Results 171 to 180 of about 74,496 (193)

Downregulation of Chloride Channel ClC-2 by Janus Kinase 3

The Journal of Membrane Biology, 2014
Janus kinase-3 (JAK3) fosters proliferation and counteracts apoptosis of lymphocytes and tumor cells. The gain of function mutation (A572V)JAK3 has been discovered in acute megakaryoplastic leukemia. JAK3 is inactivated by replacement of lysine by alanine in the catalytic subunit ((K855A)JAK3).
Jamshed, Warsi, Bernat, Elvira, Zohreh, Hosseinzadeh, Ekaterina, Shumilina, Florian, Lang   +4 more
openaire   +2 more sources

Inhibition of Janus kinase 2 by cyclometalated rhodium complexes

MedChemComm, 2012
Cyclometalated rhodium complexes were synthesized and evaluated as JAK2 metal-based inhibitors. Complexes 1 and 2 inhibited JAK2 enzyme phosphorylation activity, reduced JAK2 autophosphorylation in cellulo and exhibited cytotoxicity towards HEL cancer cells. To our knowledge, these are the first two examples of metal-based inhibitors of JAK2.
Chung-Hang Leung, Hui Yang, Victor Pui-Yan Ma, Daniel Shiu-Hin Chan, Hai-Jing Zhong, Ying-Wei Li, Wang-Fun Fong, Dik-Lung Ma   +7 more
openaire   +1 more source

Expression, purification, and characterization of TYK-2 kinase domain, a member of the Janus kinase family

Biochemical and Biophysical Research Communications, 2010
The Janus kinase family consists of four members: JAK-1, -2, -3 and TYK-2. While JAK-2 and JAK-3 have been well characterized biochemically, there is little data on TYK-2. Recent work suggests that TYK-2 may play a critical role in the development of a number of inflammatory processes.
Brian, Korniski, Arthur J, Wittwer, Thomas L, Emmons, Troii, Hall, Stacy, Brown, Ann D, Wrightstone, Jeffrey L, Hirsch, Jennifer A, Gormley, Robin A, Weinberg, Joseph W, Leone, Jacqueline E, Day, Jill E, Chrencik, Cynthia D, Sommers, H David, Fischer, Alfredo G, Tomasselli   +14 more
openaire   +2 more sources

Identification of 4-(2-furanyl)pyrimidin-2-amines as Janus kinase 2 inhibitors

Bioorganic & Medicinal Chemistry, 2017
Janus kinases inhibitor is considered to have therapeutic potential for the treatment of oncology and immune-inflammatory diseases. Two series of 4-(2-benzofuranyl)pyrimidin-2-amine and 4-(4,5,6,7-tetrahydrofuro[3,2-c]pyridin-2-yl)pyrimidin-2-amine derivatives have been designed and synthesized.
Yazhou, Wang, Wei, Huang, Minhang, Xin, Pan, Chen, Li, Gui, Xinge, Zhao, Feng, Tang, Jia, Wang, Fei, Liu   +8 more
openaire   +2 more sources

Potential Use of Janus Kinase Inhibitors in the Treatment of Systemic Lupus Erythematosus

Journal of Inflammation Research, 2023
Rongxiu Huo, Xinxiang Huang, Jinying Lin   +2 more
exaly  

Structural basis of Janus kinase trans-activation

Cell Reports, 2023
Nathanael A Caveney, Robert A Saxton, Deepa Waghray   +2 more
exaly  

Janus Kinase Inhibitors and Risk of Venous Thromboembolism: A Systematic Review and Meta-analysis

Mayo Clinic Proceedings, 2021
Jawad Bilal, Irbaz bin Riaz, Syed Arsalan Ahmed Naqvi   +2 more
exaly  

Real-world safety and clinical response of Janus kinase inhibitor upadacitinib in the treatment of hidradenitis suppurativa: A retrospective cohort study

Journal of the American Academy of Dermatology, 2022
John W Frew
exaly  

<p>Emerging Role of Janus Kinase Inhibitors for the Treatment of Atopic Dermatitis</p>

ImmunoTargets and Therapy, 2020
Rhea Singh, Courtney E Heron, Rima I Ghamrawi   +2 more
exaly  

Oral spleen tyrosine kinase/Janus Kinase inhibitor gusacitinib for the treatment of chronic hand eczema: Results of a randomized phase 2 study

Journal of the American Academy of Dermatology, 2023
, Mark Lee
exaly