Distinct clinical characteristics of myeloproliferative neoplasms with calreticulin mutations
Haematologica, 2014 Somatic insertions/deletions in the calreticulin gene have recently been discovered to be causative alterations in myeloproliferative neoplasms. A combination of qualitative and quantitative allele-specific polymerase chain reaction, fragment-sizing ...
Hajnalka Andrikovics +13 more
doaj +1 more source
Janus kinase (JAK) inhibitors in the treatment of neoplastic and inflammatory disorders
Pharmacological Research, 2022 The Janus kinase (JAK) family of nonreceptor protein-tyrosine kinases consists of JAK1, JAK2, JAK3, and TYK2 (Tyrosine Kinase 2). Each of these proteins contains a JAK homology pseudokinase (JH2) domain that interacts with and regulates the activity of ...
Robert Roskoski, Jr.
doaj +1 more source
Janus Kinase Inhibitors: Safety in Patients With Psoriatic Arthritis
, 2022 Janus kinase inhibitors (JAKi; or Jakinibs) have become widely prescribed around the world for a variety of immune-mediated inflammatory diseases, including psoriatic arthritis.
Nash, P
core +1 more source
Janus Kinase Deregulation in Leukemia and Lymphoma [PDF]
, 2012 Genetic alterations affecting members of the Janus kinase (JAK) family have been discovered in a wide array of cancers and are particularly prominent in hematological malignancies.
Chen, Edwin +5 more
core +1 more source
The Janus kinase 1/2 inhibitor ruxolitinib in COVID-19 [PDF]
Leukemia, 2020 La Rosee F, Bremer HC, Gehrke I, Kehr A, Hochhaus A, Birndt S, et al. The Janus kinase 1/2 inhibitor ruxolitinib in COVID-19 with severe systemic hyperinflammation. Leukemia. 2020;34:1805–15. https://doi.org/10.1038/s41375-020-0891-0. CAS Article PubMed Google Scholar Download references Division of Hematology, University of Siena, Siena, Italy ...
Gozzetti, Alessandro +2 more
openaire +4 more sources
Over-expression of MAP kinase phosphatase-2 enhances adhesion molecule expression and protects against apoptosis in human endothelial cells [PDF]
, 2010 In this study we used adenovirus infection to overexpress the dual specific phosphatase, MAP kinase phosphatase-2 (MKP-2), in human umbilical vein endothelial cells and examined inflammatory protein expression and apoptosis, two key features of ...
Cadalbert, Laurence +3 more
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Polisitemia vera; aspek klinis dan tatalaksana terbaru
JKS (Jurnal Kedokteran Syiah Kuala), 2020 Abstrak. Polisitemia Vera (PV) adalah gangguan kronis klonal mieloproliperatif yang ditandai dengan peningkatan hebat dalam jumlah sel darah merah dan volume darah total, dan biasanya disertai dengan leukositosis, trombositosis dan splenomegali.
Muhammad Riswan +2 more
doaj +1 more source
Janus kinase 2 activation mechanisms revealed by analysis of suppressing mutations [PDF]
Journal of Allergy and Clinical Immunology, 2019 Bobin George Abraham +2 more
exaly +2 more sources
MAP kinase phosphatase-2 plays a critical role in response to infection by Leishmania mexicana [PDF]
, 2010 In this study we generated a novel dual specific phosphatase 4 (DUSP4) deletion mouse using a targeted deletion strategy in order to examine the role of MAP kinase phosphatase-2 (MKP-2) in immune responses.
McGachy, H.A. +9 more
core +4 more sources
Hepatology, EarlyView., 2022 KAT7‐acetylated and cytoplasm‐translocated G‐protein GαS enhances IL‐6 effect and drives HCC progenitor cell progression. Abstract Background and Aims Hepatocarcinogenesis goes through HCC progenitor cells (HcPCs) to fully established HCC, and the mechanisms driving the development of HcPCs are still largely unknown.
Ye Zhou +15 more
wiley +1 more source