Results 171 to 180 of about 457,473 (371)

Association between Polymorphism in the Janus Kinase 2 (JAK2) Gene and Selected Performance Traits in Cattle and Sheep. [PDF]

Animals (Basel), 2023
Oster N, Szewczuk MA, Zych S, Stankiewicz T, Błaszczyk B, Wieczorek-Dąbrowska M.   +5 more
europepmc   +1 more source

Curcumin Suppresses Janus Kinase-STAT Inflammatory Signaling through Activation of Src Homology 2 Domain-Containing Tyrosine Phosphatase 2 in Brain Microglia [PDF]

, 2003
Hak Yong Kim, Eun Jung Park, Eun-hye Joe, Ilo Jou   +3 more
openalex   +1 more source

New Biologic and Small Molecule Therapies for Hidradenitis Suppurativa

JEADV Clinical Practice, EarlyView.
ABSTRACT Hidradenitis suppurativa (HS) is an inflammatory skin disease that has historically been underdiagnosed and, until recently, under‐researched. Furthermore, the pathophysiology of HS is complex, and not fully understood. Just three biologic medications—adalimumab (anti‐TNF‐α), secukinumab (anti‐IL17A) and bimekizumab (anti‐IL17A/F) are licensed
Emily Pender, Rosalind Hughes, Brian Kirby   +2 more
wiley   +1 more source

Age- and gender-based frequency and association of common myeloproliferative mutations in a South African cohort

African Journal of Laboratory Medicine
Background: Age, gender, and mutation type are key risk factors for myeloproliferative neoplasms (MPNs). Africa remains under-represented in global cancer statistics due to limited population-based genomic data.
Bathabile Mbele, Kapila Bhowan, Brendon Roets   +2 more
doaj   +1 more source

Experimental Pharmacological Management of Psoriasis

Journal of Experimental Pharmacology, 2021
Elena Campione,1 Terenzio Cosio,1 Monia Di Prete,2 Caterina Lanna,1 Annunziata Dattola,1 Luca Bianchi1 1Dermatologic Unit, Department of Systems Medicine, University of Rome Tor Vergata, Rome, 00133, Italy; 2Anatomic Pathology, University of Rome Tor ...
Campione E, Cosio T, Di Prete M, Lanna C, Dattola A, Bianchi L   +5 more
doaj  

Levetiracetam Reduces Early Inflammatory Response After Experimental Intracerebral Hemorrhage by Regulating the Janus Kinase 2 (JAK2)–Signal Transducer and Activator of Transcription 3 (STAT3) Signaling Pathway

, 2020
Jing Xiong, Han Zhou, Donglin Lu, Zixuan Wang, Heng-Jian Liu, Yuqi Sun, Jinxiang Xu, Yugong Feng, Ang Xing   +8 more
openalex   +1 more source

Supplementary Figure 2 from Pyridone 6, A Pan-Janus–Activated Kinase Inhibitor, Induces Growth Inhibition of Multiple Myeloma Cells [PDF]

, 2023
Laura Pedranzini, Tobias Dechow, Marjan Berishaj, Raymond L. Comenzo, Ping Zhou, Janeen Azare, William G. Bornmann, Jacqueline Bromberg   +7 more
openalex   +1 more source

Efficacy of Lebrikizumab in Patients With Severe Atopic Dermatitis Who Would be Eligible for Treatment Based on the South Korean Reimbursement Criteria

JEADV Clinical Practice, EarlyView.
ABSTRACT Background Lebrikizumab is approved to treat patients with moderate‐to‐severe atopic dermatitis (AD). Objectives This study evaluated the 16‐week efficacy outcomes of lebrikizumab in adults and adolescents with severe AD in ADvocate trials who would be eligible for treatment based on South Korean reimbursement‐like criteria. Methods This was a
Chong Hyun Won, Chun Wook Park, Jiyoung Ahn, Joo Yeon Ko, Sang Hyun Cho, Yang Won Lee, Joo Hee Lee, Khai Jing Ng, Min Young Hong, Jinglin Zhong, Martin Dossenbach, Sang Wook Son   +11 more
wiley   +1 more source

Role of Plasma Janus Kinase 2 in Assessment of Disease Activity in Ulcerative Colitis

SVU - International Journal of Medical Sciences
Background: Ulcerative colitis (UC) is a chronic autoimmune disease with increasing incidence worldwide. The pathophysiology of UC is multifactorial, including interplay between immune, gut microbiota, genetic vulnerability, and environment-related ...
Asmaa Mahdy Ghaith , Abeer Mahmoud Ibraheem , Ezzat Ali , Fatma Ibrahim Dwedar , Hussien Mahmoud Hussien   +4 more
doaj   +1 more source

Emodin has a cytotoxic activity against human multiple myeloma as a Janus-activated kinase 2 inhibitor [PDF]

, 2007
Akihiro Muto, Mayumi Hori, Yosuke Sasaki, Akari Saitoh, Iho Yasuda, Tadahito Maekawa, Tomoe Uchida, Keiko Asakura, Tomonori Nakazato, Toshio Kaneda, Masahiro Kizaki, Yasuo Ikeda, Tadashi Yoshida   +12 more
openalex   +1 more source