Adenosine-Stimulated Adrenal Steroidogenesis Involves the Adenosine a(2a) and a(2b) Receptors and the Janus Kinase 2-Mitogen-Activated Protein Kinase Kinase-Extracellular Signal-Regulated Kinase Signaling Pathway [PDF]
, 2009 Adenosine promotes adrenal steroidogenesis in vitro and in vivo. However, the underlying signaling mechanisms of this event and the function of the adenosine receptor subtypes in adrenal cells remain to be elucidated. Expression of A(1), A(2A), A(2B) and
CHEN, YUNG-CHIA;HUANG, SHIH-HORNG;WANG, SEU-MEI +1 more
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Rapid resolution of non-segmental vitiligo in a patient treated with abrocitinib: A case report
SAGE Open Medical Case ReportsVitiligo is a common, autoimmune, depigmenting disorder of the skin. Janus Kinase inhibitors have emerged as promising topical and oral therapeutic options for vitiligo.
Seyyon Satkunanathan +3 more
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Identification of SH2-Bβ as a potent cytoplasmic activator of the tyrosine kinase Janus kinase 2 [PDF]
Proceedings of the National Academy of Sciences, 1999 Janus kinases (JAKs) are cytoplasmic tyrosine kinases critical for signaling by growth hormone (GH) and many other ligands that bind to members of the cytokine receptor superfamily. SH2-Bβ was previously identified as a JAK2-interacting protein that is tyrosyl phosphorylated in response to GH and other cytokines that activate JAK2.
L, Rui, C, Carter-Su
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Discovery of Potent and Highly Selective Thienopyridine Janus Kinase 2 Inhibitors [PDF]
, 2016 Developing Janus kinase 2 (Jak2) inhibitors has become a significant focus for small molecule drug discovery programs in recent years due to the identification of a Jak2 gain-of-function mutation in the majority of patients with myeloproliferative ...
Elizabeth Doherty (2134036) +21 more
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Nature CommunicationsTofacitinib, a pan–Janus kinase inhibitor, and the Janus kinase 1–preferential inhibitors Upadacitinib and Filgotinib are approved for the treatment of ulcerative colitis, yet their molecular mechanisms of action remain incompletely understood.
Beibei Liu +32 more
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Leptin receptor signaling via Janus kinase 2/Signal transducer and activator of transcription 3 impacts on ovarian cancer cell phenotypes [PDF]
, 2017 Leptin receptor signaling via Janus kinase 2/Signal transducer and activator of transcription 3 impacts on ovarian cancer cell ...
Tamsyn Crowley (13097181) +4 more
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Effects of hyperactive Janus kinase 2 signaling in mammary epithelial cells [PDF]
, 2002 Prolactin, the Janus kinase 2 (JAK2) and the signal transducer and activator of transcription 5 (STAT5) are important for mammary gland development and have also been implicated in development and growth of breast tumors.
Haldosén, LA +4 more
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Frequent Klebsiella pneumoniae Urinary Tract Infections in a Patient Treated with Ruxolitinib
Antibiotics, 2019 Ruxolitinib is a targeted agent that inhibits Janus 2 Kinase and is approved for use in Polycythemia Vera and Primary Myelofibrosis. Its mechanism of action involves inhibition of cellular proliferation via the Janus kinase/signal transducer and ...
Ramy M. Hanna +3 more
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Effect of tofacitinib, a Janus kinase inhibitor, on haematological parameters during 12 weeks of psoriasis treatment [PDF]
, 2013 BackgroundThe Janus kinase (JAK) inhibitor, tofacitinib, has shown efficacy for the treatment of psoriasis in a phase IIb trial (A3921047; NCT00678210).ObjectivesTo report haematology data from the phase IIb trial, given the importance of JAK-dependent ...
Valdez, H +10 more
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Successful Treatment of Severe Nail Lichen Planus with Janus Kinase 1 Inhibitor Abrocitinib [PDF]
Yingzhi Luo,1,* Jian Wu,2,* Xingyun Zhao,1,* Ping Yang,1 Yunmi Qiu,1 Liming Wu,1 Jianbo Zhong1 1Department of Dermatology, Affiliated Hangzhou First People’s Hospital, School of Medicine, Westlake University, Hangzhou, Zhejiang ...
Qiu Y +6 more
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