Results 161 to 170 of about 24,933,173 (248)
Cross‐Platform Comparison of Chemoproteomics Workflows: Orbitrap‐TMT Versus timsTOF‐diaPASEF
PROTEOMICS, EarlyView.ABSTRACT Chemoproteomics aims to achieve precise and comprehensive quantification of protein–small molecule interactions, yet methodological comparisons across quantitative proteomics workflows remain scarce. Here, we systematically benchmark tandem mass tag data‐dependent acquisition (TMT‐DDA) on Orbitrap Exploris/Eclipse instruments against label ...
Ursula M. Glocker +7 more
wiley +1 more source
Use of Janus Kinase Inhibitor Upadacitinib in Microscopic Colitis
Microscopic colitis is an inflammatory disease diagnosed via histopathology, often presenting with chronic nonbloody diarrhea. A 64-year-old woman was initially diagnosed in 2016 and received multiple standard treatments, which were ineffective and ...
Mumm, Beatrice, Stein, Daniel J.
core +1 more source
PROTEOMICS, EarlyView.ABSTRACT Triple‐negative breast cancer (TNBC) represents the most aggressive subtype with limited therapeutic options and the poorest clinical outcomes. Using high‐resolution nUPLC‐QTOF‐MS/MS, we performed comprehensive proteomic profiling of TNBC cell lines representing disease progression stages: HCC‐1937 (stage IIB), HCC‐1599 (stage IIIA), and MDA ...
Claudia Sissely Chaviano‐Montes de Oca +7 more
wiley +1 more source
Supplemental Tables 1-2 and Supplemental Figures 1-2 for "Janus Kinase Inhibitors for Chronic Hand Eczema: A Systematic Review with Meta ...
Bai, Jia Qi Adam
core +1 more source
Precision Medical Sciences, EarlyView.Hyperglycemia‐driven cytokine activation initiates a sustained inflammatory cascade in diabetic kidney disease, promoting cellular injury and fibrogenic signaling. Integrating cytokine‐based biomarkers with risk stratification enables precision therapeutics that target inflammation and fibrosis, ultimately aiming to halt progression from early renal ...
Emmanuel Ifeanyi Obeagu
wiley +1 more source
Genomics and epigenomics of tissue repair: Implications for personalized medicine
Precision Medical Sciences, EarlyView.Genomic and epigenomic mechanisms govern tissue repair and regeneration through dynamic regulation of inflammation, cell fate, and extracellular matrix remodeling. The integration of multi‐omics, artificial intelligence, and precision regenerative therapies enables biomarker‐driven, personalized approaches to enhance healing and minimize fibrosis ...
Jharna Medhi +7 more
wiley +1 more source
, 2013 BackgroundThe Janus kinase (JAK) inhibitor, tofacitinib, has shown efficacy for the treatment of psoriasis in a phase IIb trial (A3921047; NCT00678210).ObjectivesTo report haematology data from the phase IIb trial, given the importance of JAK-dependent ...
Valdez, H +10 more
core
Janus kinase inhibitors (JAKi) are effective treatments for rheumatoid arthritis (RA), but growing evidence raises cardiovascular (CV) safety concerns. Given the elevated baseline CV risk in RA, appropriate risk stratification is essential.
Mario Cascone +8 more
core +1 more source
Sequencing of the Janus kinase 2 gene in cats with primary erythrocytosis [PDF]
, 2020 Emi N. Barker +4 more
openaire +2 more sources
CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 583-595, March 2025.ABSTRACT Prior pharmacokinetic (PK) analysis revealed that increased alpha‐1‐acid glycoprotein (AAG) levels are associated with decreased imatinib unbound fraction in coronavirus disease 2019 (COVID‐19) patients. This study aimed to investigate the PK of total and unbound concentrations of imatinib and the metabolite N‐desmethyl imatinib in ...
Medhat M. Said +10 more
wiley +1 more source