3-kinase signaling pathways [PDF]

, 2009
Visfatin is an adipogenic adipokine with increased levels in obesity, properties common to leptin. Thus, leptin may modulate visfatin production in adipose tissue (AT).
Brown, James, Clifford J. Bailey, Jing Chen, Bee K. Tan, Tan, Bee K., Bailey, C. J. (Clifford J.), Adya, Raghu, Randeva, Harpal S., Vinod Menon, James Brown, Hendrik Lehnert, Menon, Vinod, Raghu Adya, Manjunath Ramanjaneya, Harpal S. Randeva, Ramanjaneya, Manjunath, Chen, Jing, Lehnert, Hendrik   +17 more
core   +2 more sources

Association of Janus kinase 1 and 2 expression with clinical indices in diabetic kidney disease

Journal of Research in Medical Sciences
Background: Diabetic Kidney Disease (DKD) is a prevalent complication of uncontrolled hyperglycemia that imposes a considerable burden on the health system due to the need for renal replacement therapy in the long term.
Mahboobeh Freidoon, Naghmeh Sayadi, Sara Assadiasl, Hadi Kazemzadehghadim, Narjes Soleimanifar, Maryam Sadr, Hanieh Mojtahedi, Maryam Ahmadi, Mohammad Hossein Nicknam   +8 more
doaj   +1 more source

Knockdown of long non-coding RNA HOXD-AS1 inhibits gastric cancer cell growth via inactivating the JAK2/STAT3 pathway

Tumor Biology, 2017
Long non-coding RNA HOXD-AS1 (HOXD cluster antisense RNA 1) has been demonstrated to be closely associated with the progression of several tumors. However, the biological function of HOXD-AS1 and the underlying molecular mechanism in gastric cancer are ...
Li Zheng, Jiangtao Chen, Zhongyong Zhou, Zhikuan He   +3 more
doaj   +1 more source

Janus Kinase 2: A Critical Target in Chronic Myelogenous Leukemia [PDF]

Cancer Research, 2006
Abstract The Bcr-Abl tyrosine kinase is the causative factor in most chronic myelogenous leukemia (CML) patients. We have shown that Bcr-Abl is associated with a cluster of signaling proteins, including Janus kinase (Jak) 2, growth factor receptor binding protein 2–associated binder (Gab) 2, Akt, and glycogen synthase kinase (GSK)-3β.
Ajoy K, Samanta, Hui, Lin, Tong, Sun, Hagop, Kantarjian, Ralph B, Arlinghaus   +4 more
openaire   +2 more sources

Cholesterol efflux to apoA-I in ABCA1-expressing cells is regulated by Ca2+-dependent calcineurin signaling

Journal of Lipid Research, 2010
ATP-binding cassette transporter A1 (ABCA1) is required for the lipidation of apolipoprotein A-I (apoA-I), although molecular mechanisms supporting this process remain poorly defined.
Joel Karwatsky, Loretta Ma, Fumin Dong, Xiaohui Zha   +3 more
doaj   +1 more source

Suggested modification of Janus associated kinase 2-tree algorithm for the detection of Janus associated kinase 2 V617F-positive polycythemia rubra vera patients in Pakistani population

Journal of Applied Hematology, 2020
OBJECTIVE: The Janus associated kinase-2 (JAK2 mutation V617F and exon 12) is detected in most polycythemia vera (PV) patients. It can easily be picked up by real-time polymerase chain reaction (PCR).
Mohammad Abdul Naeem, Mohammad Iqbal
doaj   +1 more source

ORF3a Protein of Severe Acute Respiratory Syndrome Coronavirus 2 Inhibits Interferon-Activated Janus Kinase/Signal Transducer and Activator of Transcription Signaling via Elevating Suppressor of Cytokine Signaling 1

Frontiers in Microbiology, 2021
Coronavirus disease 2019 (COVID-19) has caused a crisis to global public health since its outbreak at the end of 2019. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the pathogen of COVID-19, appears to efficiently evade the host immune ...
Rong Wang, Xiaofeng Yang, Mingke Chang, Ziyang Xue, Weirong Wang, Liang Bai, Sihai Zhao, Enqi Liu   +7 more
doaj   +1 more source