Results 171 to 180 of about 399,504 (355)

Age- and gender-based frequency and association of common myeloproliferative mutations in a South African cohort

African Journal of Laboratory Medicine
Background: Age, gender, and mutation type are key risk factors for myeloproliferative neoplasms (MPNs). Africa remains under-represented in global cancer statistics due to limited population-based genomic data.
Bathabile Mbele, Kapila Bhowan, Brendon Roets   +2 more
doaj   +1 more source

Controlled release of human growth hormone fused with a human hybrid Fc fragment through a nanoporous polymer membrane [PDF]

Nanotechnology has been applied to the development of more effective and compatible drug delivery systems for therapeutic proteins. Human growth hormone (hGH) was fused with a hybrid Fc fragment containing partial Fc domains of human IgD and IgG(4) to ...
Cha, HJ, CHOI, KWAN YONG, Jang, DS, Jin, KS, Kim, ES, Kim, JK, Lee, MN, SUNG, YOUNG CHUL, Yang, SY   +8 more
core   +1 more source

Curcumin Suppresses Janus Kinase-STAT Inflammatory Signaling through Activation of Src Homology 2 Domain-Containing Tyrosine Phosphatase 2 in Brain Microglia [PDF]

, 2003
Hak Yong Kim, Eun Jung Park, Eun-hye Joe, Ilo Jou   +3 more
openalex   +1 more source

New era for myelofibrosis treatment with novel agents beyond Janus kinase‐inhibitor monotherapy: Focus on clinical development of BCL‐X_L/BCL‐2 inhibition with navitoclax [PDF]

, 2023
Naveen Pemmaraju, Jacqueline S. Garcia, Andrew C. Perkins, Jason G. Harb, Andrew J. Souers, Michael E. Werner, Christopher M. Brown, Francesco Passamonti   +7 more
openalex   +1 more source

Interleukin (IL)‐5, Eosinophils and IL‐5 Pathway Inhibitors in Eosinophilic Granulomatosis with Polyangiitis.

Arthritis &Rheumatology, Accepted Article.
Alvise Berti, Christian Pagnoux
wiley   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Role of Plasma Janus Kinase 2 in Assessment of Disease Activity in Ulcerative Colitis

SVU - International Journal of Medical Sciences
Background: Ulcerative colitis (UC) is a chronic autoimmune disease with increasing incidence worldwide. The pathophysiology of UC is multifactorial, including interplay between immune, gut microbiota, genetic vulnerability, and environment-related ...
Asmaa Mahdy Ghaith , Abeer Mahmoud Ibraheem , Ezzat Ali , Fatma Ibrahim Dwedar , Hussien Mahmoud Hussien   +4 more
doaj   +1 more source

SAT0020 MOMELOTINIB, A JANUS KINASE 1/2 AND ACTIVIN RECEPTOR 1 INHIBITOR, AMELIORATES JOINT INFLAMMATION, SYSTEMIC TH17 DIFFERENTIATION AND ARTHRITIS-LINKED ANEMIA IN PRE-CLINICAL AUTOIMMUNE RA [PDF]

, 2020
Piotr Tymoszuk, Verena Petzer, Malte Aßhoff, Andrea Schroll, M. Seifert, Richard A. Hansen, Slobodan Milutinović, B. Strouse, Christian A. Hassig, Günter Weiß, Igor Theurl   +10 more
openalex   +1 more source

Supplementary Figure 2 from Pyridone 6, A Pan-Janus–Activated Kinase Inhibitor, Induces Growth Inhibition of Multiple Myeloma Cells [PDF]

, 2023
Laura Pedranzini, Tobias Dechow, Marjan Berishaj, Raymond L. Comenzo, Ping Zhou, Janeen Azare, William G. Bornmann, Jacqueline Bromberg   +7 more
openalex   +1 more source

Development of Potent and Selective Janus Kinase 2/3 Directing PG-PROTACs. [PDF]

ACS Med Chem Lett, 2022
Alcock LJ, Chang Y, Jarusiewicz JA, Actis M, Nithianantham S, Mayasundari A, Min J, Maxwell D, Hunt J, Smart B, Yang JJ, Nishiguchi G, Fischer M, Mullighan CG, Rankovic Z.   +14 more
europepmc   +1 more source